{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:51:32Z","timestamp":1789105892609,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":385,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Wild-type transthyretin cardiac amyloidosis (ATTRwt CA) is a common, underdiagnosed cause of heart failure (HF) in the elderly. Concurrent extracardiac amyloid infiltration might be responsible for a specific frailty phenotype. This study aims to compare the prevalence and characteristics of frailty parameters in HF patients, with or without ATTRwt CA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a comparative cross-sectional study, we prospectively included consecutive HF patients with or without ATTRwt CA (the HF + ATTRwt+ and HF + ATTRwt\u2212 groups, respectively) between April 2018 and April 2021. Logistic regression models were used to compare the groups with regard to frailty as assessed using multidimensional geriatric tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 123 patients (68 HF + ATTRwt+ and 55 HF + ATTRwt\u2212). The mean age was 80.9 (standard deviation 6.3) years, 87% were male, 34% had left ventricular systolic dysfunction and 34% were New York Heart Association (NYHA) III. Relative to the HF + ATTRwt\u2212 group, patients in the HF + ATTRwt+ group were more likely to have shrinking [odds ratios = 2.9 (95% confidence interval, 1.1 to 1.7), P = 0.03], balance disorders [1.8 (1.1 to 2.8), P = 0.02], memory complaints [2.5, (1.0 to 5.9), P = 0.05] and overactive bladder [1.5 (1.1 to 2.2), P = 0.03], independently of age, sex, NYHA class and diabetes status. The proportion of very frail patients was higher (albeit not significantly) in the HF + ATTRwt+ group than in the HF + ATTRwt\u2212 group [2.4 (0.9 to 6.9), P = 0.10].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ATTRwt CA is associated with a specific frailty phenotype. Patients with ATTRwt CA should be screened for frailty and managed collaboratively by cardiologists and geriatricians, with a view to improving quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15026","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T13:40:51Z","timestamp":1726580451000},"page":"281-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Frailty in Heart Failure According to the Presence or Absence of Wild-Type Transthyretin Cardiac Amyloidosis"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-9864","authenticated-orcid":false,"given":"Amaury","family":"Broussier","sequence":"first","affiliation":[{"name":"INSERM, IMRB, Univ Paris Est Creteil , Creteil ,","place":["France"]},{"name":"Department of Geriatrics, AP-HP, Hopitaux Universitaires Henri-Mondor , Limeil-Brevannes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Paugam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics, AP-HP, Hopitaux Universitaires Henri-Mondor , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, AP-HP, Hopitaux Universitaires Henri-Mondor , Limeil-Brevannes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Oghina","sequence":"additional","affiliation":[{"name":"INSERM, IMRB, Univ Paris Est Creteil , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Heart Failure and Amyloidosis Unit, AP-HP, Hopitaux Universitaires Henri-Mondor , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounira","family":"Kharoubi","sequence":"additional","affiliation":[{"name":"INSERM, IMRB, Univ Paris Est Creteil , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Heart Failure and Amyloidosis Unit, AP-HP, Hopitaux Universitaires Henri-Mondor , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Lafont","sequence":"additional","affiliation":[{"name":"INSERM, IMRB, Univ Paris Est Creteil , Creteil ,","place":["France"]},{"name":"Department of Public Health, AP-HP, Hopitaux Universitaires Henri-Mondor , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Zaroui","sequence":"additional","affiliation":[{"name":"INSERM, IMRB, Univ Paris Est Creteil , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Heart Failure and Amyloidosis Unit, AP-HP, Hopitaux Universitaires Henri-Mondor , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnault","family":"Galat","sequence":"additional","affiliation":[{"name":"INSERM, IMRB, Univ Paris Est Creteil , Creteil ,","place":["France"]},{"name":"Department of Cardiology, Heart Failure and Amyloidosis Unit, AP-HP, Hopitaux Universitaires Henri-Mondor , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Hittinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Failure and Amyloidosis Unit, AP-HP, Hopitaux Universitaires Henri-Mondor , Creteil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Teiger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Failure and Amyloidosis Unit, AP-HP, Hopitaux Universitaires Henri-Mondor , Creteil 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