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This study aims to determine whether low muscle mass affects the alterations in myocardial substrate metabolism that are associated with the development of cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The study included 299 individuals (182 men and 117 women) who underwent examination at the Severance Health Check-up Center between January 2018 and February 2019. Myocardial glucose uptake was assessed using [18F]-fluorodeoxyglucose-positron emission tomography (18F-FDG PET\/CT) scanning. Direct segmental bioimpedance analysis was used to measure appendicular skeletal muscle mass (ASM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analysed men and women separately owing to sex-related body composition differences. ASM\/Ht2 was significantly positively correlated with myocardial glucose uptake measured by 18F-FDG PET\/CT [ln (SUVheart\/liver)] only in men (r = 0.154, P = 0.038 in men; r = \u22120.042, P = 0.652 in women, respectively). In men, myocardial glucose uptake was significantly associated with ASM\/Ht2 even after adjusting for multiple confounders in a multivariable linear regression model (standardized \u03b2 = 0.397, P = 0.004, in men; \u03b2 = \u2212 0.051, P = 0.698, in women). In women, age (\u03b2 = \u22120.424 P = 0.029) was independent determinants of myocardial glucose uptake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In men, ASM was strongly associated with myocardial glucose uptake as measured by 18F-FDG PET\/CT. In women, age was significantly correlated with myocardial substrate utilization, but not with ASM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15086","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:58:07Z","timestamp":1727679487000},"page":"467-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Appendicular Skeletal Muscle Mass and Myocardial Glucose Uptake Measured by 18F-FDG PET"],"prefix":"10.1093","volume":"12","author":[{"given":"Young-eun","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine , Seoul ,","place":["Republic of Korea"]},{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine , Seoul 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