{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:09:32Z","timestamp":1787314172146,"version":"build-2736575974"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":582,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to analyse the characteristics and in-hospital outcomes of patients hospitalized for heart failure (HF) with co-morbid systemic sclerosis (SSc) and compare them to those without SSc, using data from the National Inpatient Sample from years 2016 to 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>International Classification of Diseases, Tenth Revision diagnosis codes were used to identify hospitalized patients with a primary diagnosis of HF and secondary diagnoses of SSc from the National Inpatient Sample database from 2016 to 2019. Patients were divided into two groups: those with and without a secondary diagnosis of SSc. Baseline characteristics including demographics and co-morbidities, outcomes of mortality, length of stay (LOS), and costs were compared between the two groups. Multivariable logistic regression analysis was performed to adjust for confounders and assess the impact of SSc on in-hospital mortality, cost, and LOS. A total of 4 709 724 hospitalizations for HF were identified, with 8150 (0.17%) having a secondary diagnosis of SSc. These patients were predominantly female (82.3% vs. 47.8%; P = 0.01), younger (mean age of 67.4 vs. 71.4; P &amp;lt; 0.01), and had significantly lower rates of traditional cardiovascular risk factors such as coronary artery disease (35.8% vs. 50.6%; P &amp;lt; 0.01), hyperlipidaemia (39.1% vs. 52.9%; P &amp;lt; 0.01), diabetes (22.5% vs. 49.1%; P &amp;lt; 0.01), obesity (13.2% vs. 25.0%; P &amp;lt; 0.01), and hypertension (20.2% vs. 23.8%; P &amp;lt; 0.01). Higher rates of co-morbid pulmonary disease in the form of interstitial lung disease (23.1% vs. 2.0%; P &amp;lt; 0.01) and pulmonary hypertension (36.6% vs. 12.7%; P &amp;lt; 0.01) were noted in the SSc cohort. Unadjusted in-hospital mortality was significantly higher in the HF with SSc group [5.1% vs. 2.6%; odds ratio: 1.99; 95% confidence interval (CI): 1.60\u20132.48; P &amp;lt; 0.001]. Unadjusted mortality was also higher among female (86.7% vs. 47.0%; P &amp;lt; 0.01), Black (15.7% vs. 13.0%; P &amp;lt; 0.01), and Hispanic (13.3% vs. 6.9%; P &amp;lt; 0.01) patients in the SSc cohort. After adjusting for potential confounders, SSc remained independently associated with higher in-hospital mortality (adjusted odds ratio: 1.81; 95% CI: 1.44\u20132.28; P &amp;lt; 0.001). Patients with HF and SSc also had longer LOS (6.4 vs. 5.4; adjusted mean difference [AMD]: 0.37, 95% CI: 0.05\u20130.68; P = 0.02) and higher hospitalization costs ($67 363 vs. $57 128; AMD: 198.9; 95% CI: \u22124780 to 5178; P = 0.93).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients hospitalized for HF, those with SSc were noted to have higher odds of in-hospital mortality than those without SSc. Patients with HF and SSc were more likely to be younger, female, and have higher rates of co-morbid interstitial lung disease and pulmonary hypertension at baseline with fewer traditional cardiovascular risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14457","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:38:41Z","timestamp":1710290321000},"page":"1900-1910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Systemic Sclerosis is Associated with Increased In-Patient Mortality in Patients Hospitalized for Heart Failure"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-3688","authenticated-orcid":false,"given":"Akil A.","family":"Sherif","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Diseases, St Vincent Hospital , Worcester, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinit J.","family":"Gilvaz","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University , Providence, RI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonu","family":"Abraham","sequence":"additional","affiliation":[{"name":"Divison of Cardiovascular diseases, Lahey Hospital & Medical Center , Burlington, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu Mariam","family":"Saji","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent Hospital , Worcester, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pittsburgh Medical Center , McKeesport, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameesh","family":"Isath","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Westchester Medical Center and New York Medical College , Valhalla, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiswarya","family":"Rajendran","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, University of Massachusetts , Amherst, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Contreras","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Advanced Heart Failure and Transplant, Mount Sinai Morningside and West , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg M.","family":"Lanier","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Westchester Medical Center and New York Medical College , Valhalla, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Reginato","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University , Providence, RI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"2026012113135982100_ehf214457-bib-0001","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet Lond Engl"},{"key":"2026012113135982100_ehf214457-bib-0002","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1136\/ard.2009.114264","article-title":"Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) 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