{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:29:05Z","timestamp":1791217745184,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":558,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Right ventricular failure after left ventricular assist device (LVAD) implantation is a major concern that remains challenging to predict. We sought to investigate the relationship between preoperative pulmonary artery pulsatility index (PAPi) and mortality after LVAD implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A retrospective analysis of the ASSIST-ICD multicentre registry allowed the assessment of PAPi before LVAD according to the formula [(systolic pulmonary artery pressure \u2212 diastolic pulmonary artery pressure)\/central venous pressure]. The primary endpoint was survival at 3 months, according to the threshold value of PAPi determined by the receiver operating characteristic (ROC) curve. A multivariate analysis including demographic, echographic, haemodynamic, and biological variables was performed to identify predictive factors for 2 year mortality. One hundred seventeen patients were included from 2007 to 2021. The mean age was 58.45 years (\u00b113.16), with 15.4% of women (sex ratio 5.5). A total of 53.4% were implanted as bridge to transplant and 43.1% as destination therapy. Post-operative right ventricular failure was observed in 57 patients (48.7%), with no significant difference between survivors and non-survivors at 1 month (odds ratio 1.59, P = 0.30). The median PAPi for the whole study population was 2.83 [interquartile range 1.63\u20134.69]. The threshold value of PAPi determined by the ROC curve was 2.84. Patients with PAPi \u2265 2.84 had a higher survival rate at 3 months [PAPi &amp;lt; 2.84: 58.1% [46.3\u201372.8%] vs. PAPi \u2265 2.84: 89.1% [81.1\u201397.7%], hazard ratio (HR) 0.08 [0.02\u20130.28], P &amp;lt; 0.01], with no significant difference after 3 months (HR 0.67 [0.17\u20132.67], P = 0.57). Other predictors of 2 year mortality were systemic hypertension (HR 4.22 [1.49\u201311.97], P &amp;lt; 0.01) and diabetes mellitus (HR 4.90 [1.83\u201313.14], P &amp;lt; 0.01). LVAD implantation as bridge to transplant (HR 0.18 [0.04\u20130.74], P = 0.02) and heart transplantation (HR 0.02 [0.00\u20130.18], P &amp;lt; 0.01) were associated with a higher survival rate at 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative PAPi &amp;lt; 2.84 was associated with a higher risk of early mortality after LVAD implantation without impacting 2 year outcomes among survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14716","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T01:40:52Z","timestamp":1712367652000},"page":"2100-2112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association Between Pulmonary Artery Pulsatility and Mortality After Implantation of Left Ventricular Assist Device"],"prefix":"10.1093","volume":"11","author":[{"given":"Ali","family":"Akamkam","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph , Le Plessis-Robinson ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Galand","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Rennes, CHU Rennes , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Jungling","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lille University Hospital, Heart-Lung Institute , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Delmas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Toulouse , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Dambrin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital of Toulouse , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Pernot","sequence":"additional","affiliation":[{"name":"Haut-L\u00e9v\u00eaque Cardiological Hospital, Bordeaux II University , Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Kindo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospitals of Strasbourg , Strasbourg ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gaudard","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, PhyMedExp, University of Montpellier, INSERM, 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