{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:40:58Z","timestamp":1791319258598,"version":"4.3.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":600,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["20K17087"],"award-info":[{"award-number":["20K17087"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K08476"],"award-info":[{"award-number":["20K08476"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pfizer Japan Incorporated"},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K08476"],"award-info":[{"award-number":["20K08476"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>There are minimal data on the prognostic impact of right atrial strain during the reservoir phase (RASr) in patients with immunoglobulin light-chain (AL) cardiac amyloidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Among 78 patients who were diagnosed with AL cardiac amyloidosis at Kumamoto University Hospital from 2007 to 2022, 72 patients with sufficient two-dimensional speckle tracking imaging data without chemotherapy before the diagnosis were retrospectively analysed. During a median follow-up of 403 days, 31 deaths occurred. Age and the rate of male sex were not significantly different between the all-cause death group and the survival group (age, 70.4 \u00b1 8.8 years vs. 67.0 \u00b1 10.0 years, P = 0.14, male sex, 65% vs. 66%, P = 0.91). The estimated glomerular filtration rate (eGFR) was significantly lower, and B-type natriuretic peptide (BNP) and high sensitivity cardiac troponin T (hs-cTnT) were significantly higher, in the all-cause death group versus the survival group (eGFR, 48.2 \u00b1 21.0 mL\/min\/1.73 m2 vs. 59.4 \u00b1 24.4 mL\/min\/1.73 m2, P &amp;lt; 0.05, BNP, 725 [360\u20131312] pg\/mL vs. 123 [81\u2013310] pg\/mL, P &amp;lt; 0.01, hs-cTnT, 0.12 [0.07\u20130.18] ng\/mL vs. 0.05 [0.03\u20130.08] ng\/mL, P &amp;lt; 0.01). Left ventricular (LV) global longitudinal strain (GLS) (LV-GLS), left atrial strain during the reservoir phase (LASr), right ventricular GLS (RV-GLS), and RASr were significantly lower in the all-cause death group versus the survival group (LV-GLS, 8.5 \u00b1 4.3% vs. 11.8 \u00b1 3.8%, P &amp;lt; 0.01, LASr, 8.8 \u00b1 7.1% vs. 14.3 \u00b1 8.1%, P &amp;lt; 0.01, RV-GLS, 11.6 \u00b1 5.1% vs. 16.4 \u00b1 3.9%, P &amp;lt; 0.01, RASr, 10.2 \u00b1 7.3% vs. 20.7 \u00b1 9.5%, P &amp;lt; 0.01). RASr was significantly associated with all-cause death after adjusting for RV-GLS, LV-GLS and LASr (hazard ratio [HR]: 0.91, 95% confidence interval [95% CI]: 0.83\u20130.99, P &amp;lt; 0.05). RASr and log-transformed BNP were significantly associated with all-cause death after adjusting for log-transformed troponin T and eGFR (RASr, HR: 0.93, 95% CI: 0.87\u20131.00, P &amp;lt; 0.05; log-transformed BNP, HR: 2.10, 95% CI: 1.17\u20133.79, P &amp;lt; 0.05). The optimal cut-off values were RASr: 16.4% (sensitivity: 66%, specificity: 84%, area under curve [AUC]: 0.81) and BNP: 311.2 pg\/mL (sensitivity: 83%, specificity: 78%, AUC: 0.82) to predict all-cause mortality using ROC analysis. Kaplan\u2013Meier analysis revealed that patients with low RASr (&amp;lt;16.4%) or high BNP (&amp;gt;311.2 pg\/mL) had a significantly high probability of all-cause death (both, P &amp;lt; 0.01). We devised a new staging score by adding 1 point if RASr decreased or BNP levels increased more than each cut-off value. The HR for all-cause death using score 0 as a reference was 5.95 (95% CI: 1.19\u201329.79; P &amp;lt; 0.05) for score 1 and 23.29 (95% CI: 5.37\u2013100.98; P &amp;lt; 0.01) for score 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The new staging system using RASr and BNP predicted prognosis in patients with AL cardiac amyloidosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14710","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T02:39:10Z","timestamp":1708742350000},"page":"1612-1624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A New Staging System Using Right Atrial Strain in Patients with Immunoglobulin Light-Chain Cardiac Amyloidosis"],"prefix":"10.1093","volume":"11","author":[{"given":"Hiroki","family":"Usuku","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Kumamoto University Hospital , Kumamoto ,","place":["Japan"]},{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , Kumamoto ,","place":["Japan"]},{"name":"Center of Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences , Kumamoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , Kumamoto ,","place":["Japan"]},{"name":"Center of Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences , Kumamoto 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