{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:18:37Z","timestamp":1790295517599,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":637,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Left ventricular aneurysm (LVA) is an important complication of acute myocardial infarction. The aim of this study was to investigate the possible predictive value of blood urea nitrogen-to-albumin ratio (BAR) for the LVA formation in acute ST-segment elevation myocardial infarction (STEMI) patients who underwent primary percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 1123 consecutive patients with STEMI were prospectively enrolled. The clinical and laboratory data were compared between LVA group and non-LVA group. Multivariable logistic regression analysis was performed to assess the independent risk factors of LVA formation. Predictive power of BAR and composite variable for LVA formation were assessed using receiver operating characteristic curve. LVA was detected in 162 patients (14.4%). The BAR was significantly higher in patients with LVA [0.16 (0.13\u20130.19) vs. 0.13 (0.10\u20130.17), P &amp;lt; 0.001]. Multivariable logistic regression analysis revealed that left ventricular ejection fraction (LVEF) [odds ratio (OR) = 0.865, P &amp;lt; 0.001], culprit vessel\u2013left anterior descending artery (LAD) (OR = 4.705, P &amp;lt; 0.001), and BAR (OR = 2.208, P = 0.018) were all independent predictors for LVA formation. The predictive value of BAR remained significant even after cross-validation by splitting population into training set (OR = 1.957, P = 0.034) and validation set (OR = 1.982, P = 0.039). The maximal length and width of LVA were significantly increased in patients with BAR \u2265 0.15 when compared with BAR &amp;lt; 0.15 (3.37 \u00b1 1.09 vs. 2.92 \u00b1 0.93, P = 0.01, for maximal length, and 2.20 \u00b1 0.55 vs. 1.85 \u00b1 0.63, P = 0.001, for maximal width). The discriminant power of BAR for LVA is 0.723, which is superior to both blood urea nitrogen (C statistic = 0.586, P &amp;lt; 0.001) and albumin (C statistic = 0.64, P &amp;lt; 0.001). The combination of BAR, LVEF, and culprit vessel\u2013LAD could significantly increase the predictive ability (C statistic = 0.874, P &amp;lt; 0.001, for vs. BAR). Subgroup analysis of age, sex, hypertension, diabetes, smoking, LVEF, serum albumin, multiple-vessel disease, and Gensini score had no effect on the association between BAR and risk of LVA formation (P &amp;lt; 0.05 for all subgroups).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A higher BAR was an independent predictor for LVA formation in STEMI patients with primary PCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14620","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T01:18:05Z","timestamp":1705540685000},"page":"974-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Urea Nitrogen-to-Albumin Ratio Predicts Ventricular Aneurysm Formation in ST-Segment Elevation Myocardial Infarction"],"prefix":"10.1093","volume":"11","author":[{"given":"Kai","family":"Zhang","sequence":"first","affiliation":[{"name":"Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University , Zhengzhou, Henan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Function Evaluation, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University , Zhengzhou, Henan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Wu","sequence":"additional","affiliation":[{"name":"Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University , Zhengzhou, Henan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University , Zhengzhou, Henan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University , Zhengzhou, Henan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"2026012113154935200_ehf214620-bib-0001","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1053\/ajem.2002.32634","article-title":"Electrocardiographic ST segment elevation: Left ventricular aneurysm","volume":"20","author":"Engel","year":"2002","journal-title":"Am J Emerg Med"},{"key":"2026012113154935200_ehf214620-bib-0002","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00380-012-0301-2","article-title":"Left ventricular apical aneurysm following primary percutaneous coronary intervention","volume":"28","author":"Mori","year":"2013","journal-title":"Heart Vessels"},{"key":"2026012113154935200_ehf214620-bib-0003","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/oxfordjournals.eurheartj.a060045","article-title":"Left ventricular aneurysm and prognosis in patients with first acute transmural anterior myocardial infarction and isolated left anterior descending artery disease","volume":"13","author":"Shen","year":"1992","journal-title":"Eur Heart J"},{"key":"2026012113154935200_ehf214620-bib-0004","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012109","article-title":"Impaired renal function and abnormal level of ferritin are independent risk factors of left ventricular aneurysm after acute myocardial infarction. 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