{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T10:13:26Z","timestamp":1771409606616,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":359,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Korea Health Technology R&D Project"},{"name":"Ministry of Health and Welfare, Republic of Korea","award":["HI22C0154"],"award-info":[{"award-number":["HI22C0154"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Few studies have examined the incidence, prevalence, survival rate and death risk for non-rheumatic and rheumatic aortic stenosis (AS; RAS), aortic insufficiency (AR; RAR) and aortic stenosis with insufficiency (ASAR; RASAR). This study aims to identify the epidemiology of AS, AR, ASAR, RAS, RAR and RASAR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Data were collected from newly diagnosed non-rheumatic and rheumatic aortic valve disorders (AVD, ICD-10: I35 and I06, n = 101 895, female: male = 6:4) including AS, AR, ASAR, RAS, RAR and RASAR, excluding congenital heart disease. The data were sourced from the National Health Insurance Service in Korea from 2006 through 2017. Among all AVD, AR had the highest distribution. More than 70% of AVD patients were age \u2265 60 years. The age-standardized incidence of non-rheumatic AVD remained stable over the decade while the age-standardized prevalence increased. Conversely, both the incidence and prevalence of rheumatic AVD decreased. The 10 year survival rates (SR) of AS (49.2%), ASAR (50.2%) and RAS (51.4%) were lower than those for AR (64.5%) and RAR (69.2%). The adjusted hazard ratio for AVD was higher in individuals who were older, male, had a lower income level, diabetes mellitus, myocardial infarction, heart failure, atrial fibrillation, stroke, chronic kidney disease or malignant neoplasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over 70% of AVD patients were age \u2265 60 years. The 10 year SR of AS, ASAR and RAS exhibited similar patterns, all of which were lower than the SR for other AVD. AVD portends a worse prognosis in older individuals, males, those with lower income levels and those with comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15249","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T11:19:00Z","timestamp":1741605540000},"page":"2245-2255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Incidence, Prevalence and Death of Aortic Stenosis and Aortic Insufficiency in a Nationwide Korean Study"],"prefix":"10.1093","volume":"12","author":[{"given":"Shin Yi","family":"Jang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-847X","authenticated-orcid":false,"given":"Sung-Ji","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"2026021804241481700_ehf215249-bib-0001","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ijcard.2014.04.112","article-title":"Changes in the etiology of valvular heart disease in the rapidly aging Korean population","volume":"174","author":"Jang","year":"2014","journal-title":"Int J Cardiol"},{"key":"2026021804241481700_ehf215249-bib-0002","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1002\/ehf2.13957","article-title":"Temporal trends in incidence, prevalence, and death of aortic stenosis in Korea: a nationwide population-based study","volume":"9","author":"Jang","year":"2022","journal-title":"ESC Heart Fail"},{"key":"2026021804241481700_ehf215249-bib-0003","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1086\/499812","article-title":"Temporal changes in streptococcal M protein types and the near-disappearance of acute rheumatic fever in the United States","volume":"42","author":"Shulman","year":"2006","journal-title":"Clin Infect Dis"},{"key":"2026021804241481700_ehf215249-bib-0004","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1161\/01.cir.72.6.1155","article-title":"The virtual disappearance of rheumatic fever in the United States: lessons in the rise and fall of disease","volume":"72","author":"Gordis","year":"1985","journal-title":"T Duckett Jones Memorial Lecture Circulation"},{"key":"2026021804241481700_ehf215249-bib-0005","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"385","author":"GBD 2013 Mortality and Causes of Death Collaborators","year":"2015","journal-title":"Lancet"},{"key":"2026021804241481700_ehf215249-bib-0006","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1136\/heartjnl-2014-307020","article-title":"The modern epidemiology of heart valve disease","volume":"102","author":"Coffey","year":"2016","journal-title":"Heart"},{"key":"2026021804241481700_ehf215249-bib-0007","volume-title":"2012 National Health Insurance Statistical Yearbook, published by National Health Insurance Service; 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