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Diabetic cardiomyopathy (DCM) is defined as a cardiac dysfunction derived from DM without the presence of coronary artery diseases and hypertension. Patients with either type 1 or type 2 DM are at high risk of developing DCM and even heart failure. Metabolic disorders of obesity and insulin resistance in type 2 diabetic environments result in dyslipidaemia and subsequent lipid-induced toxicity (lipotoxicity) in organs including the heart. Although various mechanisms have been proposed underlying DCM, it remains incompletely understood how lipotoxicity alters cardiac function and how DM induces clinical heart syndrome. With recent progress, we here summarize the latest discoveries on lipid-induced cardiac toxicity in diabetic hearts and discuss the underlying therapies and controversies in clinical DCM.<\/jats:p>","DOI":"10.1002\/ehf2.14224","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T21:59:05Z","timestamp":1668203945000},"page":"776-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Diabetic Cardiomyopathy: A Brief Summary on Lipid Toxicity"],"prefix":"10.1093","volume":"10","author":[{"given":"Jiahan","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"2026012114121034900_ehf214224-bib-0001","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/eurheartj\/ehz486","article-title":"2019 ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in 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