{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:28:47Z","timestamp":1791646127859,"version":"4.3.4"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":464,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear. Ferroptosis is an iron dependent form of cell death and has been proved to be an important role in heart failure. The aim of this study is to determine whether Dapa improves obesity-related heart failure by regulating ferroptosis in high-fat diet rats. Methods and results: Male SD rats were fed a high-fat diet for 12 weeks and confirmed of obese heart failure by metabolic parameters and cardiac ultrasound. Being overweight by 20% compared with the normal group, with elevated systolic blood pressure and abnormal levels of insulin and blood lipid (TG and LDL-c), is recognized as obesity. The obese rats with reduced EF, FS, and E\/A shown on ultrasound are defined as the obese heart failure (OHF) group. Histological tests confirmed the more pronounced cardiac fibrosis, mitochondrial volume and collagen deposition in OHF group. Dapa treatment effectively reduced body weight, INS, ISI\/IRI index, TG and HDL-C levels (P &amp;lt; 0.05). Also, Dapa administration can slightly decrease the SBP and DBP levels; however, there was no statistical difference among those four groups. Furthermore, Dapa treatment can significantly improve high-fat induced systolic and diastolic dysfunction via regulating cardiac histological abnormalities, including less obvious mitochondrial swelling, muscle fibre dissolution and collagen deposition. Additionally, genes from the OHF group were used by GO enrichment analysis, and it shows that ferroptosis metabolic pathway participated in the development of obese phenotype of heart failure. More importantly, Dapa significantly inhibited Fe2+ and MDA levels (P &amp;lt; 0.05), but augmented GSH content (P &amp;lt; 0.05). In addition, the mRNAs and protein expression of some important regulators of ferroptosis, like GPX4, SLC7A11, FTH1 and FPN1, were all decreased after Dapa intervention. Conclusion: Dapa improved high-fat induced obese cardiac dysfunction via regulating ferroptosis pathway.<\/jats:p>","DOI":"10.1002\/ehf2.15150","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T03:40:17Z","timestamp":1731296417000},"page":"1358-1373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dapagliflozin Alleviates High-Fat-Induced Obesity Cardiomyopathy by Inhibiting Ferroptosis"],"prefix":"10.1093","volume":"12","author":[{"given":"Di","family":"Chen","sequence":"first","affiliation":[{"name":"Affiliated Zhongshan Hospital of Dalian University , Dalian ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Shi","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University , Xiamen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University , Xiamen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhu","family":"Miao","sequence":"additional","affiliation":[{"name":"Yancheng No. 1 People's Hospital , Yancheng ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Zhongshan Hospital of Dalian University , Dalian ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Zhongshan Hospital of Dalian University , Dalian ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) , Dalian ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lou","sequence":"additional","affiliation":[{"name":"The Second Hospital of Dalian Medical University , Dalian ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"2026021804070018700_ehf215150-bib-0001","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.120.007292","article-title":"Obesity prevalence and risks among Chinese adults: findings from the China PEACE Million Persons Project, 2014-2018","volume":"14","author":"Mu","year":"2021","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2026021804070018700_ehf215150-bib-0002","article-title":"Overweight, hypertension and cardiovascular disease: focus on adipocytokines, insulin, weight changes and natriuretic peptides","volume":"62","author":"Seven","year":"2015","journal-title":"Dan Med J"},{"key":"2026021804070018700_ehf215150-bib-0003","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3109\/00365528709095871","article-title":"Dietary fibre, diabetes and obesity","volume":"11","author":"Smith","year":"1987","journal-title":"Int J Obes (Lond)"},{"key":"2026021804070018700_ehf215150-bib-0004","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/ncpcardio0943","article-title":"Obesity cardiomyopathy: pathogenesis and pathophysiology","volume":"4","author":"Wong","year":"2007","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"2026021804070018700_ehf215150-bib-0005","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1080\/17512433.2023.2173574","article-title":"Clinical pharmacology of SGLT-2 inhibitors in heart failure","volume":"16","author":"Velliou","year":"2023","journal-title":"Expert Rev Clin Pharmacol"},{"key":"2026021804070018700_ehf215150-bib-0006","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1002\/ehf2.14297","article-title":"Indirect comparison of SGLT2 inhibitors in patients with established heart failure: evidence based on Bayesian methods","volume":"10","author":"Chen","year":"2023","journal-title":"ESC Heart Fail"},{"key":"2026021804070018700_ehf215150-bib-0007","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1056\/NEJMoa2022190","article-title":"Cardiovascular and renal outcomes with empagliflozin in heart failure","volume":"383","author":"Packer","year":"2020","journal-title":"N Engl J Med"},{"key":"2026021804070018700_ehf215150-bib-0008","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1056\/NEJMoa2107038","article-title":"Empagliflozin in heart failure with a preserved ejection fraction","volume":"385","author":"Anker","year":"2021","journal-title":"N Engl J Med"},{"key":"2026021804070018700_ehf215150-bib-0009","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"2026021804070018700_ehf215150-bib-0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109754","article-title":"Paeoniflorin alleviates ischemia\/reperfusion induced acute kidney injury by inhibiting Slc7a11-mediated ferroptosis","volume":"116","author":"Ma","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"2026021804070018700_ehf215150-bib-0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110205","article-title":"The SPATA2\/CYLD pathway contributes to doxorubicin-induced cardiomyocyte ferroptosis via enhancing ferritinophagy","volume":"368","author":"Zhou","year":"2022","journal-title":"Chem Biol Interact"},{"key":"2026021804070018700_ehf215150-bib-0012","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1172\/JCI126428","article-title":"Ferroptotic cell death and TLR4\/Trif signaling initiate neutrophil recruitment after heart transplantation","volume":"129","author":"Li","year":"2019","journal-title":"J Clin Invest"},{"key":"2026021804070018700_ehf215150-bib-0013","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.freeradbiomed.2020.07.026","article-title":"Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell","volume":"160","author":"Bai","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"2026021804070018700_ehf215150-bib-0014","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2022.0169","article-title":"Dapagliflozin alleviates diabetic kidney disease via HIF1\u03b1\/HO1 mediated ferroptosis [published online ahead of print, 2023 Jun 5]","author":"Wang","year":"2023","journal-title":"Antioxid Redox Signal"},{"key":"2026021804070018700_ehf215150-bib-0015","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1590\/1519-6984.221405","article-title":"Murinometric measurements and retroperitoneal adipose tissue in young rats exposed to the high-fat diet: is there correlation?","volume":"81","author":"Mac\u00eado","year":"2021","journal-title":"Braz J Biol"},{"key":"2026021804070018700_ehf215150-bib-0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118485","article-title":"Sulforaphene inhibits the progression of osteosarcoma via regulating FSTL1\/NF-\u03baB pathway","volume":"263","author":"Zhang","year":"2020","journal-title":"Life Sci"},{"key":"2026021804070018700_ehf215150-bib-0017","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201800311","article-title":"GPX4 at the crossroads of lipid homeostasis and Ferroptosis","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"key":"2026021804070018700_ehf215150-bib-0018","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076382","article-title":"The role of oxidative stress enhanced by adiposity in cardiometabolic diseases","volume":"24","author":"\u015awi\u0105tkiewicz","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026021804070018700_ehf215150-bib-0019","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.161229","article-title":"Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders","volume":"8","author":"Zhao","year":"2023","journal-title":"JCI Insight"},{"key":"2026021804070018700_ehf215150-bib-0020","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-049063","article-title":"Metabolically healthy obesity and the risk of all-cause and cardiovascular disease mortality in a Korean population: a prospective cohort study","volume":"11","author":"Kim","year":"2021","journal-title":"BMJ Open"},{"key":"2026021804070018700_ehf215150-bib-0021","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1161\/CIRCULATIONAHA.115.016801","article-title":"Body mass index, abdominal fatness, and heart failure incidence and mortality: a systematic review and dose-response meta-analysis of prospective studies","volume":"133","author":"Aune","year":"2016","journal-title":"Circulation"},{"key":"2026021804070018700_ehf215150-bib-0022","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"2026021804070018700_ehf215150-bib-0023","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1136\/heartjnl-2020-318242","article-title":"Epicardial adipose tissue in obesity-related cardiac dysfunction","volume":"108","author":"Ayton","year":"2022","journal-title":"Heart"},{"key":"2026021804070018700_ehf215150-bib-0024","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1152\/physrev.00030.2020","article-title":"Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications","volume":"101","author":"Ren","year":"2021","journal-title":"Physiol Rev"},{"key":"2026021804070018700_ehf215150-bib-0025","first-page":"190","article-title":"Obesity, heart failure and sudden death","volume":"12","author":"Contaldo","year":"2002","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2026021804070018700_ehf215150-bib-0026","doi-asserted-by":"publisher","first-page":"890","DOI":"10.2741\/4758","article-title":"Mechanisms of obesity-induced metabolic and vascular dysfunctions","volume":"24","author":"Atawia","year":"2019","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2026021804070018700_ehf215150-bib-0027","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061321","article-title":"Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction","volume":"18","author":"Achari","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2026021804070018700_ehf215150-bib-0028","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0556-3","article-title":"Raloxifene inhibits adipose tissue inflammation and adipogenesis through Wnt regulation in ovariectomized rats and 3\u2009T3-L1 cells","volume":"26","author":"Shen","year":"2019","journal-title":"J Biomed Sci"},{"key":"2026021804070018700_ehf215150-bib-0029","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1161\/CIRCRESAHA.119.315896","article-title":"Metabolic inflammation and insulin resistance in obesity","volume":"126","author":"Wu","year":"2020","journal-title":"Circ Res"},{"key":"2026021804070018700_ehf215150-bib-0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114591","article-title":"Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1\/Nrf2 pathway","volume":"162","author":"Zhang","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"2026021804070018700_ehf215150-bib-0031","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1011669","article-title":"Canagliflozin mitigates ferroptosis and improves myocardial oxidative stress in mice with diabetic cardiomyopathy","volume":"13","author":"Du","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026021804070018700_ehf215150-bib-0032","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16681","article-title":"Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review","volume":"11","author":"Liu","year":"2023","journal-title":"PeerJ"},{"key":"2026021804070018700_ehf215150-bib-0033","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1142310","article-title":"Ferroptosis: roles and molecular mechanisms in diabetic cardiomyopathy","volume":"14","author":"Zhao","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026021804070018700_ehf215150-bib-0034","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1080\/14779072.2022.2057949","article-title":"Beneficial cardiovascular and remodeling effects of SGLT 2 inhibitors","volume":"20","author":"Chrysant","year":"2022","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"2026021804070018700_ehf215150-bib-0035","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.pcad.2019.07.005","article-title":"Mechanistic insights regarding the role of SGLT2 inhibitors and GLP1 agonist drugs on cardiovascular disease in diabetes","volume":"62","author":"Garg","year":"2019","journal-title":"Prog Cardiovasc Dis"},{"key":"2026021804070018700_ehf215150-bib-0036","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1161\/CIRCULATIONAHA.116.026807","article-title":"Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction","volume":"136","author":"Obokata","year":"2017","journal-title":"Circulation"},{"key":"2026021804070018700_ehf215150-bib-0037","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.amjcard.2013.08.047","article-title":"Effects of interleukin-1 blockade with anakinra on aerobic exercise capacity in patients with heart failure and preserved ejection fraction (from the D-HART pilot study)","volume":"113","author":"van Tassell","year":"2014","journal-title":"Am J Cardiol"},{"key":"2026021804070018700_ehf215150-bib-0038","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1161\/CIRCULATIONAHA.118.038010","article-title":"Anti-inflammatory therapy with canakinumab for the prevention of hospitalization for heart failure","volume":"139","author":"Everett","year":"2019","journal-title":"Circulation"},{"key":"2026021804070018700_ehf215150-bib-0039","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.2337\/db19-0991","article-title":"Empagliflozin ameliorates obesity-related cardiac dysfunction by regulating Sestrin2-mediated AMPK-mTOR signaling and redox homeostasis in high-fat diet-induced obese mice","volume":"69","author":"Sun","year":"2020","journal-title":"Diabetes"},{"key":"2026021804070018700_ehf215150-bib-0040","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076842","article-title":"Sodium glucose cotransporter 2 (SGLT2) inhibitor ameliorate metabolic disorder and obesity induced cardiomyocyte injury and mitochondrial remodeling","volume":"24","author":"Jhuo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026021804070018700_ehf215150-bib-0041","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1317620","article-title":"Dapagliflozin alleviates myocardial ischemia\/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition","volume":"14","author":"Chen","year":"2023","journal-title":"Front Pharmacol"},{"key":"2026021804070018700_ehf215150-bib-0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121207","article-title":"Empagliflozin attenuates trastuzumab-induced cardiotoxicity through suppression of DNA damage and ferroptosis","volume":"312","author":"Min","year":"2023","journal-title":"Life Sci"},{"key":"2026021804070018700_ehf215150-bib-0043","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1078205","article-title":"Dapagliflozin alleviates myocardial ischemia\/reperfusion injury by reducing ferropotosis via MAPK signaling inhibition","volume":"20","author":"Chen","year":"2023","journal-title":"Front Pharmacol"},{"key":"2026021804070018700_ehf215150-bib-0044","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9735555","article-title":"Dapagliflozin ameliorates renal tubular ferroptosis in diabetes via SLC40A1 stabilization","author":"Huang","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"2026021804070018700_ehf215150-bib-0045","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s10557-023-07498-1","article-title":"Iron status screening in individuals with heart failure before initiating sodium-glucose cotransporter 2 inhibitor therapy: is it necessary?","volume":"38","author":"Cirovic","journal-title":"Cardiovasc Drugs Ther"},{"key":"2026021804070018700_ehf215150-bib-0046","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jchf.2022.10.004","article-title":"Potential interactions when prescribing SGLT2 inhibitors and intravenous iron in combination in heart failure","volume":"11","author":"Packer","year":"2023","journal-title":"JACC Heart Fail"},{"key":"2026021804070018700_ehf215150-bib-0047","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126493","article-title":"Hepcidin-ferroportin interaction controls systemic iron homeostasis","volume":"22","author":"Nemeth","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026021804070018700_ehf215150-bib-0048","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1002\/ejhf.1154","article-title":"Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function","volume":"20","author":"Hoes","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026021804070018700_ehf215150-bib-0049","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2061-8","article-title":"Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis"},{"key":"2026021804070018700_ehf215150-bib-0050","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"2026021804070018700_ehf215150-bib-0051","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105466","article-title":"Ferroptosis and its emerging roles in cardiovascular diseases","volume":"166","author":"Li","year":"2021","journal-title":"Pharmacol Res"},{"key":"2026021804070018700_ehf215150-bib-0052","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1536\/ihj.50.829","article-title":"A case of iron overload cardiomyopathy: beneficial effects of iron chelating agent and calcium channel blocker on left ventricular dysfunction","volume":"50","author":"Sugishita","year":"2009","journal-title":"Int Heart J"},{"key":"2026021804070018700_ehf215150-bib-0053","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14235896","article-title":"ACSL3 and ACSL4, distinct roles in ferroptosis and cancers","volume":"14","author":"Yang","year":"2022","journal-title":"Cancers (Basel)"},{"key":"2026021804070018700_ehf215150-bib-0054","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1021\/acschembio.5b00245","article-title":"Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death","volume":"10","author":"Dixon","year":"2015","journal-title":"ACS Chem Biol"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/2\/1358\/66953002\/eschf_12_2_1358.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/2\/1358\/66953002\/eschf_12_2_1358.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:07:09Z","timestamp":1771405629000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/12\/2\/1358\/8488006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":54,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,11,11]]},"published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.15150","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"2023-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}