{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:36:33Z","timestamp":1790022993132,"version":"4.0.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":307,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011953","name":"Abbott Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011953","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002336","name":"Daiichi-Sankyo Company","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002336","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011953","name":"Abbott Medical Optics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011953","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Plasma volume status (PVS) is recognized as a marker of systemic congestion, but its clinical utility in patients with mitral regurgitation (MR) undergoing transcatheter edge-to-edge mitral valve repair (M-TEER) has not been well established. This study aimed to evaluate the prognostic significance of PVS in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Data from 3763 patients who underwent M-TEER were analysed from a Japanese multicentre registry. Patients were classified into functional MR (FMR) and degenerative MR (DMR) according to MR aetiology, and the median PVS values for each were calculated (FMR 12.7, DMR 14.4). The median value was used as the cut-off, stratifying the cohort into a high PVS group (n = 1882) and a low PVS group (n = 1881). All-cause mortality, cardiovascular death, and heart failure (HF) hospitalization between these two groups were compared up to 3 years in the overall, FMR, and DMR populations. The cumulative incidence rates of all-cause mortality, cardiovascular death, and HF hospitalization were higher in the high PVS group than in the low PVS group (47.0% vs. 22.2%, P &amp;lt; 0.001, 31.6% vs. 13.6%, P &amp;lt; 0.001, and 35.9% vs. 24.7%, P &amp;lt; 0.001, respectively). Similar trends in terms of all-cause mortality, cardiovascular death, and HF hospitalization were observed in the FMR and DMR cohorts (all P &amp;lt; 0.05). In the multivariate Cox regression analysis, the high PVS compared with the low PVS group was independently associated with the increased risk of all-cause death (hazard ratio [HR], 1.02; 95% confidence interval [CI], 1.01\u20131.03; P &amp;lt; 0.001), cardiovascular death (HR, 1.02; 95% CI, 1.01\u20131.03, P &amp;lt; 0.001) and HF hospitalization (HR, 1.02; 95% CI, 1.01\u20131.02, P &amp;lt; 0.001). An independent association between a high PVS and all-cause death, cardiovascular death, and HF hospitalization was also found in FMR and DMR sub-groups (all P &amp;lt; 0.05) while reducing MR severity to moderate or less after M-TEER was associated with improved outcomes in both the high and low PVS groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative PVS is a strong independent prognostic marker in patients undergoing M-TEER, correlating with increased risk of mortality and HF hospitalization. PVS may provide valuable clinical insights for patient stratification and management strategies in M-TEER patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15295","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:00:28Z","timestamp":1744862428000},"page":"2855-2865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasma Volume Status Predicting Clinical Outcomes in Patients Undergoing Transcatheter Edge-To-Edge Mitral Valve Repair"],"prefix":"10.1093","volume":"12","author":[{"given":"Ai","family":"Kagase","sequence":"first","affiliation":[{"name":"Department of Cardiology, Nagoya Heart Center , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagoya Heart Center , Nagoya ,","place":["Japan"]},{"name":"Department of Cardiology, Toyohashi Heart Center , Toyohashi ,","place":["Japan"]},{"name":"Department of Cardiology, Gifu Heart Center , Gifu ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagoya Heart Center , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaku","family":"Kawahata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagoya Heart Center , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagoya Heart Center , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Shimura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gifu Heart Center , Gifu ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Toyohashi Heart Center , Toyohashi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Sago","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Toyohashi Heart Center , Toyohashi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sakakibara Heart Institute , Fuchu ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Saji","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sakakibara Heart Institute , Fuchu ,","place":["Japan"]},{"name":"Division of Cardiovascular Medicine, Faculty of Medicine, Toho University , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Asami","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mitsui Memorial Hospital , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Enta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sendai Kosei Hospital , Sendai ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sendai Kosei Hospital , Sendai ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Shirai","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kokura Memorial Hospital , Kitakyushu ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Izumo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, St. Marianna University School of Medicine Hospital , Kawasaki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shonan Kamakura General Hospital , Kamakura ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, Teikyo University , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Amaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Cerebral and Cardiovascular Center , Suita ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Kodama","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center , Kumamoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Woman's Medical University , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, New Tokyo Hospital , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Bouta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sapporo Higashi Tokushukai Hospital , Sapporo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokai University School of Medicine , Isehara ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Toyama University Hospital , Toyama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Faculty of Medicine, Kinki University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hachinohe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sapporo Cardiovascular Clinic , Sapporo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health, Nippon Medical School , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kurashiki Central Hospital , Kurashiki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"OCEAN-Mitral Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"2026021804102039300_ehf215295-bib-0001","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1056\/NEJMoa1009355","article-title":"Percutaneous repair or surgery for mitral regurgitation","volume":"364","author":"Feldman","year":"2011","journal-title":"N Engl J Med"},{"key":"2026021804102039300_ehf215295-bib-0002","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1016\/j.jacc.2015.10.018","article-title":"Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5-year results of EVEREST II","volume":"66","author":"Feldman","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2026021804102039300_ehf215295-bib-0003","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N Engl J Med"},{"key":"2026021804102039300_ehf215295-bib-0004","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1056\/NEJMoa2314328","article-title":"Transcatheter valve repair in heart failure with moderate to severe mitral regurgitation","volume":"391","author":"Anker","year":"2024","journal-title":"N Engl J Med"},{"key":"2026021804102039300_ehf215295-bib-0005","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030747","article-title":"One-year outcomes and their relationship to residual mitral regurgitation after transcatheter edge-to-edge repair with MitraClip device: insights from the OCEAN-Mitral registry","volume":"12","author":"Kubo","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"2026021804102039300_ehf215295-bib-0006","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1161\/01.cir.80.2.299","article-title":"Edema of cardiac origin. Studies of body water and sodium, renal function, hemodynamic indexes, and plasma hormones in untreated congestive cardiac failure","volume":"80","author":"Anand","year":"1989","journal-title":"Circulation"},{"key":"2026021804102039300_ehf215295-bib-0007","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1016\/s0735-1097(02)01903-4","article-title":"The regulation and measurement of plasma volume in heart failure","volume":"39","author":"Kalra","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2026021804102039300_ehf215295-bib-0008","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1056\/NEJM200112273452610","article-title":"Prognostic importance of elevated jugular venous pressure and a third heart sound in patients with heart failure","volume":"345","author":"Drazner","year":"2001","journal-title":"N Engl J Med"},{"key":"2026021804102039300_ehf215295-bib-0009","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1093\/eurjhf\/hfq118","article-title":"Congestion in chronic systolic heart failure is related to renal dysfunction and increased mortality","volume":"12","author":"Damman","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2026021804102039300_ehf215295-bib-0010","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1161\/CIRCULATIONAHA.107.690768","article-title":"Patterns of weight change preceding hospitalization for heart failure","volume":"116","author":"Chaudhry","year":"2007","journal-title":"Circulation"},{"key":"2026021804102039300_ehf215295-bib-0011","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s10741-014-9438-7","article-title":"Water and sodium in heart failure: a spotlight on congestion","volume":"20","author":"Parrinello","year":"2015","journal-title":"Heart Fail Rev"},{"key":"2026021804102039300_ehf215295-bib-0012","volume-title":"Handbook of Dialysis","author":"Hakim","year":"2001","edition":"3rd ed."},{"key":"2026021804102039300_ehf215295-bib-0013","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/ejhf.193","article-title":"Calculated plasma volume status and prognosis in chronic heart failure","volume":"17","author":"Ling","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"2026021804102039300_ehf215295-bib-0014","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1177\/2048872617690889","article-title":"Plasma volume status predicts prognosis in patients with acute heart failure syndromes","volume":"7","author":"Yoshihisa","year":"2018","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"2026021804102039300_ehf215295-bib-0015","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/heartjnl-2018-314246","article-title":"Calculated plasma volume status and outcomes in patients undergoing coronary bypass graft surgery","volume":"105","author":"Maznyczka","year":"2019","journal-title":"Heart"},{"key":"2026021804102039300_ehf215295-bib-0016","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2257.1997.tb00004.x","article-title":"An evaluation of the SpuncritTM infra-red analyser for measurement of haematocrit","volume":"19","author":"Weatherall","year":"1997","journal-title":"Clin Lab Haematol"},{"key":"2026021804102039300_ehf215295-bib-0017","volume-title":"Harrison's Principles of Internal Medicine","author":"Longo","year":"2011","edition":"18th ed."},{"key":"2026021804102039300_ehf215295-bib-0018","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1253\/circj.CJ-20-0135","article-title":"JCS\/JSCS\/JATS\/JSVS 2020 guidelines for the management of valvular heart disease","volume":"84","author":"Izumi","year":"2020","journal-title":"Circ J"},{"key":"2026021804102039300_ehf215295-bib-0019","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1016\/j.cardfail.2021.04.023","article-title":"JCS\/JHFS 2021 guideline focused update on diagnosis and treatment of acute and chronic heart failure","volume":"27","author":"Tsutsui","year":"2021","journal-title":"J Card Fail"},{"key":"2026021804102039300_ehf215295-bib-0020","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"2026021804102039300_ehf215295-bib-0021","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jtcvs.2012.09.002","article-title":"Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document","volume":"145","author":"Kappetein","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026021804102039300_ehf215295-bib-0022","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat Med"},{"key":"2026021804102039300_ehf215295-bib-0023","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/ejhf.2809","article-title":"Association between serum albumin and outcomes in heart failure and secondary mitral regurgitation: the COAPT trial","volume":"25","author":"Feng","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"2026021804102039300_ehf215295-bib-0024","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1136\/heart.87.2.131","article-title":"Value of plasma B type natriuretic peptide measurement for heart disease screening in a Japanese population","volume":"87","author":"Nakamura","year":"2002","journal-title":"Heart"},{"key":"2026021804102039300_ehf215295-bib-0025","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1016\/j.jacc.2007.09.021","article-title":"Natriuretic peptides","volume":"50","author":"Daniels","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2026021804102039300_ehf215295-bib-0026","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/eurheartj\/ehaa968","article-title":"Influence of neprilysin inhibition on the efficacy and safety of empagliflozin in patients with chronic heart failure and a reduced ejection fraction: the EMPEROR-reduced trial","volume":"42","author":"Packer","year":"2021","journal-title":"Eur Heart J"},{"key":"2026021804102039300_ehf215295-bib-0027","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1002\/ejhf.1234","article-title":"Incremental benefit of drug therapies for chronic heart failure with reduced ejection fraction: a network meta-analysis","volume":"20","author":"Komajda","year":"2018","journal-title":"Eur J Heart Fail"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/4\/2855\/66954000\/eschf_12_4_2855.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/4\/2855\/66954000\/eschf_12_4_2855.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:10:29Z","timestamp":1771405829000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/12\/4\/2855\/8488072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4,17]]},"published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.15295","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2024-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}