{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:03:21Z","timestamp":1790654601577,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":448,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Chinese National Natural Science Foundation","doi-asserted-by":"publisher","award":["82170521"],"award-info":[{"award-number":["82170521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21ZR1449500"],"award-info":[{"award-number":["21ZR1449500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010032","name":"Foundation of Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202140263"],"award-info":[{"award-number":["202140263"]}],"id":[{"id":"10.13039\/501100010032","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tibet Natural Science Foundation of China","award":["XZ2022ZR-ZY27(Z)"],"award-info":[{"award-number":["XZ2022ZR-ZY27(Z)"]}]},{"name":"Tibet Natural Science Foundation of China","award":["XZ202301ZR0032G"],"award-info":[{"award-number":["XZ202301ZR0032G"]}]},{"name":"Foundation of Chongming","award":["CKY2021-21"],"award-info":[{"award-number":["CKY2021-21"]}]},{"name":"Foundation of Chongming","award":["CKY2020-29"],"award-info":[{"award-number":["CKY2020-29"]}]},{"name":"Clinical Research Plan of Shanghai Tenth People's Hospital","award":["YNCR2A001"],"award-info":[{"award-number":["YNCR2A001"]}]},{"name":"Clinical Research Plan of SHDC","award":["SHDC2020CR4065"],"award-info":[{"award-number":["SHDC2020CR4065"]}]},{"name":"Foundation of the Science and Technology Commission of Shanghai Municipality","award":["20dz1207200"],"award-info":[{"award-number":["20dz1207200"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170521"],"award-info":[{"award-number":["82170521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010032","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["202140263"],"award-info":[{"award-number":["202140263"]}],"id":[{"id":"10.13039\/501100010032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The fibrosis-4 index (FIB-4) is a non-invasive tool to assess fibrosis risk in chronic liver disease. We aimed to explore the relationship between the FIB-4 index and long-term major adverse cardiovascular events (MACE) in HCM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Consecutive patients diagnosed with HCM were included. Patients were divided into two groups using a defined cutoff value established through a ROC analysis for predicting MACE (FIB-4 \u2265 2.37 and FIB-4 &amp;lt; 2.37). The final analysis comprised 187 HCM patients (34.8% females, 66.49 \u00b1 11.43 years of age), with 47 (25.1%) in the FIB-4 \u2265 2.37 group and 140 (74.9%) in the FIB-4 &amp;lt; 2.37 group. Among these, 147 (78.6%) individuals had complete follow-up data. Patients with FIB-4 \u2265 2.37 demonstrated a higher prevalence of co-morbidities such as atrial fibrillation (27.7% vs. 7.9%; P &amp;lt; 0.001), heart failure (55.3% vs. 24.3%; P &amp;lt; 0.001), elevated NT-proBNP levels (3.03 \u00b1 4.74 vs. 0.66 \u00b1 1.08; P &amp;lt; 0.001), and lower LVEF (58.51 \u00b1 7.86 vs. 61.84 \u00b1 5.04; P = 0.001). Over a median of 41 (IQR 16\u201363) months follow-up, MACE occurred in 49 (33.3%), with a significantly higher incidence in the FIB-4 \u2265 2.37 group (58.8% vs. 25.7%, P &amp;lt; 0.001). Cardiac death rates were also elevated in the FIB-4 \u2265 2.37 group (20.6% vs. 2.7%, P = 0.001). Cox regression analysis revealed an independent association between FIB-4 \u2265 2.37 and a higher risk of MACE (adjusted HR: 1.919, 95% CI 1.015\u20133.630; P = 0.045) and cardiac death (adjusted HR: 9.518, 95% CI 1.718\u201352.732; P = 0.010). Furthermore, the FIB-4 index shows positive correlations with left atrium diameter (r = 0.229; P = 0.003), septal thickness (r = 0.231; P = 0.002), posterior wall thickness (r = 0.235; P = 0.001), and NT-proBNP (r = 0.271; P &amp;lt; 0.001). Conversely, a negative correlation was observed between the FIB-4 index and left ventricular ejection fraction (r = \u22120.185; P = 0.011).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated FIB-4 index, indicative of liver fibrosis, is independently associated with an increased risk of long-term MACE in HCM patients. This emphasizes the potential influence of liver function abnormalities on HCM prognosis, underscoring the need for comprehensive risk assessment in clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14977","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T02:51:54Z","timestamp":1721875914000},"page":"3934-3945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of Liver Fibrosis-4 Index with Adverse Outcomes in Hypertrophic Cardiomyopathy Patients"],"prefix":"10.1093","volume":"11","author":[{"given":"Fuad A.","family":"Abdu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redhwan M.","family":"Mareai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jassur.","family":"Galip","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul-Quddus","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman A.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]},{"name":"Department of Cardiology, Shanghai Tenth People's Hospital Chongming branch , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"2026012113123749900_ehf214977-bib-0001","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1161\/circresaha.117.311059","article-title":"Hypertrophic cardiomyopathy: Genetics, pathogenesis, clinical manifestations, diagnosis, and therapy","volume":"121","author":"Marian","year":"2017","journal-title":"Circ Res"},{"key":"2026012113123749900_ehf214977-bib-0002","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1161\/circresaha.121.318346","article-title":"Molecular genetic basis of hypertrophic cardiomyopathy","volume":"128","author":"Marian","year":"2021","journal-title":"Circ Res"},{"key":"2026012113123749900_ehf214977-bib-0003","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/s0140-6736(12)60397-3","article-title":"Hypertrophic cardiomyopathy","volume":"381","author":"Maron","year":"2013","journal-title":"Lancet (London, England)"},{"key":"2026012113123749900_ehf214977-bib-0004","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/ehjci\/jey135","article-title":"Progression of myocardial fibrosis in hypertrophic cardiomyopathy: Mechanisms and clinical implications","volume":"20","author":"Raman","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026012113123749900_ehf214977-bib-0005","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429x-14-76","article-title":"Diffuse myocardial fibrosis in hypertrophic cardiomyopathy can be identified by cardiovascular magnetic resonance, and is associated with left ventricular diastolic dysfunction","volume":"14","author":"Ellims","year":"2012","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026012113123749900_ehf214977-bib-0006","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.jcmg.2020.09.037","article-title":"Progression of myocardial fibrosis in hypertrophic cardiomyopathy: A cardiac magnetic resonance study","volume":"14","author":"Habib","year":"2021","journal-title":"J Am Coll Cardiol Img"},{"key":"2026012113123749900_ehf214977-bib-0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.102222","article-title":"Beyond the beat: A pioneering investigation into exercise modalities for alleviating diabetic cardiomyopathy and enhancing cardiac health","volume":"49","author":"Ahsan Riaz","year":"2023","journal-title":"Curr Probl Cardiol"},{"key":"2026012113123749900_ehf214977-bib-0008","doi-asserted-by":"publisher","first-page":"281","DOI":"10.5935\/abc.20190045","article-title":"Role of myocardial fibrosis in hypertrophic cardiomyopathy: A systematic review and updated meta-analysis of risk markers for sudden death","volume":"112","author":"Bittencourt","year":"2019","journal-title":"Arq Bras Cardiol"},{"key":"2026012113123749900_ehf214977-bib-0009","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/emmm.201302852","article-title":"Metabolic crosstalk between the heart and liver impacts familial hypertrophic cardiomyopathy","volume":"6","author":"Magida","year":"2014","journal-title":"EMBO Mol Med"},{"key":"2026012113123749900_ehf214977-bib-0010","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/emmm.201303800","article-title":"The heart-liver metabolic axis: Defective communication exacerbates disease","volume":"6","author":"Baskin","year":"2014","journal-title":"EMBO Mol Med"},{"key":"2026012113123749900_ehf214977-bib-0011","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1016\/j.transproceed.2018.02.080","article-title":"Hypertrophic cardiomyopathy in liver transplantation patients","volume":"50","author":"Pai","year":"2018","journal-title":"Transplant Proc"},{"key":"2026012113123749900_ehf214977-bib-0012","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13098-023-01031-y","article-title":"Fibrosis score 4 index has an independent relationship with coronary artery diseases in patients with metabolic-associated fatty liver disease","volume":"15","author":"Namakchian","year":"2023","journal-title":"Diabetol Metab Syndr"},{"key":"2026012113123749900_ehf214977-bib-0013","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s00392-022-02055-6","article-title":"Predictive value of the fibrosis-4 index in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"111","author":"Sudo","year":"2022","journal-title":"Clin Res Cardiol"},{"key":"2026012113123749900_ehf214977-bib-0014","doi-asserted-by":"publisher","first-page":"3809","DOI":"10.1002\/ehf2.13351","article-title":"Prognostic significance of liver stiffness assessed by fibrosis-4 index in patients with heart failure","volume":"8","author":"Takae","year":"2021","journal-title":"ESC Heart Failure"},{"key":"2026012113123749900_ehf214977-bib-0015","doi-asserted-by":"publisher","first-page":"e558","DOI":"10.1161\/cir.0000000000000937","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: A report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"142","author":"Ommen","year":"2020","journal-title":"Circulation"},{"key":"2026012113123749900_ehf214977-bib-0016","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: The task force for the diagnosis and management of hypertrophic cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"2026012113123749900_ehf214977-bib-0017","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations for chamber quantification: A report from the American Society of Echocardiography's guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology","volume":"18","author":"Lang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"2026012113123749900_ehf214977-bib-0018","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.cgh.2009.05.033","article-title":"Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease","volume":"7","author":"Shah","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026012113123749900_ehf214977-bib-0019","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.atherosclerosis.2020.03.010","article-title":"Association between liver fibrosis scores and the risk of mortality among patients with coronary artery disease","volume":"299","author":"Chen","year":"2020","journal-title":"Atherosclerosis"},{"key":"2026012113123749900_ehf214977-bib-0020","doi-asserted-by":"publisher","first-page":"3418","DOI":"10.1002\/ehf2.14073","article-title":"Blood-based biomarkers for the prediction of hypertrophic cardiomyopathy prognosis: a systematic review and meta-analysis","volume":"9","author":"Jansen","year":"2022","journal-title":"ESC Heart Failure"},{"key":"2026012113123749900_ehf214977-bib-0021","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1016\/j.jtcvs.2021.04.001","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: A report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"162","author":"Ommen","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026012113123749900_ehf214977-bib-0022","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1093\/eurheartj\/eht070","article-title":"Relation between serum N-terminal pro-brain natriuretic peptide and prognosis in patients with hypertrophic cardiomyopathy","volume":"34","author":"Coats","year":"2013","journal-title":"Eur Heart J"},{"key":"2026012113123749900_ehf214977-bib-0023","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.cjca.2015.02.018","article-title":"Plasma uric acid as a prognostic marker in patients with hypertrophic cardiomyopathy","volume":"31","author":"Zhu","year":"2015","journal-title":"Can J Cardiol"},{"key":"2026012113123749900_ehf214977-bib-0024","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.116.004529","article-title":"Prognostic significance of plasma high-sensitivity C-reactive protein in patients with hypertrophic cardiomyopathy","volume":"6","author":"Zhu","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2026012113123749900_ehf214977-bib-0025","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.jacc.2013.03.055","article-title":"Significance of high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy","volume":"62","author":"Kubo","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026012113123749900_ehf214977-bib-0026","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1055\/s-0031-1284434","article-title":"Liver abnormalities in cardiac diseases and heart failure","volume":"20","author":"Alvarez","year":"2011","journal-title":"Int J Angiol"},{"key":"2026012113123749900_ehf214977-bib-0027","doi-asserted-by":"publisher","first-page":"336","DOI":"10.4070\/kcj.2014.44.5.336","article-title":"Bilirubin level is associated with left ventricular hypertrophy independent of blood pressure in previously untreated hypertensive patients","volume":"44","author":"Ayaz","year":"2014","journal-title":"Korean Circ J"},{"key":"2026012113123749900_ehf214977-bib-0028","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ahj.2010.05.022","article-title":"Serum albumin concentration and heart failure risk the health, aging, and body composition study","volume":"160","author":"Gopal","year":"2010","journal-title":"Am Heart J"},{"key":"2026012113123749900_ehf214977-bib-0029","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020584","article-title":"Impact of the fibrosis-4 index on risk stratification of cardiovascular events and mortality in patients with atrial fibrillation: Findings from a Japanese multicenter registry","volume":"9","author":"Saito","year":"2020","journal-title":"J Clin Med"},{"key":"2026012113123749900_ehf214977-bib-0030","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1002\/ehf2.13317","article-title":"Fibrosis-4 index reflects right ventricular function and prognosis in heart failure with preserved ejection fraction","volume":"8","author":"Nakashima","year":"2021","journal-title":"ESC Heart Failure"},{"key":"2026012113123749900_ehf214977-bib-0031","doi-asserted-by":"publisher","first-page":"453","DOI":"10.14309\/ajg.0000000000001606","article-title":"Fibrosis-4 index can independently predict major adverse cardiovascular events in nonalcoholic fatty liver disease","volume":"117","author":"Vieira Barbosa","year":"2022","journal-title":"Am J Gastroenterol"},{"key":"2026012113123749900_ehf214977-bib-0032","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00392-023-02330-0","article-title":"Liver fibrosis and outcomes of atrial fibrillation: The FIB-4 index","volume":"113","author":"Raposeiras-Roub\u00edn","year":"2023","journal-title":"Clin Res Cardiol"},{"key":"2026012113123749900_ehf214977-bib-0033","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s12072-021-10167-w","article-title":"Liver fibrosis scores and coronary atherosclerosis: Novel findings in patients with stable coronary artery disease","volume":"15","author":"Jin","year":"2021","journal-title":"Hepatol Int"},{"key":"2026012113123749900_ehf214977-bib-0034","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030567","article-title":"Relationship between heart disease and liver disease: A two-way street","volume":"9","author":"El Hadi","year":"2020","journal-title":"Cells"},{"key":"2026012113123749900_ehf214977-bib-0035","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.1093\/eurheartj\/ehx527","article-title":"Women with hypertrophic cardiomyopathy have worse survival","volume":"38","author":"Geske","year":"2017","journal-title":"Eur Heart J"},{"key":"2026012113123749900_ehf214977-bib-0036","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1161\/circulationaha.115.015085","article-title":"Management of atrial fibrillation in hypertrophic cardiomyopathy","volume":"133","author":"MacIntyre","year":"2016","journal-title":"Circulation"},{"key":"2026012113123749900_ehf214977-bib-0037","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1161\/circulationaha.117.029267","article-title":"Clinical profile and consequences of atrial fibrillation in hypertrophic cardiomyopathy","volume":"136","author":"Rowin","year":"2017","journal-title":"Circulation"},{"key":"2026012113123749900_ehf214977-bib-0038","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1136\/heartjnl-2020-317701","article-title":"N-terminal pro-brain natriuretic peptide and sudden cardiac death in hypertrophic cardiomyopathy","volume":"107","author":"Wu","year":"2021","journal-title":"Heart (British Cardiac Society)"},{"key":"2026012113123749900_ehf214977-bib-0039","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.hrthm.2018.04.030","article-title":"B-type natriuretic peptide and risk of sudden death in patients with hypertrophic cardiomyopathy","volume":"15","author":"Minami","year":"2018","journal-title":"Heart Rhythm"},{"key":"2026012113123749900_ehf214977-bib-0040","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1161\/circulationaha.105.583500","article-title":"Prevalence, clinical profile, and significance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy","volume":"114","author":"Harris","year":"2006","journal-title":"Circulation"},{"key":"2026012113123749900_ehf214977-bib-0041","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1016\/j.jacc.2020.04.045","article-title":"Outcomes in patients with hypertrophic cardiomyopathy and left ventricular systolic dysfunction","volume":"75","author":"Rowin","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026012113123749900_ehf214977-bib-0042","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1253\/circj.CJ-22-0109","article-title":"The fibrosis-4 index predicts cardiovascular prognosis in patients with severe isolated tricuspid regurgitation","volume":"86","author":"Nakashima","year":"2022","journal-title":"Circ J"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/11\/6\/3934\/64516909\/eschf_11_6_3934.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/11\/6\/3934\/64516909\/eschf_11_6_3934.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:14:42Z","timestamp":1769019282000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/11\/6\/3934\/8269402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,24]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,7,24]]},"published-print":{"date-parts":[[2024,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.14977","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,7,24]]},"assertion":[{"value":"2024-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}