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We identified differentially expressed genes (DEGs) and underlying molecular mechanisms using RNA sequencing technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>RNA sequencing was used to analyse DEGs in MI rat tissues and H9C2 cells exposed to hypoxia for 24 h. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were used to identify key biological processes and pathways. Weighted correlation network analysis [weighted gene co-expression network analysis (WGCNA)] was used to construct gene co-expression networks, and hub genes were compared with published MI datasets [Gene Expression Omnibus (GEO)] for target identification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GO analysis revealed enrichment of immune inflammation and mitochondrial respiration processes among 5139 DEGs in MI tissues and 2531 in H9C2 cells. KEGG analysis identified 537 overlapping genes associated with metabolism and oxidative stress pathways. Cross-analyses using the published GSE35088 and GSE47495 datasets identified 40 and 16 overlapping genes, respectively, with nine genes overlapping across all datasets and our models. WGCNA identified a key module in the MI model enriched for mRNA processing and protein binding. GO analysis revealed enrichment of mRNA processing, protein binding and mitochondrial respiratory chain complex I assembly in MI and H9C2 MH models. Five relevant hub genes were identified via a cross-analysis between the 92 hub genes that showed a common expression trend in both models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study reveals both shared and distinct transcriptomic responses in the MI and H9C2 models, highlighting the importance of model selection for studying myocardial ischaemia and hypoxia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14903","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T01:39:22Z","timestamp":1721093962000},"page":"3775-3795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptome Analysis of Myocardial Ischemic-Hypoxic Injury in Rats and Hypoxic H9C2 Cells"],"prefix":"10.1093","volume":"11","author":[{"given":"Nan","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, People's Hospital of Ningxia Hui Autonomous Region , Yinchuan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huangtai","family":"Miao","sequence":"additional","affiliation":[{"name":"Coronary Heart Disease Center, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, People's Hospital of Ningxia Hui Autonomous Region , Yinchuan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"2026012113120242600_ehf214903-bib-0001","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.atherosclerosis.2021.04.009","article-title":"Hysterectomy and ischemic heart disease: An observational study using propensity score methods in NHANES 2007\u20132018","volume":"327","author":"Wang","year":"2021","journal-title":"Atherosclerosis"},{"key":"2026012113120242600_ehf214903-bib-0002","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1161\/CIRCULATIONAHA.118.037137","article-title":"Twenty year trends and sex differences in young adults hospitalized with acute myocardial infarction","volume":"139","author":"Arora","year":"2019","journal-title":"Circulation"},{"key":"2026012113120242600_ehf214903-bib-0003","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1097\/HCO.0000000000000781","article-title":"Recent trends in acute myocardial infarction among the young","volume":"35","author":"Wu","year":"2020","journal-title":"Curr Opin Cardiol"},{"key":"2026012113120242600_ehf214903-bib-0004","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1175935","article-title":"miR-214-3p protects and restores the myocardial tissue of rat myocardial infarction model by targeting PTEN","volume":"2022","author":"Cheng","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"2026012113120242600_ehf214903-bib-0005","article-title":"Natural heart regeneration in a neonatal rat myocardial infarction model","volume":"9","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"2026012113120242600_ehf214903-bib-0006","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.regpep.2012.08.013","article-title":"Myocardial angiogenesis after chronic ghrelin treatment in a rat myocardial infarction model","volume":"179","author":"Yuan","year":"2012","journal-title":"Regul Pept"},{"key":"2026012113120242600_ehf214903-bib-0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2020.151624","article-title":"Methods for histological characterization of cryo-induced myocardial infarction in a rat model","volume":"122","author":"Alonzo","year":"2020","journal-title":"Acta Histochem"},{"key":"2026012113120242600_ehf214903-bib-0008","doi-asserted-by":"publisher","DOI":"10.3791\/64387","article-title":"Left coronary artery ligation: A surgical murine model of myocardial infarction","volume":"186","author":"Johny","year":"2022","journal-title":"J Vis Exp"},{"key":"2026012113120242600_ehf214903-bib-0009","article-title":"Generation and characterization of right ventricular myocardial infarction induced by permanent ligation of the right coronary artery in mice","volume":"180","author":"Liao","year":"2022","journal-title":"J Vis Exp"},{"key":"2026012113120242600_ehf214903-bib-0010","doi-asserted-by":"publisher","DOI":"10.3791\/59591","article-title":"Murine myocardial infarction model using permanent ligation of left anterior descending coronary artery","volume":"150","author":"Lugrin","year":"2019","journal-title":"J Vis Exp"},{"key":"2026012113120242600_ehf214903-bib-0011","first-page":"212","article-title":"Irreversible injury of isolated adult rat myocytes. 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