{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:51:30Z","timestamp":1782532290218,"version":"3.54.5"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":985,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Panzhihua Science and Technology Bureau","award":["2020ZD-S-26"],"award-info":[{"award-number":["2020ZD-S-26"]}]},{"name":"Sichuan Medical Association Program","award":["2019TG17"],"award-info":[{"award-number":["2019TG17"]}]},{"name":"Sichuan Medical Association Program","award":["S20020"],"award-info":[{"award-number":["S20020"]}]},{"name":"Xinglin Scholar Program of Chengdu University of Traditional Chinese Medicine in 2020","award":["yyzx2020127"],"award-info":[{"award-number":["yyzx2020127"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Dilated cardiomyopathy (DCM) belongs to the common types of cardiomyopathies. The pathogenesis remains unclear despite the fact that various genes have been found associated with DCM. MMP2 is a zinc-dependent and calcium-containing secreted endoproteinases, which could cleave a broad spectrum of substrates including extracellular matrix components and cytokines. It has proved to play an important role in the cardiovascular diseases. This study aimed to investigate the potential role of MMP2 gene polymorphisms in DCM susceptibility and prognosis in a Chinese Han population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 600 idiopathic DCM patients and 700 healthy controls were enrolled. Patients with contact information were followed up for a median period of 28 months. Three tagged single nucleotide polymorphisms (rs243865, rs2285052, and rs2285053) in the promoter of MMP2 gene were genotyped. A series of function analysis were conducted to illuminate the underlying mechanism. The frequency of rs243865-C allele was increased in DCM patients when compared with healthy controls (P = 0.001). Genotypic frequencies of rs243865 were associated with the susceptibility of DCM in the codominant, dominant, and overdominant models (P &amp;lt; 0.05). Besides, rs243865-C allele presented a correlation with the poor prognosis of DCM patients in both dominant (HR = 2.0, 95% confidence interval [CI] = 1.14\u20133.57, P = 0.017) and additive (HR = 1.85, 95% CI = 1.09\u20133.13, P = 0.02) model. The statistical significance remained after adjustment for sex, age, hypertension, diabetes, hyperlipidaemia, and smoking status. There were significant differences in left ventricular end-diastolic diameter and left ventricular ejection fraction between rs243865-CC and CT genotypes. Functional analysis indicated that rs243865-C allele increased luciferase activity and the mRNA expression level of MMP2 by facilitating ZNF354C binding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggested that MMP2 gene polymorphisms were associated with DCM susceptibility and prognosis in the Chinese Han population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14333","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T06:14:16Z","timestamp":1677824056000},"page":"1793-1802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association Between MMP2 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Han Population"],"prefix":"10.1093","volume":"10","author":[{"given":"Shiyang","family":"Li","sequence":"first","affiliation":[{"name":"Division of Cardiology, Panzhihua Central Hospital , Panzhihua ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Panzhihua Central Hospital , Panzhihua ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihai","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Panzhihua Central Hospital , Panzhihua ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuang","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Panzhihua Central Hospital , Panzhihua ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Lan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Panzhihua Central Hospital , Panzhihua ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"2026012114100820000_ehf214333-bib-0001","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10741-021-10125-6","article-title":"Dilated cardiomyopathy. A new insight into the rare but common cause of heart failure","volume":"27","author":"Giri","year":"2022","journal-title":"Heart Fail Rev"},{"key":"2026012114100820000_ehf214333-bib-0002","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.657689","article-title":"Clinical significance of variants in the TTN gene in a large cohort of patients with sporadic dilated cardiomyopathy","volume":"8","author":"Xiao","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2026012114100820000_ehf214333-bib-0003","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.21037\/cdt-21-323","article-title":"Association between CDK8 gene polymorphisms and dilated cardiomyopathy in a Chinese Han population","volume":"11","author":"Zhang","year":"2021","journal-title":"Cardiovasc Diagn Ther"},{"key":"2026012114100820000_ehf214333-bib-0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/jcem-63-1-1","article-title":"Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration","volume":"63","author":"Brent","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"2026012114100820000_ehf214333-bib-0005","article-title":"Rhein inhibits the progression of Chemoresistant lung cancer cell lines via the Stat3\/snail\/MMP2\/MMP9 pathway","volume":"2022","author":"Liu","year":"2022","journal-title":"Biomed Res Int"},{"key":"2026012114100820000_ehf214333-bib-0006","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.21873\/invivo.12153","article-title":"Significant association of MMP2 promoter genotypes to asthma susceptibility in Taiwan","volume":"34","author":"Chen","year":"2020","journal-title":"In Vivo"},{"key":"2026012114100820000_ehf214333-bib-0007","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12967-022-03361-3","article-title":"Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer","volume":"20","author":"Li","year":"2022","journal-title":"J Transl Med"},{"key":"2026012114100820000_ehf214333-bib-0008","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1093\/cvr\/cvac076","article-title":"Arterial wall rejuvenation. The potential of targeting matrix metalloprotease 2 to treat vascular aging","volume":"118","author":"Ambardekar","year":"2022","journal-title":"Cardiovasc Res"},{"key":"2026012114100820000_ehf214333-bib-0009","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1172\/JCI22304","article-title":"Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice","volume":"115","author":"Matsumura","year":"2005","journal-title":"J Clin Invest"},{"key":"2026012114100820000_ehf214333-bib-0010","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/01.HYP.0000208840.30778.00","article-title":"Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload","volume":"47","author":"Matsusaka","year":"2006","journal-title":"Hypertension"},{"key":"2026012114100820000_ehf214333-bib-0011","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1161\/01.ATV.0000218496.60097.e0","article-title":"Effect of MMP-2 deficiency on atherosclerotic lesion formation in apoE-deficient mice","volume":"26","author":"Kuzuya","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026012114100820000_ehf214333-bib-0012","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/CS20090226","article-title":"Matrix metalloproteinase-2 predicts mortality in patients with acute coronary syndrome","volume":"118","author":"Dhillon","year":"2009","journal-title":"Clin Sci (Lond)"},{"key":"2026012114100820000_ehf214333-bib-0013","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/eci.12458","article-title":"Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients","volume":"45","author":"Bencsik","year":"2015","journal-title":"Eur J Clin Invest"},{"key":"2026012114100820000_ehf214333-bib-0014","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.4238\/2015.May.4.20","article-title":"Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer","volume":"14","author":"Zhang","year":"2015","journal-title":"Genet Mol Res"},{"key":"2026012114100820000_ehf214333-bib-0015","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/08820139.2016.1180303","article-title":"Functional promoter polymorphisms of MMP-2 C-735T and MMP-9 C-1562T and their synergism with MMP-7 A-181G in multiple sclerosis","volume":"45","author":"Rahimi","year":"2016","journal-title":"Immunol Invest"},{"key":"2026012114100820000_ehf214333-bib-0016","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.gene.2016.05.028","article-title":"Matrix metalloproteinase (MMP) -2, \u22127 and \u22129 promoter polymorphisms in colorectal cancer in ethnic Kashmiri population - a case-control study and a mini review","volume":"589","author":"Banday","year":"2016","journal-title":"Gene"},{"key":"2026012114100820000_ehf214333-bib-0017","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s40291-016-0225-0","article-title":"MMP-2 (\u22121306 C\/T) polymorphism affects serum matrix metalloproteinase (MMP)-2 levels and correlates with chronic obstructive pulmonary disease severity. A case-control study of MMP-1 and -2 in a Tunisian population","volume":"20","author":"Bchir","year":"2016","journal-title":"Mol Diagn Ther"},{"key":"2026012114100820000_ehf214333-bib-0018","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012302","article-title":"Matrix metalloproteinase-2 gene polymorphisms are associated with ischemic stroke in a Hainan population","volume":"97","author":"Niu","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"2026012114100820000_ehf214333-bib-0019","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s00059-007-3045-5","article-title":"The classification concept of the ESC working group on myocardial and pericardial diseases for dilated cardiomyopathy","volume":"32","author":"Kaski","year":"2007","journal-title":"Herz"},{"key":"2026012114100820000_ehf214333-bib-0020","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10557-020-06960-8","article-title":"A common missense variant in OMA1 associated with the prognosis of heart failure","volume":"34","author":"Hu","year":"2020","journal-title":"Cardiovasc Drugs Ther"},{"key":"2026012114100820000_ehf214333-bib-0021","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1161\/CIRCRESAHA.109.215616","article-title":"A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease","volume":"106","author":"Ding","year":"2010","journal-title":"Circ Res"},{"key":"2026012114100820000_ehf214333-bib-0022","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJMoa021737","article-title":"The epidemiology of childhood cardiomyopathy in Australia","volume":"348","author":"Nugent","year":"2003","journal-title":"N Engl J Med"},{"key":"2026012114100820000_ehf214333-bib-0023","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1161\/CIRCRESAHA.114.301673","article-title":"Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling. Cardiac metalloproteinase actions (CarMA) postulates","volume":"114","author":"Iyer","year":"2014","journal-title":"Circ Res"},{"key":"2026012114100820000_ehf214333-bib-0024","doi-asserted-by":"crossref","first-page":"134","DOI":"10.7150\/jca.51854","article-title":"Gastrin\/CCK-B receptor signaling promotes cell invasion and metastasis by upregulating MMP-2 and VEGF expression in gastric cancer","volume":"13","author":"Zhao","year":"2022","journal-title":"J Cancer"},{"key":"2026012114100820000_ehf214333-bib-0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2020.105797","article-title":"SPAG5 promotes osteosarcoma metastasis via activation of FOXM1\/MMP2 axis","volume":"126","author":"Li","year":"2020","journal-title":"Int J Biochem Cell Biol"},{"key":"2026012114100820000_ehf214333-bib-0026","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1124\/jpet.105.091140","article-title":"Hyperlipidemia attenuates the infarct size-limiting effect of ischemic preconditioning. Role of matrix metalloproteinase-2 inhibition","volume":"316","author":"Giricz","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"2026012114100820000_ehf214333-bib-0027","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jjcc.2012.01.009","article-title":"Immediate administration of atorvastatin decreased the serum MMP-2 level and improved the prognosis for acute heart failure","volume":"59","author":"Shirakabe","year":"2012","journal-title":"J Cardiol"},{"key":"2026012114100820000_ehf214333-bib-0028","first-page":"315","article-title":"Metalloproteinases-2 and -9 predict left ventricular remodeling after myocardial infarction","volume":"100","author":"Cogni","year":"2013","journal-title":"Arq Bras Cardiol"},{"key":"2026012114100820000_ehf214333-bib-0029","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1007\/s13277-015-4378-y","article-title":"The protective role of the -1306CT functional polymorphism in matrix metalloproteinase-2 gene is associated with cervical cancer. Implication of human papillomavirus infection","volume":"37","author":"Singh","year":"2016","journal-title":"Tumour Biol"},{"key":"2026012114100820000_ehf214333-bib-0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.pathophys.2017.05.001","article-title":"Association between matrix metaloproteinases 2-1306C\/T polymorphism and the risk of coronary artery disease in Iranian population","volume":"24","author":"Sattari","year":"2017","journal-title":"Pathophysiology"},{"key":"2026012114100820000_ehf214333-bib-0031","first-page":"597","article-title":"The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer","volume":"21","author":"Radunovic","year":"2016","journal-title":"J BUON"},{"key":"2026012114100820000_ehf214333-bib-0032","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/02688697.2018.1427213","article-title":"Association of functional MMP-2 gene variant with intracranial aneurysms. Case-control genetic association study and meta-analysis","volume":"32","author":"Alg","year":"2018","journal-title":"Br J Neurosurg"},{"key":"2026012114100820000_ehf214333-bib-0033","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cancergen.2017.03.006","article-title":"Single nucleotide polymorphisms in an Indian cohort and association of CNTN4, MMP2 and SNTB1 variants with oral cancer","volume":"214-215","author":"Yete","year":"2017","journal-title":"Cancer Genet"},{"key":"2026012114100820000_ehf214333-bib-0034","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/01.RES.0000178789.16929.cf","article-title":"Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice","volume":"97","author":"Kassiri","year":"2005","journal-title":"Circ Res"},{"key":"2026012114100820000_ehf214333-bib-0035","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00428-004-1177-z","article-title":"Extracellular matrix proteins and matrix metalloproteinases differ between various right and left ventricular sites in end-stage cardiomyopathies","volume":"446","author":"Herpel","year":"2005","journal-title":"Virchows Arch"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.14333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.14333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/10\/3\/1793\/65017897\/eschf_10_3_1793.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/10\/3\/1793\/65017897\/eschf_10_3_1793.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:11:18Z","timestamp":1769022678000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/10\/3\/1793\/8304677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3,3]]},"published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.14333","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,3,3]]},"assertion":[{"value":"2022-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}