{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:16:15Z","timestamp":1790388975800,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":912,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Barts Charity Cardiovascular Programme","award":["MGU0284"],"award-info":[{"award-number":["MGU0284"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The DCM Support trial (NCT03572660) uses a percutaneous circulatory support device (Impella CP, Abiomed, Danvers, MA, USA) to improve the safety of an intracoronary cell infusion procedure in patients with dilated cardiomyopathy (DCM) and a severely reduced left ventricular ejection fraction (LVEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>DCM Support is a single-site, single-arm Phase II trial enrolling 20 symptomatic DCM patients with an LVEF \u2264 35% despite optimal medical and device therapy. After 5 days of granulocyte colony-stimulating factor therapy and a subsequent bone marrow aspiration, patients undergo an intracoronary infusion of autologous bone-marrow-derived mononuclear cells. The Impella CP device is used to provide haemodynamic support during the infusion procedure. The trial's primary endpoint is change in LVEF from baseline at 3 months. Secondary efficacy endpoints are change in LVEF from baseline at 12 months, and change in exercise capacity, New York Heart Association class, quality of life, and N-terminal pro-B-type natriuretic peptide levels from baseline at 3 and 12 months. Safety endpoints include procedural safety and major adverse cardiac events at 3 and 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first trial to assess the safety and efficacy of cytokine and autologous intracoronary cell therapy with a procedural circulatory support device for patients with severe left ventricular impairment. This novel combination may allow us to target a patient population most at need of this therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14393","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T02:28:03Z","timestamp":1684204083000},"page":"2664-2671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["DCM Support: Cell Therapy and Circulatory Support for Dilated Cardiomyopathy Patients with Severe Ventricular Impairment"],"prefix":"10.1093","volume":"10","author":[{"given":"Alice","family":"Reid","sequence":"first","affiliation":[{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London , London ,","place":["UK"]},{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust , London ,","place":["UK"]},{"name":"NIHR Barts Biomedical Research Centre, Queen Mary University of London , Charterhouse Square, London, London, EC1M 6BQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsin","family":"Hussain","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessry","family":"Veerapen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini","family":"Ramaseshan","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London , London ,","place":["UK"]},{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Bowles","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London , London ,","place":["UK"]},{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust , London ,","place":["UK"]},{"name":"NIHR Barts Biomedical Research Centre, Queen Mary University of London , Charterhouse Square, London, London, EC1M 6BQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London , London ,","place":["UK"]},{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Mathur","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London , London ,","place":["UK"]},{"name":"Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust , London ,","place":["UK"]},{"name":"NIHR Barts Biomedical Research Centre, Queen Mary University of London , Charterhouse Square, London, London, EC1M 6BQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"2026012114093514200_ehf214393-bib-0001","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1016\/j.jacc.2016.03.590","article-title":"The diagnosis and evaluation of dilated cardiomyopathy","volume":"67","author":"Japp","year":"2016","journal-title":"J Am Coll Cardiol."},{"key":"2026012114093514200_ehf214393-bib-0002","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1053\/euhj.2002.3255","article-title":"Impact of heart failure and left ventricular systolic dysfunction on quality of life: a cross-sectional study comparing common chronic cardiac and medical disorders and a representative adult population","volume":"23","author":"Hobbs","year":"2002","journal-title":"Eur Heart J."},{"key":"2026012114093514200_ehf214393-bib-0003","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1093\/eurheartj\/ehv390","article-title":"Randomized trial of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with non-ischaemic dilated cardiomyopathy: the REGENERATEDCM clinical trial","volume":"36","author":"Hamshere","year":"2015","journal-title":"Eur Heart J."},{"key":"2026012114093514200_ehf214393-bib-0004","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cardfail.2010.11.007","article-title":"Effects of intracoronary stem cell transplantation in patients with dilated cardiomyopathy","volume":"17","author":"Vrtovec","year":"2011","journal-title":"J Card Fail."},{"key":"2026012114093514200_ehf214393-bib-0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/CIRCRESAHA.112.276519","article-title":"Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up","volume":"112","author":"Vrtovec","year":"2013","journal-title":"Circ Res."},{"key":"2026012114093514200_ehf214393-bib-0006","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cardfail.2014.11.005","article-title":"Intracoronary transplantation of CD34+ cells is associated with improved myocardial perfusion in patients with nonischemic dilated cardiomyopathy","volume":"21","author":"Lezaic","year":"2015","journal-title":"J Card Fail."},{"key":"2026012114093514200_ehf214393-bib-0007","doi-asserted-by":"crossref","first-page":"632","DOI":"10.5966\/sctm.2015-0172","article-title":"Efficacy of CD34+ stem cell therapy in nonischemic dilated cardiomyopathy is absent in patients with diabetes but preserved in patients with insulin resistance","volume":"5","author":"Vrtovec","year":"2016","journal-title":"Stem Cells Transl Med."},{"key":"2026012114093514200_ehf214393-bib-0008","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1161\/CIRCRESAHA.117.312170","article-title":"Effects of repetitive transendocardial CD34+ cell transplantation in patients with nonischemic dilated cardiomyopathy","volume":"123","author":"Vrtovec","year":"2018","journal-title":"Circ Res."},{"key":"2026012114093514200_ehf214393-bib-0009","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ijcard.2008.06.002","article-title":"Granulocyte-colony stimulating factor or granulocyte-colony stimulating factor associated to stem cell intracoronary infusion effects in non ischemic refractory heart failure","volume":"138","author":"Bocchi","year":"2010","journal-title":"Int J Cardiol."},{"key":"2026012114093514200_ehf214393-bib-0010","volume-title":"The PCR-EAPCI Textbook","author":"Mathur","year":"2021"},{"key":"2026012114093514200_ehf214393-bib-0011","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1016\/j.jacc.2006.07.057","article-title":"Percutaneous intracoronary cellular cardiomyoplasty for nonischemic cardiomyopathy: clinical and histopathological results: the first-in-man ABCD (Autologous Bone Marrow Cells in Dilated Cardiomyopathy) trial","volume":"48","author":"Seth","year":"2006","journal-title":"J Am Coll Cardiol."},{"key":"2026012114093514200_ehf214393-bib-0012","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1161\/CIRCHEARTFAILURE.109.855023","article-title":"A pilot trial to assess potential effects of selective intracoronary bone marrow-derived progenitor cell infusion in patients with nonischemic dilated cardiomyopathy: final 1-year results of the transplantation of progenitor cells and functional regeneration enhancement pilot trial in patients with nonischemic dilated cardiomyopathy","volume":"2","author":"Fischer-Rasokat","year":"2009","journal-title":"Circ Heart Fail"},{"key":"2026012114093514200_ehf214393-bib-0013","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1536\/ihj.16-328","article-title":"A randomized comparative study on the efficacy of intracoronary infusion of autologous bone marrow mononuclear cells and mesenchymal stem cells in patients with dilated cardiomyopathy","volume":"58","author":"Xiao","year":"2017","journal-title":"Int Heart J."},{"key":"2026012114093514200_ehf214393-bib-0014","article-title":"Stem cell therapy for chronic ischaemic heart disease and congestive heart failure","volume":"2016","author":"Fisher","year":"2016","journal-title":"Cochrane Database Syst Rev."},{"key":"2026012114093514200_ehf214393-bib-0015","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11113205","article-title":"Meta-analysis of percutaneous endomyocardial cell therapy in patients with ischemic heart failure by combination of individual patient data (IPD) of ACCRUE and publication-based aggregate data","volume":"11","author":"Gy\u00f6ngy\u00f6si","year":"2022","journal-title":"J Clin Med."},{"key":"2026012114093514200_ehf214393-bib-0016","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/j.jacc.2012.01.046","article-title":"Head-to-head comparison of left ventricular function assessment with 64-row computed tomography, biplane left cineventriculography, and both 2- and 3-dimensional transthoracic echocardiography: comparison with magnetic resonance imaging as the reference standard","volume":"59","author":"Greupner","year":"2012","journal-title":"J Am Coll Cardiol."},{"key":"2026012114093514200_ehf214393-bib-0017","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.jacc.2021.03.310","article-title":"Impact of percutaneous coronary intervention on outcomes in patients with heart failure","volume":"77","author":"Parikh","year":"2021","journal-title":"J Am Coll Cardiol."},{"key":"2026012114093514200_ehf214393-bib-0018","first-page":"532","article-title":"Effects of left ventricular unloading by Impella recover LP2.5 on coronary hemodynamics","volume":"70","author":"Remmelink","year":"2007","journal-title":"Catheter Cardiovasc Interv."},{"key":"2026012114093514200_ehf214393-bib-0019","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1080\/17434440.2017.1374849","article-title":"Utilization of the Impella for hemodynamic support during percutaneous intervention and cardiogenic shock: an insight","volume":"14","author":"Nalluri","year":"2017","journal-title":"Expert Rev Med Dev."},{"key":"2026012114093514200_ehf214393-bib-0020","doi-asserted-by":"crossref","first-page":"623.e1","DOI":"10.1016\/j.repc.2017.05.013","article-title":"The role of Impella in high-risk percutaneous coronary intervention","volume":"37","author":"Moura-Ferreira","year":"2018","journal-title":"Rev Port Cardiol."},{"key":"2026012114093514200_ehf214393-bib-0021","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ijcard.2015.07.065","article-title":"Impella ventricular support in clinical practice: collaborative viewpoint from a European expert user group","volume":"201","author":"Burzotta","year":"2015","journal-title":"Int J Cardiol."},{"key":"2026012114093514200_ehf214393-bib-0022","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1161\/CIRCULATIONAHA.112.098194","article-title":"A prospective, randomized clinical trial of hemodynamic support with Impella 2.5 versus intra-aortic balloon pump in patients undergoing high-risk percutaneous coronary intervention","volume":"126","author":"O'Neill","year":"2012","journal-title":"Circulation."},{"key":"2026012114093514200_ehf214393-bib-0023","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1055\/s-2003-45422","article-title":"Initial experiences with the Impella device in patients with cardiogenic shock","volume":"51","author":"Meyns","year":"2003","journal-title":"Thorac Cardiovasc Surg."},{"key":"2026012114093514200_ehf214393-bib-0024","first-page":"e751","article-title":"Late-breaking science abstracts from the American Heart Association's scientific sessions 2018 and late-breaking abstracts in resuscitation science from the Resuscitation Science Symposium 2018","volume":"138","author":"Pagani","year":"2018","journal-title":"Circulation."},{"key":"2026012114093514200_ehf214393-bib-0025","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.ijcard.2011.07.062","article-title":"Stem cells transplantation combined with long-term mechanical circulatory support enhances myocardial viability in end-stage ischemic cardiomyopathy","volume":"155","author":"Anastasiadis","year":"2012","journal-title":"Int J Cardiol."},{"key":"2026012114093514200_ehf214393-bib-0026","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.healun.2014.11.014","article-title":"Evidence for neoangiogenesis in the ischemic human heart after mechanical support and autologous bone marrow stem cell implantation","volume":"34","author":"Anastasiadis","year":"2015","journal-title":"J Hear Lung Transplant."},{"key":"2026012114093514200_ehf214393-bib-0027","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006462","article-title":"Left ventricular unloading using an Impella CP improves coronary flow and infarct zone perfusion in ischemic heart failure","volume":"7","author":"Watanabe","year":"2018","journal-title":"J Am Heart Assoc."},{"key":"2026012114093514200_ehf214393-bib-0028","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2217\/rme-2018-0121","article-title":"Circulatory support and stem cell therapy in the management of advanced heart failure: a concise review of available evidence","volume":"14","author":"Hussain","year":"2019","journal-title":"Regen Med."},{"key":"2026012114093514200_ehf214393-bib-0029","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1161\/CIRCULATIONAHA.113.007412","article-title":"Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices","volume":"129","author":"Ascheim","year":"2014","journal-title":"Circulation."},{"key":"2026012114093514200_ehf214393-bib-0030","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.jacc.2015.01.042","article-title":"Mechanisms of bone marrow\u2212derived cell therapy in ischemic cardiomyopathy with left ventricular assist device bridge to transplant","volume":"65","author":"Stempien-Otero","year":"2015","journal-title":"J Am Coll Cardiol."},{"key":"2026012114093514200_ehf214393-bib-0031","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1001\/jama.2019.2341","article-title":"Intramyocardial injection of mesenchymal precursor cells and successful temporary weaning from left ventricular assist device support in patients with advanced heart failure","volume":"321","author":"Yau","year":"2019","journal-title":"JAMA."},{"key":"2026012114093514200_ehf214393-bib-0032","article-title":"Intravenous administration of umbilical cord lining stem cells in left ventricular assist device recipient: rationale and design of the uSTOP LVAD BLEED pilot study","volume":"16","author":"Ahmed","year":"2022","journal-title":"Am Hear J Plus Cardiol Res Pract."}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/10\/4\/2664\/64704866\/eschf_10_4_2664.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/10\/4\/2664\/64704866\/eschf_10_4_2664.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:10:21Z","timestamp":1769022621000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/10\/4\/2664\/8285345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,5,15]]},"published-print":{"date-parts":[[2023,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.14393","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8]]},"published":{"date-parts":[[2023,5,15]]},"assertion":[{"value":"2022-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}