{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:31:12Z","timestamp":1787985072998,"version":"build-2784847793"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":436,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>SPARCL1 was recently identified as a biomarker of right ventricular (RV) maladaptation in patients with pulmonary hypertension (PH), and N-terminal pro-brain natriuretic protein (NT-proBNP) is an established biomarker of RV failure in PH. The present study investigated whether NT-proBNP and SPARCL1 concentrations are associated with load-independent parameters of RV function and RV-to-pulmonary artery (RV\u2013PA) coupling as measured using invasive pressure\u2013volume (PV) loops in the RV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SPARCL1 and NT-proBNP were measured in the plasma of patients with idiopathic pulmonary artery hypertension (IPAH, n = 73). Participants without LV or RV abnormalities served as controls (n = 28). All patients underwent echocardiography and right heart catheterization with invasive PV loop measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our cohort had more females with IPAH than the control group (64% vs. 35%; P = 0.01) and was older [69 (interquartile range, IQR 57\u201376) vs. 51 (IQR 35\u201362) years; P &amp;lt; 0.001]. SPARCL1 and NT-proBNP levels were significantly higher in patients with IPAH as compared with controls (P &amp;lt; 0.0001). Patients with IPAH and maladaptive RV remodelling had higher SPARCL1 and NT-proBNP concentrations than those with adaptive RV remodelling (P &amp;lt; 0.01). Both SPARCL1 and NT-proBNP were good predictors of maladaptive RV remodelling in receiver operating characteristic analysis [area under the curve (AUC) (AUCSPARCL1 = 0.75, AUCNT-proBNP = 0.72, P = 0.36 for AUCSPARCL1 vs. AUCNT-proBNP]. The combined predictive value of SPARCL1 and NT-proBNP (AUC 0.78, P &amp;lt; 0.001) for maladaptive RV was numerically higher than that of either SPARCL1 or NT-proBNP alone (P = 0.16 for AUCSPARCL1 + NT-proBNP vs. AUCNT-proBNP and P = 0.18 for AUCSPARCL1 + NT-proBNP vs. AUCSPARC1). SPARCL1 showed numerically a tendency for a better predictive power than NT-proBNP for parameters of early maladaptive RV remodelling such as RV ejection fraction &amp;lt; 50% (AUCSPARCL1 = 0.77, AUCNT-proBNP = 0.67, P = 0.06 for AUCSPARCL1 vs. AUCNT-proBNP), RV end-diastolic diameter &amp;gt; 42 mm (AUCSPARCL1 = 0.72, AUCNT-proBNP = 0.65, P = 0.19 for AUCSPARCL1 vs. AUCNT-proBNP) and RV end-systolic volume index RVESVI &amp;gt; 31 mL\/m2 (AUCSPARCL1 = 0.78, AUCNT-proBNP = 0.71, PP = 0.10 for AUCSPARCL1 vs. AUCNT-proBNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SPARCL1 and NT-proBNP are good predictors of maladaptive RV remodelling and RV\u2013PA uncoupling in IPAH patients. SPARCL1 may be a better predictor of early maladaptive RV remodelling than NT-proBNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15159","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T01:45:32Z","timestamp":1733795132000},"page":"1416-1426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["SPARCL1 and NT-proBNP as Biomarkers of Right Ventricular-to-Pulmonary Artery Uncoupling in Pulmonary Hypertension"],"prefix":"10.1093","volume":"12","author":[{"given":"Oliver","family":"D\u00f6rr","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology, University of Giessen , Giessen ,","place":["Germany"]},{"name":"Cardioangiological Center Bethanien (CCB) , Frankfurt ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Rhine-Main , Bad Nauheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4379-4424","authenticated-orcid":false,"given":"Stanislav","family":"Keranov","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University of Giessen , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"van Wickern","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University of Giessen , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Nef","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Vascular Center Bad Segeberg , Bad Segeberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University of Giessen , Giessen ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Rhine-Main , Bad Nauheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University of Giessen , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Troidl","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University of Giessen , Giessen ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Rhine-Main , Bad Nauheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Sossalla","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University of Giessen , Giessen ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Rhine-Main , Bad Nauheim ,","place":["Germany"]},{"name":"Department of Cardiology, Kerckhoff Heart and Lung Center , Bad Nauheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Voss","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Rhine-Main , Bad Nauheim ,","place":["Germany"]},{"name":"Department of Cardiology, Kerckhoff Heart and Lung Center , Bad Nauheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Liebetrau","sequence":"additional","affiliation":[{"name":"Cardioangiological Center Bethanien (CCB) , Frankfurt ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Rhine-Main , Bad Nauheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel J.","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL) , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Gall","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL) , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Seeger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL) , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardeschir","family":"Ghofrani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL) , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athiththan","family":"Yogeswaran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL) , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khodr","family":"Tello","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL) , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"2026021804034620400_ehf215159-bib-0001","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/bph.14866","article-title":"Right heart failure in pulmonary hypertension: diagnosis and new perspectives on vascular and direct right ventricular treatment","volume":"178","author":"Tello","year":"2021","journal-title":"Br J Pharmacol"},{"key":"2026021804034620400_ehf215159-bib-0002","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01900-2018","article-title":"Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update","volume":"53","author":"Vonk Noordegraaf","year":"2019","journal-title":"Eur Respir J"},{"key":"2026021804034620400_ehf215159-bib-0003","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"key":"2026021804034620400_ehf215159-bib-0004","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1161\/CIRCULATIONAHA.118.039360","article-title":"Association of N-terminal pro brain natriuretic peptide and long-term outcome in patients with pulmonary arterial hypertension","volume":"139","author":"Chin","year":"2019","journal-title":"Circulation"},{"key":"2026021804034620400_ehf215159-bib-0005","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0009-2020","article-title":"BNP\/NT-proBNP in pulmonary arterial hypertension: time for point-of-care testing?","volume":"29","author":"Lewis","year":"2020","journal-title":"European Respiratory Review: An Official Journal of the European Respiratory Society"},{"key":"2026021804034620400_ehf215159-bib-0006","doi-asserted-by":"publisher","first-page":"27621","DOI":"10.1074\/jbc.M510507200","article-title":"Matricellular hevin regulates decorin production and collagen assembly","volume":"281","author":"Sullivan","year":"2006","journal-title":"J Biol Chem"},{"key":"2026021804034620400_ehf215159-bib-0007","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1292\/jvms.17-0053","article-title":"Expression profile of matricellular proteins in hypertrophied right ventricle of monocrotaline-induced pulmonary hypertensive rats","volume":"79","author":"Imoto","year":"2017","journal-title":"J Vet Med Sci"},{"key":"2026021804034620400_ehf215159-bib-0008","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1080\/1354750X.2020.1745889","article-title":"SPARCL1 as a biomarker of maladaptive right ventricular remodelling in pulmonary hypertension","volume":"25","author":"Keranov","year":"2020","journal-title":"Biomarkers: biochemical indicators of exposure, response, and susceptibility to chemicals"},{"key":"2026021804034620400_ehf215159-bib-0009","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.healun.2017.02.016","article-title":"The Giessen Pulmonary Hypertension Registry: survival in pulmonary hypertension subgroups","volume":"36","author":"Gall","year":"2017","journal-title":"J Heart Lung Transpl"},{"key":"2026021804034620400_ehf215159-bib-0010","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/ehjci\/jew041","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of, Cardiovascular Imaging","volume":"17","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026021804034620400_ehf215159-bib-0011","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1183\/16000617.0062-2015","article-title":"Right heart catheterisation: best practice and pitfalls in pulmonary hypertension","volume":"24","author":"Rosenkranz","year":"2015","journal-title":"Eur Respir Rev"},{"key":"2026021804034620400_ehf215159-bib-0012","doi-asserted-by":"publisher","first-page":"H1625","DOI":"10.1152\/ajpheart.01023.2002","article-title":"Single-beat estimation of right ventricular end-systolic pressure\u2013volume relationship","volume":"284","author":"Brimioulle","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026021804034620400_ehf215159-bib-0013","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1183\/09031936.00156714","article-title":"Clinical relevance of right ventricular diastolic stiffness in pulmonary hypertension","volume":"45","author":"Trip","year":"2015","journal-title":"Eur Respir J"},{"key":"2026021804034620400_ehf215159-bib-0014","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1161\/CIRCULATIONAHA.113.001873","article-title":"Right ventricular diastolic impairment in patients with pulmonary arterial hypertension","volume":"128","author":"Rain","year":"2013","journal-title":"Circulation"},{"key":"2026021804034620400_ehf215159-bib-0015","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.121.009101","article-title":"Invasive right ventricular pressure\u2013volume analysis: basic principles, clinical applications, and practical recommendations","volume":"15","author":"Brener","year":"2022","journal-title":"Circ Heart Fail"},{"key":"2026021804034620400_ehf215159-bib-0016","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01889-2018","article-title":"Risk stratification and medical therapy of pulmonary arterial hypertension","volume":"53","author":"Galie","year":"2019","journal-title":"Eur Respir J"},{"key":"2026021804034620400_ehf215159-bib-0017","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1152\/physrev.00008.2011","article-title":"Matricellular proteins in cardiac adaptation and disease","volume":"92","author":"Frangogiannis","year":"2012","journal-title":"Physiol Rev"},{"key":"2026021804034620400_ehf215159-bib-0018","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jacc.2016.10.047","article-title":"The relationship between the right ventricle and its load in pulmonary hypertension","volume":"69","author":"Noordegraaf","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2026021804034620400_ehf215159-bib-0019","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002636","article-title":"Right ventricular myocardial stiffness in experimental pulmonary arterial hypertension: relative contribution of fibrosis and myofibril stiffness. Circulation","volume":"9","author":"Rain","year":"2016","journal-title":"Heart failure"},{"key":"2026021804034620400_ehf215159-bib-0020","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1016\/j.jcmg.2018.12.032","article-title":"Cardiac magnetic resonance imaging-based right ventricular strain analysis for assessment of coupling and diastolic function in pulmonary hypertension","volume":"12","author":"Tello","year":"2019","journal-title":"J Am Coll Cardiol Img"},{"key":"2026021804034620400_ehf215159-bib-0021","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005512","article-title":"Reserve of right ventricular-arterial coupling in the setting of chronic overload","volume":"12","author":"Tello","year":"2019","journal-title":"Circ Heart Fail"},{"key":"2026021804034620400_ehf215159-bib-0022","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13227","article-title":"Ventriculo-arterial coupling detects occult RV dysfunction in chronic thromboembolic pulmonary vascular disease","volume":"5","author":"Axell","year":"2017","journal-title":"Physiol Rep"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/2\/1416\/66952772\/eschf_12_2_1416.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/2\/1416\/66952772\/eschf_12_2_1416.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:03:51Z","timestamp":1771405431000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/12\/2\/1416\/8487978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,12,9]]},"published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.15159","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2024,12,9]]},"assertion":[{"value":"2024-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}