{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:30:12Z","timestamp":1793039412495,"version":"4.5.0"},"reference-count":140,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":500,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF). In addition, right HF (RHF) is a common complication associated with various diseases, including congenital heart disease, myocardial infarction (MI), pulmonary arterial hypertension (PAH) and dilated cardiomyopathy (DCM), and it can manifest at any time after left ventricular assist devices (LVADs). The sodium\u2013glucose cotransporter 2 (SGLT2) inhibition by gliflozins has emerged as a cornerstone medicine for managing type 2 diabetes mellitus (T2DM) and HF, with an increasing focus on its potential to enhance RV function. In this review, we aim to present an updated perspective on the pleiotropic effects of gliflozins on the right ventricle and offer insights into the underlying mechanisms. We can ascertain their advantageous impact on the right ventricle by discussing the evidence obtained in animal models and monumental clinical trials. In light of the pathophysiological changes in RHF, we attempt to elucidate crucial mechanisms regarding their beneficial effects, including alleviation of RV overload, reduction of hyperinsulinaemia and inflammatory responses, regulation of nutrient signalling pathways and cellular energy metabolism, inhibition of oxidative stress and myocardial fibrosis, and maintenance of ion balance. Finally, this drug class's potential application and benefits in various clinical settings are described, along with a prospective outlook on future clinical practice and research directions.<\/jats:p>","DOI":"10.1002\/ehf2.15103","type":"journal-article","created":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T21:43:26Z","timestamp":1728251006000},"page":"1045-1058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Effects of Sodium\u2013Glucose Cotransporter 2 Inhibitors on the \u2018Forgotten\u2019 Right Ventricle"],"prefix":"10.1093","volume":"12","author":[{"given":"Liangzhen","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine , Yiwu ,","place":["China"]},{"name":"International School of Medicine, International Institutes of Medicine, Zhejiang University , Yiwu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine , Yiwu ,","place":["China"]},{"name":"International School of Medicine, International Institutes of Medicine, Zhejiang University , Yiwu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,6]]},"reference":[{"key":"2026021803542420300_ehf215103-bib-0001","doi-asserted-by":"publisher","first-page":"e895","DOI":"10.1161\/CIR.0000000000001063","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"2026021803542420300_ehf215103-bib-0002","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027852","article-title":"Burden, trends, and inequalities of heart failure globally, 1990 to 2019: a secondary analysis based on the Global Burden of Disease 2019 study","volume":"12","author":"Yan","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"2026021803542420300_ehf215103-bib-0003","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.jacc.2023.05.010","article-title":"Right ventricular function and pulmonary coupling in patients with heart failure and preserved ejection fraction","volume":"82","author":"Inciardi","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0004","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1161\/CIRCULATIONAHA.109.887570","article-title":"Effects of right ventricular ejection fraction on outcomes in chronic systolic heart failure","volume":"121","author":"Meyer","year":"2010","journal-title":"Circulation"},{"key":"2026021803542420300_ehf215103-bib-0005","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1002\/ejhf.873","article-title":"Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction","volume":"19","author":"Bosch","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"2026021803542420300_ehf215103-bib-0006","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1093\/ehjci\/jead145","article-title":"Right ventricular to pulmonary artery coupling and outcome in patients with cardiac amyloidosis","volume":"24","author":"Tomasoni","year":"2023","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026021803542420300_ehf215103-bib-0007","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.hjc.2023.06.002","article-title":"Right ventricular\u2013pulmonary arterial coupling in patients with implanted left ventricular assist devices","volume":"77","author":"St\u0105p\u00f3r","year":"2024","journal-title":"Hellenic J Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0008","doi-asserted-by":"publisher","first-page":"e578","DOI":"10.1161\/CIR.0000000000000560","article-title":"Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association","volume":"137","author":"Konstam","year":"2018","journal-title":"Circulation"},{"key":"2026021803542420300_ehf215103-bib-0009","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.healun.2013.10.015","article-title":"Right heart failure: toward a common language","volume":"33","author":"Mehra","year":"2014","journal-title":"J Heart Lung Transplant"},{"key":"2026021803542420300_ehf215103-bib-0010","doi-asserted-by":"publisher","first-page":"111","DOI":"10.4250\/jcvi.2018.26.e11","article-title":"Strain analysis of the right ventricle using two-dimensional echocardiography","volume":"26","author":"Lee","year":"2018","journal-title":"J Cardiovasc Imaging"},{"key":"2026021803542420300_ehf215103-bib-0011","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s10741-019-09778-1","article-title":"Right ventricular mechanical pattern in health and disease: beyond longitudinal shortening","volume":"24","author":"Kov\u00e1cs","year":"2019","journal-title":"Heart Fail Rev"},{"key":"2026021803542420300_ehf215103-bib-0012","doi-asserted-by":"publisher","first-page":"806","DOI":"10.3390\/diagnostics12040806","article-title":"Three-dimensional echocardiography assessment of right ventricular volumes and function: technological perspective and clinical application","volume":"12","author":"Ahmad","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"2026021803542420300_ehf215103-bib-0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2021.106839","article-title":"Exploring the mechanisms of action of gliflozines in heart failure and possible implications in pulmonary hypertension","volume":"138","author":"Madonna","year":"2021","journal-title":"Vascul Pharmacol"},{"key":"2026021803542420300_ehf215103-bib-0014","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1177\/1479164114561992","article-title":"Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences","volume":"12","author":"Gallo","year":"2015","journal-title":"Diab Vasc Dis Res"},{"key":"2026021803542420300_ehf215103-bib-0015","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N Engl J Med"},{"key":"2026021803542420300_ehf215103-bib-0016","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1056\/NEJMoa1611925","article-title":"Canagliflozin and cardiovascular and renal events in type 2 diabetes","volume":"377","author":"Neal","year":"2017","journal-title":"N Engl J Med"},{"key":"2026021803542420300_ehf215103-bib-0017","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1056\/NEJMoa1811744","article-title":"Canagliflozin and renal outcomes in type 2 diabetes and nephropathy","volume":"380","author":"Perkovic","year":"2019","journal-title":"N Engl J Med"},{"key":"2026021803542420300_ehf215103-bib-0018","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1056\/NEJMoa1812389","article-title":"Dapagliflozin and cardiovascular outcomes in type 2 diabetes","volume":"380","author":"Wiviott","year":"2019","journal-title":"N Engl J Med"},{"key":"2026021803542420300_ehf215103-bib-0019","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","article-title":"Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes","volume":"373","author":"Zinman","year":"2015","journal-title":"N Engl J Med"},{"key":"2026021803542420300_ehf215103-bib-0020","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(18)32590-X","article-title":"SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials","volume":"393","author":"Zelniker","year":"2019","journal-title":"Lancet"},{"key":"2026021803542420300_ehf215103-bib-0021","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.cmet.2019.10.008","article-title":"The DAPA-HF trial: a momentous victory in the war against heart failure","volume":"30","author":"Bhatt","year":"2019","journal-title":"Cell Metab"},{"key":"2026021803542420300_ehf215103-bib-0022","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.jacbts.2020.02.004","article-title":"Mechanisms of cardiovascular benefits of sodium glucose co-transporter 2 (SGLT2) inhibitors: a state-of-the-art review","volume":"5","author":"Lopaschuk","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"2026021803542420300_ehf215103-bib-0023","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1007\/s40265-022-01778-0","article-title":"Empagliflozin: a review in symptomatic chronic heart failure","volume":"82","author":"Je","year":"2022","journal-title":"Drugs"},{"key":"2026021803542420300_ehf215103-bib-0024","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.echo.2014.11.017","article-title":"Right heart mechanics in untreated normotensive patients with prediabetes and type 2 diabetes mellitus: a two- and three-dimensional echocardiographic study","volume":"28","author":"Tadic","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"2026021803542420300_ehf215103-bib-0025","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1007\/s00330-017-5185-1","article-title":"Subclinical changes in MRI-determined right ventricular volumes and function in subjects with prediabetes and diabetes","volume":"28","author":"Patscheider","year":"2018","journal-title":"Eur Radiol"},{"key":"2026021803542420300_ehf215103-bib-0026","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.amjcard.2017.11.040","article-title":"Diabetes mellitus and right ventricular dysfunction in heart failure with preserved ejection fraction","volume":"121","author":"Gorter","year":"2018","journal-title":"Am J Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0027","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1002\/ehf2.13871","article-title":"The first experience with sodium-glucose cotransporter 2 inhibitor for the treatment of systemic right ventricular failure","volume":"9","author":"Egorova","year":"2022","journal-title":"ESC Heart Fail."},{"key":"2026021803542420300_ehf215103-bib-0028","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ijcard.2022.08.008","article-title":"The prognostic value of right ventricular ejection fraction by cardiovascular magnetic resonance in heart failure: a systematic review and meta-analysis","volume":"368","author":"Papanastasiou","year":"2022","journal-title":"Int J Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0029","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s11897-023-00601-5","article-title":"Management of acute right ventricular failure","volume":"20","author":"Asakage","year":"2023","journal-title":"Curr Heart Fail Rep"},{"key":"2026021803542420300_ehf215103-bib-0030","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1001\/jama.2022.4402","article-title":"Diagnosis and treatment of pulmonary arterial hypertension: a review","volume":"327","author":"Ruopp","year":"2022","journal-title":"JAMA"},{"key":"2026021803542420300_ehf215103-bib-0031","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: the Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"key":"2026021803542420300_ehf215103-bib-0032","doi-asserted-by":"publisher","first-page":"H1167","DOI":"10.1152\/ajpheart.00319.2018","article-title":"Pulmonary vascular mechanical consequences of ischemic heart failure and implications for right ventricular function","volume":"316","author":"Philip","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026021803542420300_ehf215103-bib-0033","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1161\/CIRCRESAHA.122.319967","article-title":"Understanding the pathobiology of pulmonary hypertension due to left heart disease","volume":"130","author":"Huston","year":"2022","journal-title":"Circ Res"},{"key":"2026021803542420300_ehf215103-bib-0034","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s13105-020-00742-4","article-title":"AMPK\u03b12 deficiency exacerbates hypoxia-induced pulmonary hypertension by promoting pulmonary arterial smooth muscle cell proliferation","volume":"76","author":"Wang","year":"2020","journal-title":"J Physiol Biochem"},{"key":"2026021803542420300_ehf215103-bib-0035","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s10741-019-09902-1","article-title":"Mechanisms for heart failure in systemic right ventricle","volume":"25","author":"Andrade","year":"2020","journal-title":"Heart Fail Rev"},{"key":"2026021803542420300_ehf215103-bib-0036","doi-asserted-by":"publisher","first-page":"i2","DOI":"10.1136\/hrt.2005.077875","article-title":"Anatomy, echocardiography, and normal right ventricular dimensions","volume":"92","author":"Ho","year":"2006","journal-title":"Heart"},{"key":"2026021803542420300_ehf215103-bib-0037","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.hfc.2018.12.015","article-title":"Right ventricular size and function in chronic heart failure: not to be forgotten","volume":"15","author":"Zhou","year":"2019","journal-title":"Heart Fail Clin"},{"key":"2026021803542420300_ehf215103-bib-0038","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1161\/CIRCULATIONAHA.114.012975","article-title":"Molecular mechanisms of right ventricular failure","volume":"132","author":"Reddy","year":"2015","journal-title":"Circulation"},{"key":"2026021803542420300_ehf215103-bib-0039","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.ccl.2020.01.009","article-title":"Pathophysiology of acute and chronic right heart failure","volume":"38","author":"Thandavarayan","year":"2020","journal-title":"Cardiol Clin"},{"key":"2026021803542420300_ehf215103-bib-0040","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1161\/CIRCULATIONAHA.122.061732","article-title":"Critical reanalysis of the mechanisms underlying the cardiorenal benefits of SGLT2 inhibitors and reaffirmation of the nutrient deprivation signaling\/autophagy hypothesis","volume":"146","author":"Packer","year":"2022","journal-title":"Circulation"},{"key":"2026021803542420300_ehf215103-bib-0041","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/s41569-022-00824-4","article-title":"SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism","volume":"20","author":"Packer","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0042","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1165\/rcmb.2016-0364OC","article-title":"Pharmacological inhibition of mTOR kinase reverses right ventricle remodeling and improves right ventricle structure and function in rats","volume":"57","author":"Pena","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026021803542420300_ehf215103-bib-0043","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1097\/HJH.0000000000001676","article-title":"Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension","volume":"36","author":"Zurlo","year":"2018","journal-title":"J Hypertens"},{"key":"2026021803542420300_ehf215103-bib-0044","doi-asserted-by":"publisher","first-page":"L208","DOI":"10.1152\/ajplung.00242.2014","article-title":"Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension","volume":"308","author":"Tang","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021803542420300_ehf215103-bib-0045","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3390\/kidneydial3010005","article-title":"Renal mechanisms of diuretic resistance in congestive heart failure","volume":"3","author":"Lameire","year":"2023","journal-title":"Kidney and Dialysis"},{"key":"2026021803542420300_ehf215103-bib-0046","doi-asserted-by":"publisher","first-page":"H113","DOI":"10.1152\/ajpheart.00440.2018","article-title":"Right ventricular dysfunction and remodeling in diabetic cardiomyopathy","volume":"316","author":"Kang","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026021803542420300_ehf215103-bib-0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112169","article-title":"Effects of SGLT2 inhibitors on ion homeostasis and oxidative stress associated mechanisms in heart failure","volume":"143","author":"Gager","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"2026021803542420300_ehf215103-bib-0048","doi-asserted-by":"publisher","first-page":"301","DOI":"10.21037\/atm.2018.06.04","article-title":"Neurohormonal modulation as therapeutic avenue for right ventricular dysfunction in pulmonary artery hypertension: till the dawn, waiting","volume":"6","author":"Emanuel","year":"2018","journal-title":"Ann Transl Med"},{"key":"2026021803542420300_ehf215103-bib-0049","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1161\/CIRCRESAHA.117.309345","article-title":"Arrhythmogenic cardiomyopathy","volume":"121","author":"Corrado","year":"2017","journal-title":"Circ Res"},{"key":"2026021803542420300_ehf215103-bib-0050","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1161\/CIRCRESAHA.116.309396","article-title":"Dilated cardiomyopathy: genetic determinants and mechanisms","volume":"121","author":"McNally","year":"2017","journal-title":"Circ Res"},{"key":"2026021803542420300_ehf215103-bib-0051","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1067\/mhj.2001.116071","article-title":"Reduced right ventricular ejection fraction as a marker for idiopathic dilated cardiomyopathy compared with ischemic left ventricular dysfunction","volume":"142","author":"La Vecchia","year":"2001","journal-title":"Am Heart J"},{"key":"2026021803542420300_ehf215103-bib-0052","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1016\/j.cjca.2021.06.024","article-title":"Prevalence and evolution of right ventricular dysfunction among different genetic backgrounds in dilated cardiomyopathy","volume":"37","author":"Manca","year":"2021","journal-title":"Can J Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0053","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.jcmg.2016.01.027","article-title":"The prognostic impact of the evolution of RV function in idiopathic DCM","volume":"9","author":"Merlo","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026021803542420300_ehf215103-bib-0054","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1007\/s10741-022-10229-7","article-title":"The right ventricular involvement in dilated cardiomyopathy: prevalence and prognostic implications of the often-neglected child","volume":"27","author":"Manca","year":"2022","journal-title":"Heart Fail Rev"},{"key":"2026021803542420300_ehf215103-bib-0055","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41586-019-1406-x","article-title":"Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy","volume":"572","author":"Lee","year":"2019","journal-title":"Nature"},{"key":"2026021803542420300_ehf215103-bib-0056","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1001\/jamacardio.2017.2275","article-title":"Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action","volume":"2","author":"Packer","year":"2017","journal-title":"JAMA Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0057","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.230427","article-title":"MYH7 R453C induced cardiac remodelling via activating TGF-\u03b2\/Smad2\/3, ERK1\/2 and Nox4\/ROS\/NF-\u03baB signalling pathways","volume":"14","author":"Wang","year":"2024","journal-title":"Open Biol"},{"key":"2026021803542420300_ehf215103-bib-0058","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.3390\/ijms25063122","article-title":"The role of sodium-glucose co-transporter-2 inhibitors on diuretic resistance in heart failure","volume":"25","author":"Stachteas","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026021803542420300_ehf215103-bib-0059","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12933-017-0654-z","article-title":"SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial","volume":"17","author":"Karg","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"2026021803542420300_ehf215103-bib-0060","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s13300-018-0385-5","article-title":"Empagliflozin induces transient diuresis without changing long-term overall fluid balance in Japanese patients with type 2 diabetes","volume":"9","author":"Yasui","year":"2018","journal-title":"Diabetes Ther"},{"key":"2026021803542420300_ehf215103-bib-0061","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1210\/jc.2011-2260","article-title":"Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin","volume":"97","author":"Bolinder","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2026021803542420300_ehf215103-bib-0062","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1056\/NEJMoa1812389","article-title":"Dapagliflozin and cardiovascular outcomes in type 2 diabetes","volume":"380","author":"Wiviott","year":"2019","journal-title":"N Engl J Med"},{"key":"2026021803542420300_ehf215103-bib-0063","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.kint.2021.09.005","article-title":"A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function","volume":"101","author":"Heerspink","year":"2022","journal-title":"Kidney Int"},{"key":"2026021803542420300_ehf215103-bib-0064","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s41440-022-01085-x","article-title":"Canagliflozin independently reduced plasma volume from conventional diuretics in patients with type 2 diabetes and chronic heart failure: a subanalysis of the CANDLE trial","volume":"46","author":"Shiina","year":"2023","journal-title":"Hypertens Res"},{"key":"2026021803542420300_ehf215103-bib-0065","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1093\/eurheartj\/ehad345","article-title":"SGLT2 inhibitors and diuretics in heart failure: clicking reset on the renal volume setpoint?","volume":"44","author":"Borlaug","year":"2023","journal-title":"Eur Heart J"},{"key":"2026021803542420300_ehf215103-bib-0066","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.amjcard.2006.11.052","article-title":"Prognostic importance of pulmonary hypertension in patients with heart failure","volume":"99","author":"Kjaergaard","year":"2007","journal-title":"Am J Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0067","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.bbrc.2020.01.015","article-title":"The SGLT2 inhibitor empagliflozin reduces mortality and prevents progression in experimental pulmonary hypertension","volume":"524","author":"Chowdhury","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"2026021803542420300_ehf215103-bib-0068","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.821518","article-title":"Dapagliflozin has no protective effect on experimental pulmonary arterial hypertension and pulmonary trunk banding rat models","volume":"12","author":"Li","year":"2021","journal-title":"Front Pharmacol"},{"key":"2026021803542420300_ehf215103-bib-0069","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12890-022-01939-7","article-title":"Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension","volume":"22","author":"Tang","year":"2022","journal-title":"BMC Pulm Med"},{"key":"2026021803542420300_ehf215103-bib-0070","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.jjcc.2022.10.003","article-title":"Tofogliflozin, a sodium-glucose cotransporter 2 inhibitor, improves pulmonary vascular remodeling due to left heart disease in mice","volume":"81","author":"Joki","year":"2023","journal-title":"J Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0071","doi-asserted-by":"crossref","DOI":"10.1080\/10641963.2023.2278205","article-title":"Canagliflozin ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting pulmonary arterial smooth muscle cell proliferation","volume":"45","author":"Tang","year":"2023","journal-title":"Clin Exp Hypertens"},{"key":"2026021803542420300_ehf215103-bib-0072","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006277","article-title":"Empagliflozin blunts worsening cardiac dysfunction associated with reduced NLRP3 (nucleotide-binding domain-like receptor protein 3) inflammasome activation in heart failure","volume":"13","author":"Byrne","year":"2020","journal-title":"Circ Heart Fail"},{"key":"2026021803542420300_ehf215103-bib-0073","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1111\/jcmm.15671","article-title":"Astragaloside IV attenuates inflammatory response mediated by NLRP-3\/calpain-1 is involved in the development of pulmonary hypertension","volume":"25","author":"Sun","year":"2021","journal-title":"J Cell Mol Med"},{"key":"2026021803542420300_ehf215103-bib-0074","doi-asserted-by":"publisher","first-page":"11409","DOI":"10.1111\/jcmm.15745","article-title":"Transcriptomic analysis identifies Toll-like and Nod-like pathways and necroptosis in pulmonary arterial hypertension","volume":"24","author":"Xiao","year":"2020","journal-title":"J Cell Mol Med"},{"key":"2026021803542420300_ehf215103-bib-0075","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1183\/09031936.00151313","article-title":"Proinflammatory cytokine levels are linked to death in pulmonary arterial hypertension","volume":"43","author":"Cracowski","year":"2014","journal-title":"Eur Respir J"},{"key":"2026021803542420300_ehf215103-bib-0076","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1465-9921-12-128","article-title":"Kr\u00fcppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension","volume":"12","author":"Courboulin","year":"2011","journal-title":"Respir Res"},{"key":"2026021803542420300_ehf215103-bib-0077","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1038\/s41467-018-06376-x","article-title":"Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway","volume":"9","author":"Dai","year":"2018","journal-title":"Nat Commun"},{"key":"2026021803542420300_ehf215103-bib-0078","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jacc.2023.10.030","article-title":"Hyperuricemia and gout reduction by SGLT2 inhibitors in diabetes and heart failure: JACC review topic of the week","volume":"83","author":"Packer","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0079","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1111\/dom.14769","article-title":"Mediators of ertugliflozin effects on heart failure and kidney outcomes among patients with type 2 diabetes mellitus","volume":"24","author":"Segar","year":"2022","journal-title":"Diabetes Obes Metab"},{"key":"2026021803542420300_ehf215103-bib-0080","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1183\/09031936.99.13368299","article-title":"Hyperuricaemia in patients with right or left heart failure","volume":"13","author":"Hoeper","year":"1999","journal-title":"Eur Respir J"},{"key":"2026021803542420300_ehf215103-bib-0081","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.805415","article-title":"The prognostic impact of serum uric acid on disease severity and 5-year mortality in patients with idiopathic pulmonary artery hypertension","volume":"9","author":"Yan","year":"2022","journal-title":"Front Med"},{"key":"2026021803542420300_ehf215103-bib-0082","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.clinbiochem.2021.11.004","article-title":"New prognostic markers in pulmonary arterial hypertension: CRP to albumin ratio and uric acid","volume":"100","author":"Cerik","year":"2022","journal-title":"Clin Biochem"},{"key":"2026021803542420300_ehf215103-bib-0083","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1143458","article-title":"Serum uric acid: a risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction","volume":"14","author":"Deng","year":"2023","journal-title":"Front Endocrinol"},{"key":"2026021803542420300_ehf215103-bib-0084","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.636152","article-title":"Mechanisms and perspectives of sodium-glucose co-transporter 2 inhibitors in heart failure","volume":"8","author":"Zeng","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2026021803542420300_ehf215103-bib-0085","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116505","article-title":"Canagliflozin inhibits PASMCs proliferation via regulating SGLT1\/AMPK signaling and attenuates artery remodeling in MCT-induced pulmonary arterial hypertension","volume":"174","author":"Chen","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"2026021803542420300_ehf215103-bib-0086","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12702","article-title":"Role of Rho kinase and Na+\/H+ exchange in hypoxia-induced pulmonary arterial smooth muscle cell proliferation and migration","volume":"4","author":"Walker","year":"2016","journal-title":"Physiol Rep"},{"key":"2026021803542420300_ehf215103-bib-0087","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/j.numecd.2020.05.030","article-title":"Sodium-glucose co-transporter-2 inhibitors: peculiar \u201chybrid\u201d diuretics that protect from target organ damage and cardiovascular events","volume":"30","author":"Sarzani","year":"2020","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2026021803542420300_ehf215103-bib-0088","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.738848","article-title":"Effects of SGLT2 inhibitors and GLP-1 receptor agonists on renin-angiotensin-aldosterone system","volume":"12","author":"Puglisi","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026021803542420300_ehf215103-bib-0089","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.3390\/medicina58081128","article-title":"Effects of sodium-glucose co-transporter-2 inhibition on pulmonary arterial stiffness and right ventricular function in heart failure with reduced ejection fraction","volume":"58","author":"\u00c7amc\u0131","year":"2022","journal-title":"Medicina (Kaunas)"},{"key":"2026021803542420300_ehf215103-bib-0090","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1007\/s00424-014-1619-7","article-title":"Localizations of Na+-d-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart","volume":"467","author":"Vrhovac","year":"2015","journal-title":"Pflugers Arch"},{"key":"2026021803542420300_ehf215103-bib-0091","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ijcard.2017.05.032","article-title":"Sodium-dependent glucose transporters (SGLT) in human ischemic heart: a new potential pharmacological target","volume":"243","author":"Di Franco","year":"2017","journal-title":"Int J Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0092","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1080\/00325481.2019.1581971","article-title":"SGLT2 inhibitors and cardioprotection: a matter of debate and multiple hypotheses","volume":"131","author":"Filippatos","year":"2019","journal-title":"Postgrad Med"},{"key":"2026021803542420300_ehf215103-bib-0093","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12933-022-01614-5","article-title":"Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium handling","volume":"21","author":"Wu","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"2026021803542420300_ehf215103-bib-0094","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","article-title":"Cardiac fibrosis","volume":"117","author":"Frangogiannis","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2026021803542420300_ehf215103-bib-0095","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10557-022-07377-1","article-title":"The SGLT2i dapagliflozin reduces RV mass independent of changes in RV pressure induced by pulmonary artery banding","volume":"38","author":"Connelly","year":"2024","journal-title":"Cardiovasc Drugs Ther"},{"key":"2026021803542420300_ehf215103-bib-0096","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.cmet.2015.01.005","article-title":"Altered myocardial calcium cycling and energetics in heart failure\u2014a rational approach for disease treatment","volume":"21","author":"Gorski","year":"2015","journal-title":"Cell Metab"},{"key":"2026021803542420300_ehf215103-bib-0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.105788","article-title":"Empagliflozin prevents from early cardiac injury post myocardial infarction in non-diabetic mice","volume":"161","author":"Liu","year":"2021","journal-title":"Eur J Pharm Sci"},{"key":"2026021803542420300_ehf215103-bib-0098","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2337\/dc12-0474","article-title":"Right ventricular involvement in diabetic cardiomyopathy","volume":"36","author":"Widya","year":"2013","journal-title":"Diabetes Care"},{"key":"2026021803542420300_ehf215103-bib-0099","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/eurheartj\/ehaa360","article-title":"Longevity genes, cardiac ageing, and the pathogenesis of cardiomyopathy: implications for understanding the effects of current and future treatments for heart failure","volume":"41","author":"Packer","year":"2020","journal-title":"Eur Heart J"},{"key":"2026021803542420300_ehf215103-bib-0100","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1841527","article-title":"Resveratrol prevents right ventricle remodeling and dysfunction in monocrotaline-induced pulmonary arterial hypertension with a limited improvement in the lung vasculature","volume":"2020","author":"V\u00e1zquez-Garza","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"2026021803542420300_ehf215103-bib-0101","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/cells11010066","article-title":"The isoquinoline-sulfonamide compound H-1337 attenuates SU5416\/hypoxia-induced pulmonary arterial hypertension in rats","volume":"11","author":"Shoji","year":"2021","journal-title":"Cells"},{"key":"2026021803542420300_ehf215103-bib-0102","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111395","article-title":"Inhibition of mTOR by rapamycin does not improve hypoxic pulmonary hypertension-induced right heart failure in old mice","volume":"151","author":"McNair","year":"2021","journal-title":"Exp Gerontol"},{"key":"2026021803542420300_ehf215103-bib-0103","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.ihj.2016.06.010","article-title":"Role of cardiac renin angiotensin system in ischemia reperfusion injury and preconditioning of heart","volume":"68","author":"Agrawal","year":"2016","journal-title":"Indian Heart J"},{"key":"2026021803542420300_ehf215103-bib-0104","doi-asserted-by":"crossref","first-page":"vii","DOI":"10.1016\/j.ccl.2013.09.002","article-title":"The renin-angiotensin-aldosterone system and heart failure","volume":"32","author":"Sayer","year":"2014","journal-title":"Cardiol Clin"},{"key":"2026021803542420300_ehf215103-bib-0105","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1681\/ASN.2016050510","article-title":"Dapagliflozin binds specifically to sodium-glucose cotransporter 2 in the proximal renal tubule","volume":"28","author":"Ghezzi","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"2026021803542420300_ehf215103-bib-0106","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/S2213-8587(15)00424-6","article-title":"Understanding EMPA-REG OUTCOME","volume":"3","author":"Muskiet","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2026021803542420300_ehf215103-bib-0107","doi-asserted-by":"publisher","first-page":"H1007","DOI":"10.1152\/ajpheart.00563.2014","article-title":"Angiotensin-(1\u20137) treatment mitigates right ventricular fibrosis as a distinctive feature of diabetic cardiomyopathy","volume":"308","author":"Hao","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026021803542420300_ehf215103-bib-0108","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12933-021-01390-8","article-title":"Impact of empagliflozin on right ventricular parameters and function among patients with type 2 diabetes","volume":"20","author":"Sarak","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"2026021803542420300_ehf215103-bib-0109","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ijcard.2016.09.068","article-title":"Genetic basis of dilated cardiomyopathy","volume":"224","author":"P\u00e9rez-Serra","year":"2016","journal-title":"Int J Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0110","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1111\/jcmm.12926","article-title":"The expression of Lamin A mutant R321X leads to endoplasmic reticulum stress with aberrant Ca2+ handling","volume":"20","author":"Carmosino","year":"2016","journal-title":"J Cell Mol Med"},{"key":"2026021803542420300_ehf215103-bib-0111","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.pcad.2012.06.002","article-title":"Arrhythmias in pulmonary arterial hypertension","volume":"55","author":"Rajdev","year":"2012","journal-title":"Prog Cardiovasc Dis"},{"key":"2026021803542420300_ehf215103-bib-0112","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.hrthm.2022.02.003","article-title":"Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension","volume":"19","author":"Tanaka","year":"2022","journal-title":"Heart Rhythm"},{"key":"2026021803542420300_ehf215103-bib-0113","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s12967-023-04170-y","article-title":"Targeting unfolded protein response reverts ER stress and ER Ca2+ homeostasis in cardiomyocytes expressing the pathogenic variant of Lamin A\/C R321X","volume":"21","author":"Pietrafesa","year":"2023","journal-title":"J Transl Med"},{"key":"2026021803542420300_ehf215103-bib-0114","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1161\/CIRCEP.111.967265","article-title":"Spontaneous ventricular fibrillation in right ventricular failure secondary to chronic pulmonary hypertension","volume":"5","author":"Umar","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2026021803542420300_ehf215103-bib-0115","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12933-021-01293-8","article-title":"Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis","volume":"20","author":"Li","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"2026021803542420300_ehf215103-bib-0116","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1007\/s00210-023-02409-5","article-title":"Dapagliflozin protects against dilated cardiomyopathy progression by targeting NLRP3 inflammasome activation","volume":"396","author":"Hu","year":"2023","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2026021803542420300_ehf215103-bib-0117","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12020-021-02644-x","article-title":"Use of SGLT2 inhibitors and occurrence of noninfectious respiratory disorders: a meta-analysis of large randomized trials of SGLT2 inhibitors","volume":"73","author":"Qiu","year":"2021","journal-title":"Endocrine"},{"key":"2026021803542420300_ehf215103-bib-0118","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1161\/CIRCULATIONAHA.120.052503","article-title":"Empagliflozin effects on pulmonary artery pressure in patients with heart failure: results from the EMBRACE-HF trial","volume":"143","author":"Nassif","year":"2021","journal-title":"Circulation"},{"key":"2026021803542420300_ehf215103-bib-0119","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1002\/ehf2.12850","article-title":"Effects of dapagliflozin on congestion assessed by remote pulmonary artery pressure monitoring","volume":"7","author":"Mullens","year":"2020","journal-title":"ESC Heart Fail"},{"key":"2026021803542420300_ehf215103-bib-0120","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2024.01.006","article-title":"Dapagliflozin in patients with a failing systemic right ventricle: results from the DAPA-SERVE trial","volume":"1","author":"Fusco","year":"2024","journal-title":"JACC: Heart Fail"},{"key":"2026021803542420300_ehf215103-bib-0121","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1093\/eurheartj\/ehv512","article-title":"Left ventricular heart failure and pulmonary hypertension","volume":"37","author":"Rosenkranz","year":"2016","journal-title":"Eur Heart J"},{"key":"2026021803542420300_ehf215103-bib-0122","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01970-w","article-title":"Left ventricular remodeling response to SGLT2 inhibitors in heart failure: an updated meta-analysis of randomized controlled studies","volume":"22","author":"Carluccio","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"2026021803542420300_ehf215103-bib-0123","doi-asserted-by":"publisher","first-page":"929","DOI":"10.4070\/kcj.2017.0081","article-title":"Relationship between pulmonary artery stiffness and functional capacity in patients with heart failure with reduced ejection fraction","volume":"47","author":"Yildirim","year":"2017","journal-title":"Korean Circ J"},{"key":"2026021803542420300_ehf215103-bib-0124","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/ejhf.2333","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"24","author":"McDonagh","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"2026021803542420300_ehf215103-bib-0125","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1253\/circj.CJ-20-0341","article-title":"Dapagliflozin influences ventricular hemodynamics and exercise-induced pulmonary hypertension in type 2 diabetes patients\u2014a randomized controlled trial","volume":"84","author":"Kayano","year":"2020","journal-title":"Circ J"},{"key":"2026021803542420300_ehf215103-bib-0126","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1093\/ehjci\/jew011","article-title":"Normal range and usefulness of right ventricular systolic strain to detect subtle right ventricular systolic abnormalities in patients with heart failure: a multicentre study","volume":"18","author":"Morris","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026021803542420300_ehf215103-bib-0127","doi-asserted-by":"publisher","first-page":"563","DOI":"10.5603\/CJ.a2017.0051","article-title":"Echocardiographic evaluation of right ventricular systolic function: the traditional and innovative approach","volume":"24","author":"Smolarek","year":"2017","journal-title":"Cardiol J"},{"key":"2026021803542420300_ehf215103-bib-0128","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3390\/jcm12010042","article-title":"Impact of SGLT2 inhibitor therapy on right ventricular function in patients with heart failure and reduced ejection fraction","volume":"12","author":"Mustapic","year":"2022","journal-title":"J Clin Med"},{"key":"2026021803542420300_ehf215103-bib-0129","doi-asserted-by":"publisher","first-page":"109","DOI":"10.17219\/acem\/143433","article-title":"Impact of sacubitril\/valsartan on systolic heart failure: right heart location and clustering analysis","volume":"31","author":"Bouali","year":"2022","journal-title":"Adv Clin Exp Med"},{"key":"2026021803542420300_ehf215103-bib-0130","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006894","article-title":"Prognostic value of right ventricular dysfunction in heart failure with reduced ejection fraction: superiority of longitudinal strain over tricuspid annular plane systolic excursion","volume":"11","author":"Carluccio","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"2026021803542420300_ehf215103-bib-0131","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3390\/clinpract13060116","article-title":"Improvement in left and right ventricular function after introduction of SGLT2 inhibitors in heart failure outpatients with reduced ejection fraction","volume":"13","author":"Alcidi","year":"2023","journal-title":"Clin Pract"},{"key":"2026021803542420300_ehf215103-bib-0132","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/cpf.12857","article-title":"Switch to gliflozins and biventricular function improvement in patients with chronic heart failure and diabetes mellitus","volume":"44","author":"Correale","year":"2024","journal-title":"Clin Physiol Funct Imaging"},{"key":"2026021803542420300_ehf215103-bib-0133","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1002\/ehf2.14331","article-title":"Rationale and design of the Biventricular Evaluation of Gliflozins effects In chroNic Heart Failure: BEGIN-HF study","volume":"10","author":"Correale","year":"2023","journal-title":"ESC Heart Fail."},{"key":"2026021803542420300_ehf215103-bib-0134","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1093\/eurheartj\/ehab765","article-title":"SGLT2 inhibitors: the statins of the 21st century","volume":"43","author":"Braunwald","year":"2022","journal-title":"Eur Heart J"},{"key":"2026021803542420300_ehf215103-bib-0135","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.yjmcc.2017.11.016","article-title":"Iron status and oxidative stress in the aged rabbit heart","volume":"114","author":"Lapenna","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"2026021803542420300_ehf215103-bib-0136","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.healun.2015.06.015","article-title":"Right ventricular failure after left ventricular assist devices","volume":"34","author":"Lampert","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"2026021803542420300_ehf215103-bib-0137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.healun.2005.07.008","article-title":"Right heart failure after left ventricular assist device implantation in patients with chronic congestive heart failure","volume":"25","author":"Dang","year":"2006","journal-title":"J Heart Lung Transplant"},{"key":"2026021803542420300_ehf215103-bib-0138","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.jchf.2023.04.014","article-title":"Late right heart failure after left ventricular assist device implantation: contemporary insights and future perspectives","volume":"11","author":"Rajapreyar","year":"2023","journal-title":"JACC Heart Fail"},{"key":"2026021803542420300_ehf215103-bib-0139","doi-asserted-by":"publisher","first-page":"765","DOI":"10.2459\/JCM.0000000000001531","article-title":"The safety of sodium-glucose co-transporter 2 inhibitors in patients with left ventricular assist device\u2014a single center experience","volume":"24","author":"Moady","year":"2023","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"2026021803542420300_ehf215103-bib-0140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2023.131259","article-title":"Safety and tolerability of sodium-glucose cotransporter-2 inhibitors in bridge-to-transplant patients supported with centrifugal-flow left ventricular assist devices","volume":"391","author":"Chavali","year":"2023","journal-title":"Int J Cardiol"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/2\/1045\/66952690\/eschf_12_2_1045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/2\/1045\/66952690\/eschf_12_2_1045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T08:54:38Z","timestamp":1771404878000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/12\/2\/1045\/8487930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,6]]},"references-count":140,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,10,6]]},"published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.15103","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2024,10,6]]},"assertion":[{"value":"2024-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}