{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T10:12:56Z","timestamp":1771409576322,"version":"3.50.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":338,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Chinese Academy of Chinese Medical Sciences Innovation Fund for Medical Science","award":["2021-I2M-1-009"],"award-info":[{"award-number":["2021-I2M-1-009"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>There are limited tools to predict long-term mortality among patients hospitalized with acute heart failure (AHF) in China. This study aimed to develop and validate a model to predict long-term mortality risk among patients who were hospitalized with AHF and discharged alive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from China Patient-Centred Evaluative Assessment of Cardiac Events Prospective Heart Failure Study. Multivariate Cox proportional hazard model was used to develop and internal validate a model to predict 4 year mortality risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 4875 patients hospitalized for AHF, of whom 2066 (42.38%) died within 4 years following admission, with a median survival time of 3.91 (interquartile range: 1.67, 4.00) years. We selected 13 predictors to establish the model, including age, medical history of hypertension, chronic obstructive pulmonary disease and HF, systolic blood pressure, blood urea nitrogen, albumin, high-sensitivity troponin T, N-terminal pro-brain natriuretic peptide, serum creatine, Kansas City Cardiomyopathy Questionnaire-12 score and left ventricular ejection fraction. The model showed a reasonable performance with the discrimination [C-index was 0.726 (95% confidence interval, CI: 0.714, 0.739) in the development cohort and 0.727 (95% CI: 0.708, 0.747) in the validation cohort]. We then built a point-based risk score algorithm and the patients were stratified to low-risk (0\u201314), intermediate-risk (15\u201319) and high-risk (\u226520) groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>By using readily accessible predictors, we developed and validated a risk prediction model to predict 4 year mortality risk among patients who were hospitalized with AHF and discharged alive. This model proved beneficial for individual risk stratification and facilitating ongoing enhancements in patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15207","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T05:41:47Z","timestamp":1742190107000},"page":"1992-2009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Classification for Long-Term Mortality Among Patients with Acute Heart Failure: China PEACE 4YMortality"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4232-8699","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, 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