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Recent studies in persons with chronic kidney disease (CKD) demonstrate that iron deficiency is associated with incident HF. This study aimed to determine the relationship of iron status with incident HF in community-dwelling older adults irrespective of their kidney function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this case-cohort study, 1,006 Cardiovascular Health Study participants (785 from the random sub-cohort [including 193 HF cases] and 221 additional HF cases [N = 414 total HF cases]) aged \u2265 65 years without HF (41% with CKD), we used weighted Cox models to evaluate associations of iron status with incident HF. Participants were categorized based on quartiles of transferrin saturation and ferritin as \u201ciron replete\u201d (27.3%), \u201cfunctional iron deficiency\u201d (7.7%), \u201ciron deficiency\u201d (11.8%), \u201cmixed iron deficiency\u201d (5.6%), \u201chigh iron\u201d (9.3%) and \u201cnon-classified\u201d (38.1%), consistent with prior studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to older persons who were iron replete, those with iron deficiency were at higher risk of incident HF (HR 1.47; 1.02\u20132.11) in models adjusting for demographics, HF risk factors, and estimated glomerular filtration rate. Other iron categories did not associate with incident HF. The relationship of iron deficiency with incident HF did not differ by CKD status (interaction P value 0.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among community-dwelling elders, iron deficiency is independently associated with incident HF, an association that was similar irrespective of CKD status. Our findings support conduct of clinical trials of iron replacement for prevention of HF in older adults with iron deficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14724","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T06:00:09Z","timestamp":1708927209000},"page":"1435-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Iron Deficiency and Incident Heart Failure in Older Community-Dwelling Individuals"],"prefix":"10.1093","volume":"11","author":[{"given":"Shilpa","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Medicine, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["USA"]},{"name":"Nephrology Section, Veteran Affairs Greater Los Angeles Healthcare System , Los Angeles, CA 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