{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:48:36Z","timestamp":1790423316492,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":518,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Capital Funds for Health Improvement and Research","award":["2022-2-2066"],"award-info":[{"award-number":["2022-2-2066"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The efficacy and safety of new-generation devices (NGDs) for severe aortic regurgitation (AR) have mostly been based on single-arm studies with limited sample sizes. Our goal was to summarize the current evidence on NGDs and compare the safety and efficacy of \u2018off-label\u2019 and \u2018on-label\u2019 devices in NGDs. We searched MEDLINE, Embase, Cochrane Library, and Scopus for articles on transcatheter aortic valve replacement in patients with AR. A total of 31 studies that included 1851 patients were identified through April 2023. Among these, 1067 (57.6%) patients received treatment with \u2018on-label\u2019 devices (JenaValve and J-Valve). For NGDs, the total device success rate at 30 days was 94.5% (on-label: 97.8%, off-label: 89.9%; P &amp;lt; 0.001), the all-cause mortality was 4.2% (on-label: 2.6%, off-label: 5.1%; P = 0.006), permanent pacemaker implantation (PPI) was 8.8% (on-label: 6.9%, off-label: 18.4%; P &amp;lt; 0.001), and the rate of greater-than-mild paravalvular leak (PVL) was 1.2% (on-label: 0.9%, off-label: 3.8%; P = 0.003). On-label devices showed significantly better safety and efficacy in terms of the success rate, PPI, greater-than-mild PVL, and 30 day mortality than off-label devices.<\/jats:p>","DOI":"10.1002\/ehf2.14832","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T20:03:20Z","timestamp":1715803400000},"page":"3488-3500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Transcatheter Aortic Valve Replacement for Aortic Regurgitation: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"11","author":[{"given":"Ran","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Yan","sequence":"additional","affiliation":[{"name":"Center for Health Systems Research, Sutter Health , Sacramento, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"2026012113123126300_ehf214832-bib-0001","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/s0195-668x(03)00201-x","article-title":"A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur Heart J"},{"key":"2026012113123126300_ehf214832-bib-0002","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1056\/NEJMoa1400590","article-title":"Transcatheter aortic-valve replacement with a self-expanding prosthesis","volume":"370","author":"Adams","year":"2014","journal-title":"N Engl J Med"},{"key":"2026012113123126300_ehf214832-bib-0003","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a 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