{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:10:53Z","timestamp":1787238653932,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":391,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>One treatment option for refractory ventricular arrythmias is stellate ganglion block (SGB). We examined differences in SGB success by patient and arrhythmia characteristics and predictors of successful SGB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This was a multicenter analysis of patients treated for refractory ventricular arrythmias in the Czech Republic and the United States. The primary outcome was absence of ventricular arrythmias at 24 h post SGB. SGB effectiveness was examined according to aetiology of cardiomyopathy, arrhythmia type, laterality of SGB, presence of inotropes, and presence of mechanical circulatory support. Binary logistic regression was used to examine variables associated with the primary outcome. In total there were 117 patients with refractory ventricular arrythmias treated with SGB. Overall, the mean age was 63.5 \u00b1 11.0 years, majority of patients were male (94.0%), White (87.2%), and had an implantable cardioverter defibrillator in situ (70.1%). There were no differences in efficacy of SGB based on aetiology of cardiomyopathy (P = 0.623), arrhythmia type (0.852), laterality of block (P = 0.131), and presence of inotropes (P = 0.083). Multivariable analysis demonstrated that increased age was associated with decreased odds of SGB success (odds ratio: 0.96, confidence interval: 0.92\u20130.99, P = 0.039) whereas increased left ventricular ejection fraction trended towards increased odds of SGB success (odds ratio: 1.05, confidence interval: 0.995\u20131.11, P = 0.077).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this multicentre experience, SGB was similarly effective despite the aetiology of cardiomyopathy, type of arrhythmia, laterality, and inotropic or mechanical support. SGB was less effective for the suppression of ventricular arrythmias at 24 h for the elderly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15072","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T05:44:12Z","timestamp":1725947052000},"page":"110-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Factors Associated with Stellate Ganglion Block Success in Recurrent Ventricular Arrhythmias"],"prefix":"10.1093","volume":"12","author":[{"given":"Fouad","family":"Chouairi","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Duke University School of Medicine , Durham, North Carolina ,","place":["USA"]},{"name":"Duke Clinical Research Institute , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ales","family":"Benak","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine , Prague ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Piccini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Duke University School of Medicine , Durham, North Carolina ,","place":["USA"]},{"name":"Duke Clinical Research Institute , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Toman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Duke University School of Medicine , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Duke University School of Medicine , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Duke University School of Medicine , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Sramko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Duke University School of Medicine , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"2026012113060390100_ehf215072-bib-0001","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.autneu.2017.03.005","article-title":"The role of the autonomic nervous system in arrhythmias and sudden cardiac death","volume":"205","author":"Franciosi","year":"2017","journal-title":"Auton Neurosci"},{"key":"2026012113060390100_ehf215072-bib-0002","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/jce.13152","article-title":"Autonomic modulation for the treatment of ventricular arrhythmias: therapeutic use of percutaneous stellate ganglion blocks","volume":"28","author":"Fudim","year":"2017","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2026012113060390100_ehf215072-bib-0003","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.hrthm.2018.02.015","article-title":"Mechanisms and management of refractory ventricular arrhythmias in the age of autonomic modulation","volume":"15","author":"Bradfield","year":"2018","journal-title":"Heart Rhythm"},{"key":"2026012113060390100_ehf215072-bib-0004","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.jacep.2023.12.012","article-title":"A multicenter study of stellate ganglion block as a temporizing treatment for refractory ventricular arrhythmias","volume":"10","author":"Chouairi","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"2026012113060390100_ehf215072-bib-0005","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.jacep.2019.12.017","article-title":"Stellate ganglion blockade for the treatment of refractory ventricular arrhythmias","volume":"6","author":"Fudim","year":"2020","journal-title":"JACC Clin Electrophysiol"},{"key":"2026012113060390100_ehf215072-bib-0006","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s11906-020-01111-8","article-title":"Stellate ganglion blockade: an intervention for the management of ventricular arrhythmias","volume":"22","author":"Ganesh","year":"2020","journal-title":"Curr Hypertens Rep"},{"key":"2026012113060390100_ehf215072-bib-0007","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.987008","article-title":"Mechanical circulatory support in ventricular arrhythmias","volume":"9","author":"Tavazzi","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2026012113060390100_ehf215072-bib-0008","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.hrthm.2021.03.047","article-title":"Electrical storm in patients with left ventricular assist devices: risk factors, incidence, and impact on survival","volume":"18","author":"Rehorn","year":"2021","journal-title":"Heart Rhythm"},{"key":"2026012113060390100_ehf215072-bib-0009","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.cardfail.2004.08.158","article-title":"Prolonged repolarization after ventricular assist device support is associated with arrhythmias in humans with congestive heart failure","volume":"11","author":"Harding","year":"2005","journal-title":"J Card Fail"},{"key":"2026012113060390100_ehf215072-bib-0010","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.ijcard.2015.07.065","article-title":"Impella ventricular support in clinical practice: collaborative viewpoint from a European expert user group","volume":"201","author":"Burzotta","year":"2015","journal-title":"Int J Cardiol"},{"key":"2026012113060390100_ehf215072-bib-0011","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1007\/s00259-016-3432-3","article-title":"Impact of aging on cardiac sympathetic innervation measured by (123)I-mIBG imaging in patients with systolic heart failure","volume":"43","author":"Rengo","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2026012113060390100_ehf215072-bib-0012","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.biocel.2019.01.004","article-title":"Sympathetic nervous system in age-related cardiovascular dysfunction: pathophysiology and therapeutic perspective","volume":"108","author":"de Lucia","year":"2019","journal-title":"Int J Biochem Cell Biol"},{"key":"2026012113060390100_ehf215072-bib-0013","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s00391-022-02131-6","article-title":"Impact of age on the prognosis of patients with ventricular tachyarrhythmias and aborted cardiac arrest","volume":"56","author":"Weidner","year":"2023","journal-title":"Z Gerontol Geriatr"},{"key":"2026012113060390100_ehf215072-bib-0014","doi-asserted-by":"publisher","first-page":"289","DOI":"10.4065\/84.3.289","article-title":"Ventricular tachycardia and sudden cardiac death","volume":"84","author":"Koplan","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"2026012113060390100_ehf215072-bib-0015","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd8050057","article-title":"Sympathetic activation and arrhythmogenesis after myocardial infarction: where do we stand?","volume":"8","author":"Zekios","year":"2021","journal-title":"J Cardiovasc Dev Dis"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/1\/110\/64512779\/eschf_12_1_110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/1\/110\/64512779\/eschf_12_1_110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:06:10Z","timestamp":1769018770000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/12\/1\/110\/8261799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,9,10]]},"published-print":{"date-parts":[[2025,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.15072","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2024,9,10]]},"assertion":[{"value":"2024-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}