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This study aimed to screen and investigate the characteristics and prognosis of early-stage HFpEF in the elderly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1789 community-dwelling individuals aged over 65 from northern Shanghai were enrolled. According to American Heart Association (AHA) guidelines, participants were classified into four groups: HFpEF stage 0, HFpEF stage A, HFpEF stage B and HFpEF stage C. Major endpoints included major adverse cardiovascular events (MACEs), all-cause death and cardiovascular death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After a mean follow-up period of 7.10 \u00b1 1.27 years, 1623 elderly subjects were included [HFpEF stage 0 (10.3%), HFpEF stage A (16.3%), HFpEF stage B (60.6%) and HFpEF stage C (12.8%)]. Patients with HFpEF stage A, HFpEF stage B and HFpEF stage C exhibited more MACEs than those in HFpEF stage 0 (P &amp;lt; 0.01). Patients with HFpEF stage C had a significantly higher cardiovascular (P &amp;lt; 0.001) and all-cause death ratio (P &amp;lt; 0.01). With HFpEF stage 0 as a reference, the increases in MACEs were significantly associated with HFpEF stage A [hazard ratio (HR): 2.97, 95% confidence interval (CI) (1.13, 7.82), P &amp;lt; 0.05], HFpEF stage B [HR: 2.69, 95% CI (1.09, 6.64), P &amp;lt; 0.05] and HFpEF stage C [HR: 4.86, 95% CI (1.88, 12.59), P &amp;lt; 0.01] in the Cox regression analysis. Our finding remains unaltered in the sensitivity analysis, with no interaction for effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with those with HFpEF stage 0, patients with HFpEF, whether in stage B or C, exhibit significantly higher cardiovascular and all-cause mortality in the elderly. This study underscores the importance of early-stage HFpEF screening, particularly in older, asymptomatic stage B individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15060","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:40:13Z","timestamp":1726188013000},"page":"229-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognosis of Early-Stage HFpEF in the Community-Dwelling Elderly: The Northern Shanghai Study"],"prefix":"10.1093","volume":"12","author":[{"given":"Weilun","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth 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