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Herein, we present the case of a 68-year-old Chinese man with nonobstructive HCM admitted to our hospital with dyspnoea [New York Heart Association (NYHA) functional Class IV]. Transthoracic echocardiography indicated severe MR in addition to asymmetric hypertrophy of the left ventricle. Despite administering maximal medical therapy for heart failure, the symptoms were not alleviated; because of the high risk of open surgery, TEER was performed for MR. After 4 months of follow-up, the patient showed a significant improvement in symptoms. Herein, we also discuss and review the pathophysiology and treatment strategies for HCM patients with heart failure.<\/jats:p>","DOI":"10.1002\/ehf2.14291","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T19:24:55Z","timestamp":1674242695000},"page":"1454-1460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Use of MitraClip for Nonobstructive Hypertrophic Cardiomyopathy with Mixed Severe Mitral Valve Regurgitation"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2819-8752","authenticated-orcid":false,"given":"Jie","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglan","family":"Shu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ultrasound in Cardiac Electrophysiology and Biomechanics of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ultrasound in Cardiac Electrophysiology and Biomechanics of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu 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