{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:37:35Z","timestamp":1776955055453,"version":"3.51.4"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":861,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The case of a 49-year-old man with acute onset of heart failure is presented. The initial work-up showed a dilated cardiomyopathy with severely reduced left ventricular ejection fraction. In the differential diagnostic process, hypertensive, ischaemic, and valvular aetiologies were discarded. Subsequently, a cardiac magnetic resonance revealed global hypokinesis and inferior and anterior subepicardial fibrosis. Once differential diagnoses of subepicardial fibrosis (myocarditis, sarcoidosis, and Chagas disease) were discarded, a genetic panel was performed, resulting in a heterozygous mutation of desmoplakin (DSP) gene c.6697_6698del. A left-dominant DSP arrhythmogenic cardiomyopathy mutation was diagnosed. Structural myocardial abnormalities and ventricular arrhythmias characterize arrhythmogenic cardiomyopathy. Up to 50% of cases are associated with mutations in DSP genes (JUP, DSP, and PKP2). DSP is the fundamental component of the desmosome structure and provides structural support through intercellular adhesion. Therefore, when frequent differential diagnoses are discarded, genetic studies for dilated cardiomyopathy and DSP mutation should be considered.<\/jats:p>","DOI":"10.1002\/ehf2.14504","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T04:29:46Z","timestamp":1693024186000},"page":"3190-3194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Left-Dominant Arrhythmogenic Cardiomyopathy Due to Desmoplakin Mutation: A Case Report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9509-8220","authenticated-orcid":false,"given":"Gustavo A.","family":"Lemus Barrios","sequence":"first","affiliation":[{"name":"Cardiology Unit, Hospital Universitario San Ignacio , Bogot\u00e1 ,","place":["Colombia"]},{"name":"Faculty of Medicine, Pontificia Universidad Javeriana , Bogot\u00e1 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8865-0929","authenticated-orcid":false,"given":"Jose P.","family":"Lopez-Lopez","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Hospital Universitario San Ignacio , Bogot\u00e1 ,","place":["Colombia"]},{"name":"Faculty of Medicine, Pontificia Universidad Javeriana , Bogot\u00e1 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephany","family":"Barbosa-Balaguera","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Hospital Universitario San Ignacio , Bogot\u00e1 ,","place":["Colombia"]},{"name":"Faculty of Medicine, Pontificia Universidad Javeriana , Bogot\u00e1 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro Mari\u00f1o","family":"Correa","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Hospital Universitario San Ignacio , Bogot\u00e1 ,","place":["Colombia"]},{"name":"Faculty of Medicine, Pontificia Universidad Javeriana , Bogot\u00e1 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,26]]},"reference":[{"key":"2026012114082396500_ehf214504-bib-0001","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1136\/heartjnl-2020-316944","article-title":"Arrhythmogenic left ventricular cardiomyopathy","volume":"108","author":"Corrado","year":"2022","journal-title":"Heart"},{"key":"2026012114082396500_ehf214504-bib-0002","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1161\/CIRCULATIONAHA.119.044934","article-title":"Desmoplakin cardiomyopathy, a fibrotic and inflammatory form of cardiomyopathy distinct from typical dilated or arrhythmogenic right ventricular cardiomyopathy","volume":"141","author":"Smith","year":"2020","journal-title":"Circulation"},{"key":"2026012114082396500_ehf214504-bib-0003","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s11897-021-00532-z","article-title":"Insights into genetics and pathophysiology of arrhythmogenic cardiomyopathy","volume":"18","author":"Gerull","year":"2021","journal-title":"Curr Heart Fail Rep"},{"key":"2026012114082396500_ehf214504-bib-0004","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1016\/j.jcmg.2020.07.028","article-title":"Inflammatory episodes of desmoplakin cardiomyopathy masquerading as myocarditis: unique features on cardiac magnetic resonance imaging","volume":"14","author":"Alley","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026012114082396500_ehf214504-bib-0005","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1002\/ejhf.1534","article-title":"Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert 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