{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:13:43Z","timestamp":1769843623233,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":700,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370290"],"award-info":[{"award-number":["82370290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200807"],"award-info":[{"award-number":["82200807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Sci-Tech Innovation Platform of Zhongnan Hospital of Wuhan University","award":["ptxm2021009"],"award-info":[{"award-number":["ptxm2021009"]}]},{"name":"Medical Sci-Tech Innovation Platform of Zhongnan Hospital of Wuhan University","award":["ptxm2022002"],"award-info":[{"award-number":["ptxm2022002"]}]},{"name":"Outstanding Young and Middle-aged Talents Training Program of Zhongnan Hospital of Wuhan University","award":["ZNYQ2022007"],"award-info":[{"award-number":["ZNYQ2022007"]}]},{"name":"Hubei Provincial Medical Young Top Talents Training Program"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370290"],"award-info":[{"award-number":["82370290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200807"],"award-info":[{"award-number":["82200807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Studies have confirmed that viral myocarditis (VMC) is one of the risk factors for dilated cardiomyopathy (DCM). The molecular mechanisms underlying the progression from VMC to DCM remain unclear and require further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The mRNA microarray datasets GSE57338 (DCM) and GSE1145 (VMC) were obtained from the Gene Expression Omnibus database. The candidate key genes were further screened using weighted correlation network analysis (WGCNA), protein\u2013protein interaction and external dataset validation, and the correlation between the candidate key genes and immune cells and the signalling pathways of the candidate key genes were observed by enrichment analysis and immune infiltration analysis. The expression of key genes was validated in the external dataset GSE35182. The crosstalk genes between DCM and VMC were mainly enriched in \u2018transcriptional misregulation in cancer\u2019, \u2018FoxO signalling pathway\u2019, \u2018AGE-RAGE signalling pathway in diabetic complications\u2019, \u2018thyroid hormone signalling pathway\u2019, \u2018AMPK signalling pathway\u2019, and other signalling pathways. The immune infiltration analysis indicated that VMC was mainly associated with resting dendritic cells and M0 macrophages, while DCM was mainly associated with monocytes, M0 macrophages, CD8+ T cells, resting CD4 memory T cells, naive CD4+ T cells, and resting mast cells. In DCM-related dataset GSE57338 and VMC-related dataset GSE1145, a total of 18 candidate key genes were differentially expressed. BLC6, FOXO1, and UBE2M were identified as the key genes that lead to the progression from VMC to DCM by GSE35182.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Three key genes (BLC6, FOXO1, and UBE2M) were identified and provided new insights into the diagnosis and treatment of VMC with DCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14585","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T19:34:47Z","timestamp":1700076887000},"page":"282-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of the Communal Pathogenesis and Immune Landscape Between Viral Myocarditis and Dilated Cardiomyopathy"],"prefix":"10.1093","volume":"11","author":[{"given":"Zhe","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhongnan Hospital of Wuhan University , No. 169 Donghu Road, Wuchang District, Wuhan, 430071 ,","place":["China"]},{"name":"Institute of Myocardial Injury and Repair, Wuhan University , Wuhan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongnan Hospital of Wuhan University , No. 169 Donghu Road, Wuchang District, Wuhan, 430071 ,","place":["China"]},{"name":"Institute of Myocardial Injury and Repair, Wuhan University , Wuhan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahe","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongnan Hospital of Wuhan University , No. 169 Donghu Road, Wuchang District, Wuhan, 430071 ,","place":["China"]},{"name":"Institute of Myocardial Injury and Repair, Wuhan University , Wuhan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongnan Hospital of Wuhan University , No. 169 Donghu Road, Wuchang District, Wuhan, 430071 ,","place":["China"]},{"name":"Institute of Myocardial Injury and Repair, Wuhan University , Wuhan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhongnan Hospital of Wuhan University , No. 169 Donghu Road, Wuchang District, Wuhan, 430071 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5441-6648","authenticated-orcid":false,"given":"Xiaorong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongnan Hospital of Wuhan University , No. 169 Donghu Road, Wuchang District, Wuhan, 430071 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