{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:05:23Z","timestamp":1792209923044,"version":"4.4.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":656,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Bergesen Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Our aim was to investigate haemodynamics at rest and during exercise in patients with transthyretin cardiomyopathy (ATTR-CM) in light of the 2022 European Society of Cardiology (ESC) and European Respiratory Society (ERS) guidelines on pulmonary hypertension (PH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We performed right heart catheterization (RHC) in 57 subjects with ATTR-CM. The proportion of patients with PH was 77% according to the 2022 guidelines versus 47% when applying the 2015 guidelines. Isolated post-capillary PH and combined pre- and post-capillary PH were most prevalent. Thirty-six patients underwent a supine bicycle cardiopulmonary exercise test during RHC. Exercise-induced PH was defined as an increase in mean pulmonary arterial pressure from rest to exercise per increase in cardiac output (\u0394mPAP\/\u0394CO) of &amp;gt; 3 mmHg\/L\/min. An increase in pulmonary arterial wedge pressure per change in cardiac output (\u0394PAWP\/\u0394CO) from rest to exercise &amp;gt;2 mmHg\/L\/min was considered suggestive of post-capillary exercise-induced PH. All but two patients who exercised during RHC developed exercise-induced PH. The median \u0394mPAP\/\u0394CO was 7.2 mmHg\/L\/min and \u0394PAWP\/\u0394CO was 5.1 mmHg\/L\/min. The median \u0394RAP\/\u0394CO was 3.6 mmHg\/L\/min and \u0394RAP\/\u0394PAWP was 0.6 mmHg\/L\/min.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most patients with ATTR-CM have isolated post-capillary or combined pre- and post-capillary PH at rest, and almost all patients develop exercise-induced PH with a large post-capillary component. There was a pronounced, but balanced increase in atrial pressures on exercise.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14621","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T01:34:38Z","timestamp":1703900078000},"page":"1263-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Invasive Haemodynamics at Rest and Exercise in Cardiac Amyloidosis"],"prefix":"10.1093","volume":"11","author":[{"given":"Margrethe Flesvig","family":"Holt","sequence":"first","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Rikshospitalet , Oslo ,","place":["Norway"]},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August","family":"Fl\u00f8","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo 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