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We assessed incidence and predictors of the long-term CV and non-CV events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients presenting with acute HF, EF \u2265 45%, and N-terminal pro-brain natriuretic peptide &amp;gt; 300 ng\/L were enrolled in the Karolinska-Rennes study in 2007\u201311 and were reassessed after 4\u20138 weeks in a stable state. Long-term follow-up was conducted in 2018. The Fine\u2013Gray sub-distribution hazard regression was used to detect predictors of CV and non-CV deaths, investigated separately from baseline acute presentation (demographic data only) and from the 4\u20138 week outpatient visit (including echocardiographic data). Of 539 patients enrolled [median age 78 (interquartile range: 72\u201384) years; 52% female], 397 patients were available for the long-term follow-up. Over a median follow-up time from acute presentation of 5.4 (2.1\u20137.9) years, 269 (68%) patients died, 128 (47%) from CV and 120 (45%) from non-CV causes. Incidence rates per 1000 patient-years were 62 [95% confidence interval (CI) 52\u201374] for CV and 58 (95% CI 48\u201369) for non-CV death. Higher age and coronary artery disease (CAD) were independent predictors of CV death, and anaemia, stroke, kidney disease, and lower body mass index (BMI) and sodium concentrations of non-CV death. From the stable 4\u20138 week visit, anaemia, CAD, and tricuspid regurgitation (&amp;gt;3.1 m\/s) were independent predictors of CV death, and higher age of non-CV death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with acute decompensated HFpEF, over 5 years of follow-up, nearly two-thirds of patients died, half from CV and the other half from non-CV causes. CAD and tricuspid regurgitation were associated with CV death. Stroke, kidney disease, lower BMI, and lower sodium were associated with non-CV death. Anaemia and higher age were associated with both outcomes. [Correction added on 24 March 2023, after first online publication: In the first sentence of the Conclusions, \u2018two-thirds\u2019 has been inserted before \u2018of patients died...\u2019 in this version.]<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14302","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T05:50:34Z","timestamp":1678427434000},"page":"1835-1846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Long-Term Outcomes in Heart Failure with Preserved Ejection Fraction: Predictors of Cardiac and Non-Cardiac Mortality"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-149X","authenticated-orcid":false,"given":"Angiza","family":"Shahim","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Hourqueig","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie, Centre Hospitalier Universitaire de Rennes , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars H.","family":"Lund","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Heart, Vascular and Neuro Theme, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Savarese","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Heart, Vascular and Neuro Theme, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Oger","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie, Centre Hospitalier Universitaire de Rennes , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Venkateshvaran","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Heart, Vascular and Neuro Theme, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Benson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Daubert","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universitaire de Rennes 1 , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Linde","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Heart, Vascular and Neuro Theme, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Donal","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universitaire de Rennes 1 , Rennes ,","place":["France"]},{"name":"D\u00e9partement de Cardiologie and CIC-IT U 804, Centre Hospitalier Universitaire de Rennes , Rennes 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