{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:19:53Z","timestamp":1791908393700,"version":"4.3.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":916,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873132"],"award-info":[{"award-number":["81873132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860786"],"award-info":[{"award-number":["81860786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Open Project of Gansu Research Center of Traditional Chinese Medicine","award":["zyzx-2020-zx8"],"award-info":[{"award-number":["zyzx-2020-zx8"]}]},{"name":"Lanzhou Science and Technology Plan Project","award":["2022-3-27"],"award-info":[{"award-number":["2022-3-27"]}]},{"name":"2018 Chinese medicine research projects to prevent and treat major diseases","award":["GZKZD-2018-02"],"award-info":[{"award-number":["GZKZD-2018-02"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873132"],"award-info":[{"award-number":["81873132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860786"],"award-info":[{"award-number":["81860786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Early diagnosis of cancer treatment-related cardiac dysfunction (CTRCD) is important as cancer therapy increases the risk of cardiac dysfunction. High-sensitivity cardiac troponin T (hs-cTnT) is a highly specific marker of myocardial injury. However, its diagnostic value for CTRCD has not been systematically evaluated. This meta-analysis aimed to evaluate whether hs-cTnT could be used as an early diagnostic biomarker for CTRCD. We systematically surveyed PubMed, Embase, Cochrane Library, and Web of Science databases for studies of hs-cTnT for the diagnosis of CTRCD before 1 April 2022. Patients of all ages and all cancer types who underwent echocardiographic left ventricular ejection fraction assessment and blood hs-cTnT and received anticancer therapy (including chemotherapy, radiotherapy, targeted therapy, immune checkpoint inhibitors, and other treatments) were included in this study, resulting in a total of eight studies with 1294 patients. The occurrence of CTRCD was associated with elevated hs-cTnT [sensitivity: 0.78, 95% confidence interval (CI): 0.64\u20130.88; specificity: 0.75, 95% CI: 0.59\u20130.86; area under the curve (AUC): 0.83, 95% CI: 0.80\u20130.86]. We further performed subgroup analysis and found that the AUC of hs-cTnT elevation for the diagnosis of CTRCD increased from 0.83 to 0.90 (95% CI: 0.87\u20130.92) at 3\u20136 months, suggesting a higher early diagnostic value of hs-cTnT compared with echocardiography for CTRCD. In terms of clinical applicability, the Fagan plot showed pre-test and post-test probabilities of 51% and 9%, respectively, indicating that hs-cTnT testing can improve the accuracy of clinical diagnosis of CTRCD. However, it was not possible to determine the optimal cut-off value for early diagnosis of CTRCD with hs-cTnT. The Deeks funnel plot was largely symmetrical (P = 0.74); hence, publication bias was not observed. Hs-cTnT allowed early CTRCD diagnosis at 3\u20136 months. However, further high-quality research is needed to determine the optimal cut-off value for early CTRCD diagnosis with this biomarker.<\/jats:p>","DOI":"10.1002\/ehf2.14373","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:59:56Z","timestamp":1683853196000},"page":"2170-2182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Early Diagnostic Value of High-Sensitivity Cardiac Troponin T for Cancer Treatment-Related Cardiac Dysfunction: A Meta-Analysis"],"prefix":"10.1093","volume":"10","author":[{"given":"Xinfang","family":"Lv","sequence":"first","affiliation":[{"name":"Gansu University of Chinese Medicine , Lanzhou, 730000 ,","place":["China"]},{"name":"Key Laboratory of Prevention and Treatment for Chronic Diseases by Traditional Chinese Medicine, University Hospital of Gansu Traditional Chinese Medicine , Lanzhou ,","place":["China"]},{"name":"Affiliated Hospital of Gansu University of Chinese Medicine , Lanzhou ,","place":["China"]},{"name":"Research Center of Traditional Chinese Medicine , Lanzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChenLiang","family":"Pan","sequence":"additional","affiliation":[{"name":"The First Hospital of Lanzhou University , Lanzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Guo","sequence":"additional","affiliation":[{"name":"Gansu Provincial Academic Institute for Medical Research , Lanzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chang","sequence":"additional","affiliation":[{"name":"Gansu Provincial Hospital , Lanzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine , Lanzhou, 730000 ,","place":["China"]},{"name":"Key Laboratory of Prevention and Treatment for Chronic Diseases by Traditional Chinese Medicine, University Hospital of Gansu Traditional Chinese Medicine , Lanzhou ,","place":["China"]},{"name":"Affiliated Hospital of Gansu University of Chinese Medicine , Lanzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wu","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine , Lanzhou, 730000 ,","place":["China"]},{"name":"Key Laboratory of Prevention and Treatment for Chronic Diseases by Traditional Chinese Medicine, University Hospital of Gansu Traditional Chinese Medicine , Lanzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhi","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine , Lanzhou, 730000 ,","place":["China"]},{"name":"Key Laboratory of Prevention and Treatment for Chronic Diseases by Traditional Chinese Medicine, University Hospital of Gansu Traditional Chinese Medicine , Lanzhou ,","place":["China"]},{"name":"Affiliated Hospital of Gansu University of Chinese Medicine , Lanzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunzhen","family":"Ren","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine , Lanzhou, 730000 ,","place":["China"]},{"name":"Key Laboratory of Prevention and Treatment for Chronic Diseases by Traditional Chinese Medicine, University Hospital of Gansu Traditional Chinese Medicine , Lanzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilin","family":"Chen","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine , Lanzhou, 730000 ,","place":["China"]},{"name":"Key Laboratory of Prevention and Treatment for Chronic Diseases by Traditional Chinese Medicine, University Hospital of Gansu Traditional Chinese Medicine , Lanzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine , Lanzhou, 730000 ,","place":["China"]},{"name":"Key Laboratory of Prevention and Treatment for Chronic Diseases by Traditional Chinese Medicine, University Hospital of Gansu Traditional Chinese Medicine , Lanzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinke","family":"Zhao","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine , Lanzhou, 730000 ,","place":["China"]},{"name":"Key Laboratory of Prevention and Treatment for Chronic Diseases by Traditional Chinese Medicine, University Hospital of Gansu Traditional Chinese Medicine , Lanzhou ,","place":["China"]},{"name":"Affiliated Hospital of Gansu University of Chinese Medicine , Lanzhou 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