{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:15:16Z","timestamp":1791461716433,"version":"4.3.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":550,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Else-Kr\u00f6ner-Fresenius-Stiftung, Bad Homburg, Germany"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Transthyretin \u2018wild-type\u2019 amyloid cardiomyopathy (ATTRwt-CM) is a differential diagnosis of heart failure with preserved ejection fraction (HFpEF). The clinical work-up for ATTRwt-CM is challenging. Considering a combination of clinical variables specific for ATTRwt-CM might aid in identifying patients at risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Sixty patients (78 \u00b1 6 years, 8% female) were diagnosed with ATTRwt-CM by endomyocardial biopsy. Preserved ejection fraction (LVEF &amp;gt;45%) was present in 41 of the patients. Those were 1:1 propensity score age- and sex-matched to a cohort of patients with HFpEF. ATTRwt-CM patients had less obesity (P = 0.01) and higher septal thickness (IVSd, P &amp;lt; 0.01) as well as more diastolic dysfunction (E\/e\u2032, P &amp;lt; 0.01). On multivariable regression IVSd &amp;gt; 14 mm, E\/e\u2032 &amp;gt; 14 and absence of obesity (P &amp;gt; 0.01 for all) were identified as predictors for ATTRwt-CM. A weighted point-based score was derived with IVSd &amp;gt; 14 mm = 1 point; absence of obesity = 2 points; and E\/e\u2032 &amp;gt; 14 = 3 points. Area under the curve (AUC) for the summation score was 0.91 (0.84\u20130.97, P &amp;lt; 0.01) and a score of more than 3 points predicted ATTRwt-CM with good sensitivity (78%) and specificity (90%). The score was validated in an external cohort of 142 patients with ATTRwt-CM and 419 HFpEF patients showing sufficient accuracy (AUC 0.91, 0.88\u20130.94, P &amp;lt; 0.01). A value greater than 3 points demonstrated a high sensitivity (93%) and a negative predictive value of 97%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A score based on basic clinical and echocardiographic features helps to distinguish ATTRwt-CM from typical HFpEF. This could facilitate the diagnostic work-up for these patients and enable earlier disease screening on a large scale.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14786","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T06:04:58Z","timestamp":1712988298000},"page":"2172-2181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Transthyretin Amyloid Cardiomyopathy Among Patients with Heart Failure and Preserved Ejection Fraction: The AMY Score"],"prefix":"10.1093","volume":"11","author":[{"given":"Guglielmo","family":"Gioia","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin\/Kardiologie, Herzzentrum Leipzig - Universit\u00e4t Leipzig , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lore","family":"Schrutka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, 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