{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:46:04Z","timestamp":1791945964044,"version":"4.3.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":344,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial secondary mitral valve regurgitation (ASMR) is a distinct anatomical subset of secondary mitral regurgitation (SMR). Evidence of the effect of transcatheter edge-to-edge repair (TEER) on left atrial (LA) anatomy and function, especially reverse remodelling (LARR), is still sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively evaluated all consecutive patients treated with TEER for mitral regurgitation (MR) in our centre between January 2013 and October 2023. Of the 597 patients with SMR, 103 patients (17.3%) met the inclusion criteria for ASMR. All patients in the ASMR group (mean age 79.4 \u00b1 6.8 years, 71% female) were symptomatic (89% NYHA \u2265 III) and had a mean logistic EuroScore of 22.5 \u00b1 12.4%. TEER was successfully performed in all patients, and invasive LA mean pressures decreased intraprocedurally from 17.8 \u00b1 5.7 to 13.1 \u00b1 4.8 mmHg (P &amp;lt; 0.001). At hospital discharge, 94% of patients had mild residual or non\/trace MR. At 1YFUP, the prevalence of residual moderate MR was 7% and 1% had severe MR. A significant reduction in LA volume compared with baseline, both at end-systole (151.4 \u00b1 64 vs. 113 \u00b1 64 mL, P &amp;lt; 0.001) and at end-diastole (119.8 \u00b1 56 vs. 91.2 \u00b1 56.9 mL, P &amp;lt; 0.001) could be observed. Seventy per cent of patients had a sustained decrease in NYHA class \u2264 II. LARR, defined as LAESV decrease \u226515% at 1YFUP, was documented in 59% of patients. These patients were more likely to have lower post-interventional mitral valve mean pressure gradients (2.2 \u00b1 0.8 mmHg vs. 2.8 \u00b1 1.1 mmHg, P = 0.02) and lower BNP at discharge and at 1 month follow-up [319 (197.8 to 526) vs. 560 (279.3 to 929), P = 0.07, and 287.5 (191.3 to 386.3) vs. 506.5 (223.3 to 935.5), P = 0.06, respectively]. A multivariate logistic regression analysis identified pre-procedural MPG (P = 0.06, OR 0.92, CI 95% 0.85\u20131.00) and BNP at discharge (P = 0.11, OR 0.99, CI 95% 0.99\u20131.00) as independent predictors for the occurrence of LARR at 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transcatheter mitral valve repair by edge-to-edge therapy represents a safe and effective therapeutic option in symptomatic patients with atrial secondary mitral regurgitation and might have the potential to induce left atrial reverse remodelling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15252","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T03:03:23Z","timestamp":1741748603000},"page":"2267-2277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Transcatheter Edge-To-Edge Repair of Atrial Secondary Mitral Regurgitation Positively Influences Atrial Remodelling"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3774-302X","authenticated-orcid":false,"given":"Aniela","family":"Petrescu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiology I, University Medical Center Mainz of the Johannes Gutenberg-University Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Geyer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I, University Medical Center Mainz of the Johannes Gutenberg-University Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian Andres","family":"Gelves Meza","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I, University Medical Center Mainz of the Johannes Gutenberg-University Mainz , Mainz ,","place":["Germany"]},{"name":"Fundacion Cardioinfantil, Instituto de Cardiologia , Bogota ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Hahad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I, University Medical Center Mainz of the Johannes Gutenberg-University Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Ruf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I, University Medical Center Mainz of the Johannes Gutenberg-University Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria Maria","family":"de Luca","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I, University Medical Center Mainz of the Johannes Gutenberg-University Mainz , Mainz ,","place":["Germany"]},{"name":"Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Hobohm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I, University Medical Center Mainz of the Johannes Gutenberg-University Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"G\u00f6\u00dfler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I, University Medical Center Mainz of the Johannes Gutenberg-University Mainz , Mainz 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