{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:15:06Z","timestamp":1790612106412,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":672,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC-82072159"],"award-info":[{"award-number":["NSFC-82072159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Province Financial Support Clinical Key Specialty Program","award":["2020-155"],"award-info":[{"award-number":["2020-155"]}]},{"name":"Clinical Capacity Enhancement Project of Jiangsu Province Hospital","award":["JSPH-MC-2022-28"],"award-info":[{"award-number":["JSPH-MC-2022-28"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC\u201082072159"],"award-info":[{"award-number":["NSFC\u201082072159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an important technique for the treatment of refractory cardiogenic shock and cardiac arrest; however, the early management of ventricular fibrillation\/ventricular tachycardia (VF\/VT), within 72 h of VA-ECMO, and its effects on patient prognosis remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively analysed patients at the First Affiliated Hospital of Nanjing Medical University who underwent VA-ECMO between January 2017 and March 2022. The patients were divided into two groups, VF\/VT and nVF\/VT, based on whether or not VF\/VT occurred within 72 h after the initiation of VA-ECMO. We utilized logistic regression analysis to evaluate the independent risk factors for VF\/VT in patients undergoing VA-ECMO and to ascertain whether the onset of VF\/VT affected 28 day survival rate, length of intensive care unit stay, and\/or other clinical prognostic factors. Subgroup analysis was performed for the VF\/VT group to determine whether defibrillation affected prognosis. In the present study, 126 patients were included, 65.87% of whom were males (83\/126), with a mean age of 46.89 \u00b1 16.23, a 28 day survival rate of 57.14% (72\/126), an incidence rate of VF\/VT within 72 h of VA-ECMO initiation of 27.78% (35\/126), and 80% of whom (28\/35) received extracorporeal cardiopulmonary resuscitation. The incidence of VF\/VT resulting from cardiac arrest at an early stage was significantly higher than that of refractory cardiogenic shock (80% vs. 20%; P = 0.022). The restricted cubic spline model revealed a U-shaped relationship between VF\/VT incidence and initial heart rate (iHR), and multivariate logistic regression analysis showed that an iHR &amp;gt; 120 b.p.m. [odds ratio (OR) 6.117; 95% confidence interval (CI) 1.672\u201322.376; P = 0.006] and hyperlactataemia (OR 1.125; 95% CI 1.016\u20131.246; P = 0.023) within 1 h of VA-ECMO initiation were independent risk factors for the occurrence of VF\/VT. VF\/VT was not found to be associated with the 28 day survival of patients undergoing VA-ECMO support, nor did it affect other secondary endpoints. Defibrillation did not alter the overall prognosis in patients with VF\/VT during VA-ECMO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An iHR &amp;gt; 120 b.p.m. and hyperlactataemia were independent risk factors for the occurrence of VF\/VT within 72 h of VA-ECMO initiation. The occurrence of VF\/VT does not affect, nor does defibrillation in these patients improve the overall patient prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ChiCTR1900026105.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14615","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:31:04Z","timestamp":1702445464000},"page":"524-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ventricular Fibrillation\/Ventricular Tachycardia Within 72 h of VA-ECMO: Incidence, Outcomes, Risk Factors, and Management"],"prefix":"10.1093","volume":"11","author":[{"given":"Hao","family":"Zhou","sequence":"first","affiliation":[{"name":"Emergency Department, Nanjing Medical University First Affiliated Hospital and Jiangsu Province Hospital , Guangzhou Street 300, Nanjing, Jiangsu Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Emergency Department, Nanjing Medical University First Affiliated Hospital and Jiangsu Province Hospital , Guangzhou Street 300, Nanjing, Jiangsu Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongman","family":"Zhang","sequence":"additional","affiliation":[{"name":"Emergency Department, Nanjing Medical University First Affiliated Hospital and Jiangsu Province Hospital , Guangzhou Street 300, Nanjing, Jiangsu Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Mei","sequence":"additional","affiliation":[{"name":"Emergency Department, Nanjing Medical University First Affiliated Hospital and Jiangsu Province Hospital , Guangzhou Street 300, Nanjing, Jiangsu Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinru","family":"Lv","sequence":"additional","affiliation":[{"name":"Emergency Department, Nanjing Medical University First Affiliated Hospital and Jiangsu Province Hospital , Guangzhou Street 300, Nanjing, Jiangsu Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Emergency Department, Nanjing Medical University First Affiliated Hospital and Jiangsu Province Hospital , Guangzhou Street 300, Nanjing, Jiangsu Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Emergency Department, Nanjing Medical University First Affiliated Hospital and Jiangsu Province Hospital , Guangzhou Street 300, Nanjing, Jiangsu Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Emergency Department, Nanjing Medical University First Affiliated Hospital and Jiangsu Province Hospital , Guangzhou Street 300, Nanjing, Jiangsu Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"2026012113075874500_ehf214615-bib-0001","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1093\/ehjacc\/zuab084","article-title":"Temporal trends in patient characteristics, presumed causes, and outcomes following cardiogenic shock between 2005 and 2017: A Danish registry-based cohort study","volume":"10","author":"Petersen","year":"2021","journal-title":"Eur Heart J Acute Cardiovasc 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