{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:21:13Z","timestamp":1783401673424,"version":"3.54.6"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":589,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Predicting mortality in severe AL cardiac amyloidosis is challenging due to elevated biomarker levels and limited thresholds for stratifying severe cardiac damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This prospective, observational, cohort study included de novo, confirmed cardiac AL amyloidosis patients at the Henri Mondor National Reference Centre. The goal was to identify predictors of mortality to enhance prognostic stratification and improve informed decision-making regarding therapy. Over the 12-year study period, among the 233 patients included, 133 were NYHA III-IV and 179 Mayo 2004 III. The independent predictors for mortality identified were hsTnT, NT-proBNP, cardiac output, and conjugated bilirubin. A novel prognostic, conditional stratification, Mondor amyloidosis cardiac staging (MACS) was developed with biomarker cut-off values for Stage 1: hsTnT \u2264 107 ng\/L and NT-proBNP \u2264 3867 ng\/L (n = 77; 33%); for stage 2 NT-proBNP &amp;gt; 3867 ng\/L (n = 72; 30%). For stage 3, if troponin &amp;gt;107 ng\/L, regardless of NT-proBNP then CB 4 \u03bcmol\/L, was added (n = 41; 17.5%) and stage 4: CB &amp;gt; 4 \u03bcmol\/L (n = 43; 18.5%). The median overall survival was 8 months 95% CI [2\u201324]. At 1 year, 102 (44%) patients died and the Kaplan\u2013Meier median survival with MACS Stage 1 was not reached, while stage 2 was 15.2 months (95% CI [11\u201318]) and stage 3, 6.6 months (95% CI [1\u201313]). Notably, among European stage II patients, 17.1%, n = 8 were MACS stage 3 and European stage IIIb 21.4% (n = 23) were MACS stage 4. Importantly, among European stage IIIb patients 42.2% (n = 29) were classified MACS stage 4 and 12.5% n = 9 were only MACS stage 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The Mondor prognostic staging system, including conjugate bilirubin may significantly improve prognostic stratification for patients with severe cardiac amyloidosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14671","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:15:06Z","timestamp":1709684106000},"page":"1707-1719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic Mortality Factors in Advanced Light Chain Cardiac Amyloidosis: A Prospective Cohort Study"],"prefix":"10.1093","volume":"11","author":[{"given":"Amira","family":"Zaroui","sequence":"first","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]},{"name":"Clinical Epidemiology and Ageing (CEpiA) Geriatrics, Primary Care and Public Health , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounira","family":"Kharoubi","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]},{"name":"Univ Paris Est Cr\u00e9teil (UPEC), National Institute of Medical Research (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB) , Cr\u00e9teil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Gounot","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Lymphoid Malignancies Unit, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Oghina","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Degoutte","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Lymphoid Malignancies Unit, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Bezard","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]},{"name":"Univ Paris Est Cr\u00e9teil (UPEC), National Institute of Medical Research (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB) , Cr\u00e9teil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnault","family":"Galat","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soulef","family":"Guendouz","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Roulin","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Univ Paris Est Cr\u00e9teil (UPEC), National Institute of Medical Research (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB) , Cr\u00e9teil ,","place":["France"]},{"name":"Lymphoid Malignancies Unit, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Audard","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Assistance Publique des H\u00f4pitaux de Paris (AP-HP), Nephrology and Renal Transplantation Department, Henri Mondor Teaching Hospital, Rare Disease Reference Centre for Idiopathic Nephrotique Syndrome, University Hospital Federation for Innovative Therapy for Immune Disorders , Cr\u00e9teil ,","place":["France"]},{"name":"Department of Epidemiology, Toulouse Teaching Hospital , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Leroy","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Department of Hepatology, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Teiger","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]},{"name":"Univ Paris Est Cr\u00e9teil (UPEC), National Institute of Medical Research (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB) , Cr\u00e9teil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Poullot","sequence":"additional","affiliation":[{"name":"Department of Pathology, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Molinier-Frenkel","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Department of Immunology, LBMR Immunoglobulin deposit diseases and amyloses, France Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Le Bras","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Lymphoid Malignancies Unit, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Belhadj","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Lymphoid Malignancies Unit, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Bastard","sequence":"additional","affiliation":[{"name":"Biochemistry Department Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Fellahi","sequence":"additional","affiliation":[{"name":"Biochemistry Department Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Shourick","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Toulouse Teaching Hospital , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Lemonier","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Univ Paris Est Cr\u00e9teil (UPEC), National Institute of Medical Research (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB) , Cr\u00e9teil ,","place":["France"]},{"name":"Lymphoid Malignancies Unit, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-3848","authenticated-orcid":false,"given":"Thibaud","family":"Damy","sequence":"additional","affiliation":[{"name":"French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, and DHU A-TVB, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Henri Mondor Teaching Hospital , Creteil ,","place":["France"]},{"name":"Clinical Epidemiology and Ageing (CEpiA) Geriatrics, Primary Care and Public Health , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"2026012113025298200_ehf214671-bib-0001","first-page":"45","article-title":"Primary systemic amyloidosis: Clinical and laboratory features in 474 cases","volume":"32","author":"Kyle","year":"1995","journal-title":"Semin Hematol"},{"key":"2026012113025298200_ehf214671-bib-0002","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2023-002310","article-title":"Prognosis of light chain amyloidosis: A multivariable analysis for survival prediction in patients with cardiac involvement proven by endomyocardial biopsy. Open","volume":"10","author":"Aurich","year":"2023","journal-title":"Heart"},{"key":"2026012113025298200_ehf214671-bib-0003","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1161\/01.RES.0000126569.75419.74","article-title":"Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress","volume":"94","author":"Brenner","year":"2004","journal-title":"Circ Res"},{"key":"2026012113025298200_ehf214671-bib-0004","doi-asserted-by":"publisher","first-page":"5126","DOI":"10.1182\/blood-2010-06-290668","article-title":"Serum immunoglobulin free light-chain measurement in primary amyloidosis: Prognostic value and correlations with clinical features","volume":"116","author":"Kumar","year":"2010","journal-title":"Blood"},{"key":"2026012113025298200_ehf214671-bib-0005","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1182\/blood-2017-02-767467","article-title":"Patients with light-chain amyloidosis and low free light-chain burden have distinct clinical features and outcome","volume":"130","author":"Milani","year":"2017","journal-title":"Blood"},{"key":"2026012113025298200_ehf214671-bib-0006","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/s41408-021-00529-w","article-title":"Marked progress in AL amyloidosis survival: A 40-year longitudinal natural history study","volume":"11","author":"Staron","year":"2021","journal-title":"Blood Cancer J"},{"key":"2026012113025298200_ehf214671-bib-0007","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1111\/bjh.16096","article-title":"Ten-year survivors in AL amyloidosis: Characteristics and treatment pattern","volume":"187","author":"Muchtar","year":"2019","journal-title":"Br J Haematol"},{"key":"2026012113025298200_ehf214671-bib-0008","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1182\/blood-2018-06-858951","article-title":"Development and validation of a survival staging system incorporating BNP in patients with light chain amyloidosis","volume":"133","author":"Lilleness","year":"2019","journal-title":"Blood"},{"key":"2026012113025298200_ehf214671-bib-0009","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1182\/blood-2014-04-570010","article-title":"A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis","volume":"124","author":"Palladini","year":"2014","journal-title":"Blood"},{"key":"2026012113025298200_ehf214671-bib-0010","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.1182\/blood-2012-12-473066","article-title":"A European collaborative study of treatment outcomes in 346 patients with cardiac stage III AL amyloidosis","volume":"121","author":"Wechalekar","year":"2013","journal-title":"Blood"},{"key":"2026012113025298200_ehf214671-bib-0011","doi-asserted-by":"publisher","first-page":"4319","DOI":"10.1200\/JCO.2013.50.8499","article-title":"Coexistent multiple myeloma or increased bone marrow plasma cells define equally high-risk populations in patients with immunoglobulin light chain amyloidosis","volume":"31","author":"Kourelis","year":"2013","journal-title":"J Clin Oncol"},{"key":"2026012113025298200_ehf214671-bib-0012","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1200\/JCO.2011.38.5724","article-title":"Revised prognostic staging system for light chain amyloidosis incorporating cardiac biomarkers and serum free light chain measurements","volume":"30","author":"Kumar","year":"2012","journal-title":"J Clin Oncol"},{"key":"2026012113025298200_ehf214671-bib-0013","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257189","article-title":"Dexamethasone is associated with early deaths in light chain amyloidosis patients with severe cardiac involvement","volume":"16","author":"Bezard","year":"2021","journal-title":"PLoS ONE"},{"key":"2026012113025298200_ehf214671-bib-0014","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1080\/13506129.2017.1330744","article-title":"How your ears can tell what is hidden in your heart: Wild-type transthyretin amyloidosis as potential cause of sensorineural hearing loss inelderly-AmyloDEAFNESS pilot study","volume":"24","author":"B\u00e9quignon","year":"2017","journal-title":"Amyloid"},{"key":"2026012113025298200_ehf214671-bib-0015","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: A report from the american society of echocardiography developed in collaboration with the society for cardiovascular magnetic resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"2026012113025298200_ehf214671-bib-0016","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026012113025298200_ehf214671-bib-0017","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1515\/cclm-2016-1024","article-title":"Circulating free light chain measurement in the diagnosis, prognostic assessment and evaluation of response of AL amyloidosis: Comparison of Freelite and N Latex FLC assays","volume":"55","author":"Palladini","year":"2017","journal-title":"Clin Chem Lab Med"},{"key":"2026012113025298200_ehf214671-bib-0018","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1198\/106186006X133933","article-title":"Unbiased recursive partitioning: A conditional inference framework","volume":"15","author":"Hothorn","year":"2006","journal-title":"J Comput Graph Stat"},{"key":"2026012113025298200_ehf214671-bib-0019","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1001753","article-title":"Prognostic implication of longitudinal changes of left ventricular global strain after chemotherapy in cardiac light chain amyloidosis","volume":"9","author":"Bak","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2026012113025298200_ehf214671-bib-0020","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.jcmg.2016.04.008","article-title":"Prognosis of light chain amyloidosis with preserved LVEF: Added value of 2D speckle-tracking echocardiography to the current prognostic staging system","volume":"10","author":"Barros-Gomes","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026012113025298200_ehf214671-bib-0021","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2021-001808","article-title":"Prevalence and haemodynamic profiles of pulmonary hypertension in cardiac amyloidosis","volume":"9","author":"Slivnick","year":"2022","journal-title":"Open Heart"},{"key":"2026012113025298200_ehf214671-bib-0022","doi-asserted-by":"publisher","first-page":"588","DOI":"10.7150\/ijms.61712","article-title":"Prognostic factors of AL-PCMM and AL-MM: A single-center retrospective study","volume":"19","author":"Xu","year":"2022","journal-title":"Int J Med Sci"},{"key":"2026012113025298200_ehf214671-bib-0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2019.106226","article-title":"Clinical presentation and prognostic analysis of Chinese patients with systemic light chain amyloidosis with liver involvement","volume":"86","author":"Zhang","year":"2019","journal-title":"Leuk Res"},{"key":"2026012113025298200_ehf214671-bib-0024","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1159\/000508287","article-title":"Prognosis and staging of AL amyloidosis","volume":"143","author":"Dittrich","year":"2020","journal-title":"Acta Haematol"},{"key":"2026012113025298200_ehf214671-bib-0025","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/s41409-020-0990-6","article-title":"Prognostic value of NT-proBNP and troponin T in patients with light chain amyloidosis and kidney dysfunction undergoing autologous stem cell transplantation","volume":"56","author":"Al Saleh","year":"2021","journal-title":"Bone Marrow Transplant"},{"key":"2026012113025298200_ehf214671-bib-0026","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1136\/heartjnl-2013-304957","article-title":"High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis","volume":"100","author":"Dispenzieri","year":"2014","journal-title":"Heart"},{"key":"2026012113025298200_ehf214671-bib-0027","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1182\/blood-2010-02-267708","article-title":"Assessment of disease severity and outcome in patients with systemic light-chain amyloidosis by the high-sensitivity troponin T assay","volume":"116","author":"Kristen","year":"2010","journal-title":"Blood"},{"key":"2026012113025298200_ehf214671-bib-0028","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.amjcard.2012.05.061","article-title":"Clinical and echocardiographic correlates of elevated troponin in amyloid light-chain cardiac amyloidosis","volume":"110","author":"Apridonidze","year":"2012","journal-title":"Am J Cardiol"},{"key":"2026012113025298200_ehf214671-bib-0029","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.amjcard.2005.05.057","article-title":"Is elevated plasma B-natriuretic peptide in amyloidosis simply a function of the presence of heart failure?","volume":"96","author":"Nordlinger","year":"2005","journal-title":"Am J Cardiol"},{"key":"2026012113025298200_ehf214671-bib-0030","doi-asserted-by":"publisher","first-page":"3426","DOI":"10.1182\/blood-2010-05-286567","article-title":"The combination of high-sensitivity cardiac troponin T (hs-cTnT) at presentation and changes in N-terminal natriuretic peptide type B (NT-proBNP) after chemotherapy best predicts survival in AL amyloidosis","volume":"116","author":"Palladini","year":"2010","journal-title":"Blood"},{"key":"2026012113025298200_ehf214671-bib-0031","doi-asserted-by":"publisher","first-page":"8552","DOI":"10.1038\/s41598-019-44912-x","article-title":"Predictors of mortality in light chain cardiac amyloidosis with heart failure","volume":"9","author":"Tahir","year":"2019","journal-title":"Sci Rep"},{"key":"2026012113025298200_ehf214671-bib-0032","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1515\/CCLM.2011.624","article-title":"N Latex FLC - New monoclonal high-performance assays for the determination of free light chain kappa and lambda","volume":"49","author":"Velthuis","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"2026012113025298200_ehf214671-bib-0033","doi-asserted-by":"publisher","first-page":"4700","DOI":"10.1182\/blood-2007-11-122101","article-title":"Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared with monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability","volume":"111","author":"Bochtler","year":"2008","journal-title":"Blood"},{"key":"2026012113025298200_ehf214671-bib-0034","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1093\/ajcp\/aqw079","article-title":"Comparison of free light chain assays: \u2009Freelite and N Latex in diagnosis, monitoring, and predicting survival in light chain amyloidosis","volume":"146","author":"Mahmood","year":"2016","journal-title":"Am J Clin Pathol"},{"key":"2026012113025298200_ehf214671-bib-0035","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1515\/cclm-2018-1369","article-title":"Prognostic value of involved\/uninvolved free light chain ratio determined by Freelite and N Latex FLC assays for identification of high-risk smoldering myeloma patients","volume":"57","author":"Henriot","year":"2019","journal-title":"Clin Chem Lab Med"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/11\/3\/1707\/64070569\/eschf_11_3_1707.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/11\/3\/1707\/64070569\/eschf_11_3_1707.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:03:03Z","timestamp":1769018583000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/11\/3\/1707\/8234034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,5]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,5]]},"published-print":{"date-parts":[[2024,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.14671","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6]]},"published":{"date-parts":[[2024,3,5]]},"assertion":[{"value":"2023-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}