{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:05:13Z","timestamp":1790453113102,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":622,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Acute mitral regurgitation (MR) in the setting of myocardial infarction (MI) may be the result of papillary muscle rupture (PMR). This condition is associated with high morbidity and mortality. We aim to evaluate the feasibility of transcatheter edge-to-edge mitral valve repair (TEER) in this acute setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed data from the International Registry of MitraClip in Acute Mitral Regurgitation following acute Myocardial Infarction (IREMMI) of 30 centres in Europe, North America, and the middle east. We included patients with post-MI PMR treated with TEER as a salvage procedure, and we evaluated immediate and 30-day outcomes. Twenty-three patients were included in this analysis (9 patients suffered complete papillary muscle rupture, 9 partial and 5 chordal rupture). The patients\u2019 mean age was 68 \u00b1 14 years. Patients were at high surgical risk with median EuroSCORE II 27% (IQR 16, 28) and 20 out of 23 (87% were in cardiogenic shock). All patients were treated with vasopressors, and 17 out of 23 patients required mechanical support. TEER procedure was performed on the median 6 days after the index MI date IQR (3, 11). Procedural success was achieved in 87% of patients. The grade of MR was significantly decreased after the procedure. MR reduction to 0 or 1 + was achieved in 13 patients (57%), to 2 + in 7 patients (30%), P &amp;lt; 0.01. V-Wave was reduced from 49 \u00b1 8 mmHg to 26 \u00b1 10 mmHg post-procedure, P &amp;lt; 0.01. Sixteen out of 23 patients (70%) were discharged from hospital and 5 of them required reintervention with surgical mitral valve replacement. No additional death at 1 year was documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TEER is a feasible therapy in critically ill patients with PMR due to a recent MI. TEER may have a role as salvage treatment or bridge to surgery in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14675","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T01:48:54Z","timestamp":1706838534000},"page":"1218-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Transcatheter Edge-to-Edge Repair in Papillary Muscle Injury Complicating Acute Myocardial Infarction"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-8919","authenticated-orcid":false,"given":"Dan","family":"Haberman","sequence":"first","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Affiliated to the Hebrew University , Jerusalem ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Est\u00e9vez-Loureiro","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology, Hospital \u00c1lvaro Cunqueiro , Vigo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Czarnecki","sequence":"additional","affiliation":[{"name":"Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto , Toronto ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, San Raffaele University Hospital , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Villablanca","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, The Center for Structural Heart Disease, Henry Ford Hospital , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Spargias","sequence":"additional","affiliation":[{"name":"Department of Transcatheter Heart Valves, HYGEIA Hospital , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Sudarsky","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Baruch Padeh Medical Center , Poriya ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leor","family":"Perl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Rabin Medical Center and the \u201cSackler\u201d, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fefer","sequence":"additional","affiliation":[{"name":"Leviev Heart Center, Sheba Medical Center & Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Manevich","sequence":"additional","affiliation":[{"name":"Department of Cardiology, E. Wolfson Medical Center, Holon and Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Masiero","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Nombela-Franco","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos, Instituto de Investigacion Sanitaria San Carlos, IdISSC , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lion","family":"Poles","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot, Affiliated to the Hebrew University , Jerusalem ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Caneiro-Queija","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology, Hospital \u00c1lvaro Cunqueiro , Vigo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bowers","sequence":"additional","affiliation":[{"name":"Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto , Toronto ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Schiavi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, San Raffaele University Hospital , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Melillo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, San Raffaele University Hospital , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chrissoheris","sequence":"additional","affiliation":[{"name":"Department of Transcatheter Heart Valves, HYGEIA Hospital , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Dvir","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Centre, Shaare Zedek Medical Center \/ The Eisenberg R&D Authority, Hebrew University , Jerusalem ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maisano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, San Raffaele University Hospital , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Taramasso","sequence":"additional","affiliation":[{"name":"HerzZentrum Hirslanden Z\u00fcrich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony","family":"Shuvy","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Centre, Shaare Zedek Medical Center \/ The Eisenberg R&D Authority, Hebrew University , Jerusalem ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"2026012113155399000_ehf214675-bib-0001","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.amjcard.2013.11.050","article-title":"Long-term prognostic value of mitral regurgitation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention","volume":"113","author":"L\u00f3pez-P\u00e9rez","year":"2014","journal-title":"Am J Cardiol"},{"key":"2026012113155399000_ehf214675-bib-0002","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.amjcard.2016.09.007","article-title":"Prognostic significance of ischemic mitral regurgitation on outcomes in acute ST-elevation myocardial infarction managed by primary percutaneous coronary intervention","volume":"119","author":"Mentias","year":"2017","journal-title":"Am J Cardiol"},{"key":"2026012113155399000_ehf214675-bib-0003","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1161\/01.Cir.0000151097.30779.04","article-title":"Heart failure and death after myocardial infarction in the community: The emerging role of mitral regurgitation","volume":"111","author":"Bursi","year":"2005","journal-title":"Circulation"},{"key":"2026012113155399000_ehf214675-bib-0004","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1161\/01.cir.96.3.827","article-title":"Clinical significance of mitral regurgitation after acute myocardial infarction. Survival and ventricular enlargement investigators","volume":"96","author":"Lamas","year":"1997","journal-title":"Circulation"},{"key":"2026012113155399000_ehf214675-bib-0005","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/j.jcin.2019.04.039","article-title":"Temporal trends and outcomes of mechanical complications in patients with acute myocardial infarction","volume":"12","author":"Elbadawi","year":"2019","journal-title":"JACC Cardiovasc Interv"},{"key":"2026012113155399000_ehf214675-bib-0006","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1161\/CIR.0000000000000985","article-title":"Mechanical complications of acute myocardial infarction: A scientific statement from the American Heart Association","volume":"144","author":"Damluji","year":"2021","journal-title":"Circulation"},{"key":"2026012113155399000_ehf214675-bib-0007","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/S0735-1097(00)00879-2","article-title":"Cardiogenic shock complicating acute myocardial infarction\u2014etiologies, management and outcome: A report from the SHOCK trial registry","volume":"36","author":"Hochman","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2026012113155399000_ehf214675-bib-0008","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcin.2020.08.037","article-title":"Transcatheter mitral valve repair in cardiogenic shock and mitral regurgitation: A patient-level, multicenter analysis","volume":"14","author":"Jung","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"2026012113155399000_ehf214675-bib-0009","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/jcm10091819jcm10091819","article-title":"Safety and feasibility of MitraClip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction","author":"Haberman","year":"2021","journal-title":"J Clin Med"},{"key":"2026012113155399000_ehf214675-bib-0010","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1002\/ejhf.1565","article-title":"Salvage MitraClip in severe secondary mitral regurgitation complicating acute myocardial infarction: Data from a multicentre international study","volume":"21","author":"Haberman","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2026012113155399000_ehf214675-bib-0011","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.4244\/EIJ-D-19-00653","article-title":"Transcatheter mitral valve repair in patients with acute myocardial infarction: Insights from the European registry of MitraClip in acute mitral regurgitation following an acute myocardial infarction (EREMMI)","volume":"15","author":"Estevez-Loureiro","journal-title":"EuroIntervention"},{"key":"2026012113155399000_ehf214675-bib-0012","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1093\/eurheartj\/ehab4966360026","article-title":"Conservative, surgical, and percutaneous treatment for mitral regurgitation shortly after acute myocardial infarction","volume":"43","author":"Haberman","year":"2022","journal-title":"Eur Heart J"},{"key":"2026012113155399000_ehf214675-bib-0013","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"2026012113155399000_ehf214675-bib-0014","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native Valvular regurgitation: A report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"2026012113155399000_ehf214675-bib-0015","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.amjcard.2009.08.653","article-title":"Mechanical complications after percutaneous coronary intervention in ST-elevation myocardial infarction (from APEX-AMI)","volume":"105","author":"French","year":"2010","journal-title":"Am J Cardiol"},{"key":"2026012113155399000_ehf214675-bib-0016","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.amjcard.2019.12.051","article-title":"Outcomes and hospital utilization in patients with papillary muscle rupture associated with acute myocardial infarction","volume":"125","author":"Bhardwaj","year":"2020","journal-title":"Am J Cardiol"},{"key":"2026012113155399000_ehf214675-bib-0017","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s13019-014-0171-z","article-title":"Predictors of in-hospital mortality after mitral valve surgery for post-myocardial infarction papillary muscle rupture","volume":"9","author":"Bouma","year":"2014","journal-title":"J Cardiothorac Surg"},{"key":"2026012113155399000_ehf214675-bib-0018","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.ejcts.2007.12.050","article-title":"Mitral valve surgery in emergency for severe acute regurgitation: Analysis of postoperative results from a multicentre study","volume":"33","author":"Lorusso","year":"2008","journal-title":"Eur J Cardiothorac Surg"},{"key":"2026012113155399000_ehf214675-bib-0019","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytz001","article-title":"Edge-to-edge mitral valve repair for acute mitral valve regurgitation due to papillary muscle rupture: A case report","volume":"3","author":"Papadopoulos","year":"2019","journal-title":"Eur Heart J Case Rep"},{"key":"2026012113155399000_ehf214675-bib-0020","doi-asserted-by":"publisher","first-page":"e1413","DOI":"10.1016\/j.cjca.2014.07.015","article-title":"MitraClip for papillary muscle rupture in patient with cardiogenic shock","volume":"30","author":"Wolff","year":"2014","journal-title":"Can J Cardiol"},{"key":"2026012113155399000_ehf214675-bib-0021","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1080\/24748706.2019.1618513","article-title":"Successful MitraClip XTR for torrential mitral regurgitation secondary to papillary muscle rupture as a complication of acute myocardial infarction","volume":"3","author":"Villablanca","year":"2019","journal-title":"Structural Heart"},{"key":"2026012113155399000_ehf214675-bib-0022","doi-asserted-by":"publisher","first-page":"E137","DOI":"10.1002\/ccd.24960","article-title":"Successful percutaneous mitral valve repair with the MitraClip system of acute mitral regurgitation due to papillary muscle rupture as complication of acute myocardial infarction","volume":"83","author":"Bilge","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"key":"2026012113155399000_ehf214675-bib-0023","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1016\/j.athoracsur.2014.09.075","article-title":"MitraClip implantation after acute ischemic papillary muscle rupture in a patient with prolonged cardiogenic shock","volume":"99","author":"Bahlmann","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"2026012113155399000_ehf214675-bib-0024","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.rec.2014.10.009S1885-5857(14)00459-9","article-title":"Percutaneous mitral valve repair with MitraClip system in a patient with acute mitral regurgitation after myocardial infarction","volume":"68","author":"Rodriguez-Santamarta","year":"2015","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2026012113155399000_ehf214675-bib-0025","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005050","article-title":"Acute mitral regurgitation secondary to papillary muscle tear: Is Transcatheter edge-to-edge mitral valve repair a new paradigm?","volume":"10","author":"Valle","year":"2017","journal-title":"Circ Cardiovasc Interv"},{"key":"2026012113155399000_ehf214675-bib-0026","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1016\/j.cjca.2019.06.024","article-title":"Transcatheter mitral valve edge-to-edge repair with the new MitraClip XTR system for acute mitral regurgitation caused by papillary muscle rupture","volume":"35","author":"Komatsu","year":"2019","journal-title":"Can J Cardiol"},{"key":"2026012113155399000_ehf214675-bib-0027","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.carrev.2022.07.003","article-title":"Transcatheter edge-to-edge repair for acute mitral regurgitation with cardiogenic shock secondary to mechanical complication","volume":"45","author":"So","year":"2022","journal-title":"Cardiovasc Revasc Med"},{"key":"2026012113155399000_ehf214675-bib-0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscai.2022.100431","article-title":"Transcatheter edge-to-edge repair for acute mitral regurgitation due to postinfarction papillary muscle rupture","volume":"1","author":"Chang","year":"2022","journal-title":"J Soc Cardiovasc Angiograph Interv"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/11\/2\/1218\/64540050\/eschf_11_2_1218.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/11\/2\/1218\/64540050\/eschf_11_2_1218.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:17:53Z","timestamp":1769019473000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/11\/2\/1218\/8271346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,1]]},"published-print":{"date-parts":[[2024,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.14675","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"2023-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}