{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:59:14Z","timestamp":1791917954101,"version":"4.3.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":261,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["602405"],"award-info":[{"award-number":["602405"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013263","name":"Nasjonalforeningen for folkehelsen","doi-asserted-by":"publisher","award":["19560"],"award-info":[{"award-number":["19560"]}],"id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007793","name":"Kristian Gerhard Jebsen Foundation for Exercise in Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["602405"],"award-info":[{"award-number":["602405"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013263","name":"Nasjonalforeningen for Folkehelsen","doi-asserted-by":"publisher","award":["19560"],"award-info":[{"award-number":["19560"]}],"id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007793","name":"Stiftelsen Kristian Gerhard Jebsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome accounting for half of heart failure cases. Although natriuretic peptides are the most accepted and extensively used biomarkers for heart failure, their diagnostic accuracy for HFpEF remains debatable. Here, we aimed to identify a panel of circulating microRNAs (miRNAs) as potential novel biomarkers for diagnosis of HFpEF in a preclinical model, subsequently validated in human HFpEF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In a female hypertension-induced HFpEF model [Dahl\/Salt Sensitive (DSS) rats], circulating miRNA levels were screened in the plasma via real-time quantitative polymerase chain reaction. DSS rats exhibited HFpEF features as indicated by diastolic dysfunction and adverse cardiac remodelling when fed a high-salt (8%) diet (n = 11) compared with a low-salt (0.3%) diet (n = 15). A panel of four circulating miRNAs (rno-let-7b-5p, rno-let-7e-5p, rno-miR-21-5p and rno-miR-140-3p) were found significantly altered in the DSS plasma. Clinical performance of miRNA expression analysis was assessed in publicly available datasets of human heart failure patients, including assessment of discrimination of different categories of heart failure [GSE53437; control = 30, heart failure with reduced ejection fraction (HFrEF) = 41, HFpEF = 19] and gender differences (GSE104150; female = 6, male = 10). The miRNA panel significantly discriminated HFpEF patients from healthy individuals and HFrEF patients. We also found significant downregulation of let-7b-5p and miR-21-5p in females compared with males, regardless of health status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A panel of four circulating miRNAs was differently expressed in female HFpEF rats and significantly discriminated HFpEF patients from healthy individuals and HFrEF patients. This cross-species and bench-to-bedside approach demonstrates the potential of miRNA-based panels for HFpEF diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15324","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:42:45Z","timestamp":1748914965000},"page":"3028-3041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Multi-microRNA Diagnostic Panel for Heart Failure with Preserved Ejection Fraction in Preclinical and Clinical Settings"],"prefix":"10.1093","volume":"12","author":[{"given":"Reza","family":"Parvan","sequence":"first","affiliation":[{"name":"Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natale","family":"Rolim","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas B.","family":"Gevaert","sequence":"additional","affiliation":[{"name":"Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp , Antwerp ,","place":["Belgium"]},{"name":"Department of Cardiology, Antwerp University Hospital , Antwerp ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cataliotti","sequence":"additional","affiliation":[{"name":"Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline M.","family":"van Craenenbroeck","sequence":"additional","affiliation":[{"name":"Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp , Antwerp ,","place":["Belgium"]},{"name":"Department of Cardiology, Antwerp University Hospital , Antwerp ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Adams","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Experimental Cardiology, TU Dresden, Heart Center Dresden , Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Wisl\u00f8ff","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]},{"name":"School of Human Movement and Nutrition Science, University of Queensland , Brisbane, Queensland ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-7966","authenticated-orcid":false,"given":"Gustavo Jose Justo","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the OptimEx Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"2026021804084750700_ehf215324-bib-0001","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.601364","article-title":"Biomarkers for heart failure prognosis: proteins, genetic scores and non-coding RNAs","volume":"7","author":"Shrivastava","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"2026021804084750700_ehf215324-bib-0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2023.104185","article-title":"Heart failure with preserved ejection fraction: new challenges and new hopes","volume":"53","author":"Logeart","year":"2023","journal-title":"Presse Med"},{"key":"2026021804084750700_ehf215324-bib-0003","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1136\/heartjnl-2021-319605","article-title":"Heart failure with preserved ejection fraction: recent concepts in diagnosis, mechanisms and management","volume":"108","author":"Gevaert","year":"2022","journal-title":"Heart"},{"key":"2026021804084750700_ehf215324-bib-0004","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1002\/ejhf.2019","article-title":"The HFA-PEFF and H(2) FPEF scores largely disagree in classifying patients with suspected heart failure with preserved ejection fraction","volume":"23","author":"Sanders-van Wijk","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"2026021804084750700_ehf215324-bib-0005","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/clinchem\/hvaa255","article-title":"Being in two minds\u2014The challenge of heart failure with preserved ejection fraction diagnosis with a single biomarker","volume":"67","author":"Suthahar","year":"2021","journal-title":"Clin Chem"},{"key":"2026021804084750700_ehf215324-bib-0006","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1093\/cvr\/cvy049","article-title":"Pathophysiological understanding of HFpEF: microRNAs as part of the puzzle","volume":"114","author":"Rech","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2026021804084750700_ehf215324-bib-0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27206","article-title":"Profile of serum microRNAs in heart failure with reduced and preserved ejection fraction: correlation with myocardial remodeling","volume":"10","author":"Paim","year":"2024","journal-title":"Heliyon"},{"key":"2026021804084750700_ehf215324-bib-0008","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.omtn.2019.06.013","article-title":"The different roles of miRNA-92a-2-5p and let-7b-5p in mitochondrial translation in db\/db mice","volume":"17","author":"Li","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"2026021804084750700_ehf215324-bib-0009","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/ejhf.495","article-title":"MicroRNAs in heart failure: from biomarker to target for therapy","volume":"18","author":"Vegter","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2026021804084750700_ehf215324-bib-0010","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.626699","article-title":"Circulating microRNAs may serve as biomarkers for hypertensive emergency end-organ injuries and address underlying pathways in an animal model","volume":"7","author":"Langlo","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2026021804084750700_ehf215324-bib-0011","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/ejhf.961","article-title":"Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure","volume":"20","author":"Masson","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026021804084750700_ehf215324-bib-0012","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.jacc.2018.11.060","article-title":"Combining circulating MicroRNA and NT-proBNP to detect and categorize heart failure subtypes","volume":"73","author":"Wong","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2026021804084750700_ehf215324-bib-0013","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1002\/ejhf.2700","article-title":"Diagnostic performance of microRNAs in the detection of heart failure with reduced or preserved ejection fraction: a systematic review and meta-analysis","volume":"24","author":"Parvan","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"2026021804084750700_ehf215324-bib-0014","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1093\/eurjpc\/zwab151","article-title":"miR-181c level predicts response to exercise training in patients with heart failure and preserved ejection fraction: an analysis of the OptimEx-Clin trial","volume":"28","author":"Gevaert","year":"2021","journal-title":"Eur J Prev Cardiol"},{"key":"2026021804084750700_ehf215324-bib-0015","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1161\/01.HYP.0000215579.81408.8e","article-title":"Development of heart failure in chronic hypertensive dahl rats","volume":"47","author":"Klotz","year":"2006","journal-title":"Hypertension"},{"key":"2026021804084750700_ehf215324-bib-0016","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/ejhf.223","article-title":"Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction","volume":"17","author":"Wong","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"2026021804084750700_ehf215324-bib-0017","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1159\/000493419","article-title":"Association of miR-197-5p, a circulating biomarker for heart failure, with myocardial fibrosis and adverse cardiovascular events among patients with stage C or D heart failure","volume":"141","author":"Liu","year":"2018","journal-title":"Cardiology"},{"key":"2026021804084750700_ehf215324-bib-0018","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1152\/japplphysiol.01123.2014","article-title":"High-intensity interval training attenuates endothelial dysfunction in a dahl salt-sensitive rat model of heart failure with preserved ejection fraction","volume":"119","author":"Adams","year":"2015","journal-title":"J Appl Physiol"},{"key":"2026021804084750700_ehf215324-bib-0019","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/ejhf.239","article-title":"Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle","volume":"17","author":"Bowen","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"2026021804084750700_ehf215324-bib-0020","doi-asserted-by":"publisher","first-page":"H501","DOI":"10.1152\/ajpheart.00138.2005","article-title":"Assessment of systolic and diastolic ventricular properties via pressure\u2013volume analysis: a guide for clinical, translational, and basic researchers","volume":"289","author":"Burkhoff","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026021804084750700_ehf215324-bib-0021","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1186\/s12859-019-3105-x","article-title":"MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis","volume":"20","author":"Licursi","year":"2019","journal-title":"BMC Bioinformatics"},{"key":"2026021804084750700_ehf215324-bib-0022","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.cardfail.2013.01.007","article-title":"The Singapore heart failure outcomes and phenotypes (SHOP) study and prospective evaluation of outcome in patients with heart failure with preserved left ventricular ejection fraction (PEOPLE) study: rationale and design","volume":"19","author":"Santhanakrishnan","year":"2013","journal-title":"J Card Fail"},{"key":"2026021804084750700_ehf215324-bib-0023","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the heart failure association (HFA) of the ESC","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur Heart J"},{"key":"2026021804084750700_ehf215324-bib-0024","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.jacbts.2021.12.009","article-title":"Clinical phenotypes of heart failure with preserved ejection fraction to select preclinical animal models","volume":"7","author":"van Ham","year":"2022","journal-title":"JACC Basic Transl Sci"},{"key":"2026021804084750700_ehf215324-bib-0025","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/ejhf.1621","article-title":"Phenomapping of patients with heart failure with preserved ejection fraction using machine learning-based unsupervised cluster analysis","volume":"22","author":"Segar","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"2026021804084750700_ehf215324-bib-0026","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1161\/CIRCULATIONAHA.114.010637","article-title":"Phenomapping for novel classification of heart failure with preserved ejection fraction","volume":"131","author":"Shah","year":"2015","journal-title":"Circulation"},{"key":"2026021804084750700_ehf215324-bib-0027","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jacc.2013.09.052","article-title":"Impaired systolic function by strain imaging in heart failure with preserved ejection fraction","volume":"63","author":"Kraigher-Krainer","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2026021804084750700_ehf215324-bib-0028","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","article-title":"2023 Focused update of the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur Heart J"},{"key":"2026021804084750700_ehf215324-bib-0029","doi-asserted-by":"publisher","first-page":"e895","DOI":"10.1161\/CIR.0000000000001063","article-title":"2022 AHA\/ACC\/HFSA guideline for the Management of Heart Failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"2026021804084750700_ehf215324-bib-0030","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1093\/eurheartj\/ehab911","article-title":"Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality","volume":"43","author":"Verbrugge","year":"2022","journal-title":"Eur Heart J"},{"key":"2026021804084750700_ehf215324-bib-0031","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.119.015738","article-title":"Highest obesity category associated with largest decrease in N-terminal pro-B-type natriuretic peptide in patients hospitalized with heart failure with preserved ejection fraction","volume":"9","author":"Vaishnav","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2026021804084750700_ehf215324-bib-0032","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12916-020-01764-x","article-title":"Natriuretic peptides for the detection of diastolic dysfunction and heart failure with preserved ejection fraction\u2014a systematic review and meta-analysis","volume":"18","author":"Remmelzwaal","year":"2020","journal-title":"BMC Med"},{"key":"2026021804084750700_ehf215324-bib-0033","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12933-018-0767-z","article-title":"MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin","volume":"17","author":"Dai","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"2026021804084750700_ehf215324-bib-0034","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030564","article-title":"Dynamic changes in miR-21 regulate right ventricular dysfunction in congenital heart disease-related pulmonary arterial hypertension","volume":"11","author":"Chang","year":"2022","journal-title":"Cells"},{"key":"2026021804084750700_ehf215324-bib-0035","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"2026021804084750700_ehf215324-bib-0036","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.ijcard.2013.09.002","article-title":"Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart","volume":"169","author":"Queir\u00f3s","year":"2013","journal-title":"Int J Cardiol"},{"key":"2026021804084750700_ehf215324-bib-0037","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s00109-019-01833-6","article-title":"Connecting sex differences, estrogen signaling, and microRNAs in cardiac fibrosis","volume":"97","author":"Medzikovic","year":"2019","journal-title":"J Mol Med"},{"key":"2026021804084750700_ehf215324-bib-0038","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1093\/cvr\/cvz215","article-title":"Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4","volume":"116","author":"Li","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2026021804084750700_ehf215324-bib-0039","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.jdiacomp.2019.02.001","article-title":"Hyperglycemia inhibition of endothelial miR-140-3p mediates angiogenic dysfunction in diabetes mellitus","volume":"33","author":"Wang","year":"2019","journal-title":"J Diabetes Complications"},{"key":"2026021804084750700_ehf215324-bib-0040","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ijcard.2018.08.087","article-title":"Endothelial function is disturbed in a hypertensive diabetic animal model of HFpEF: moderate continuous vs. high intensity interval training","volume":"273","author":"Schmederer","year":"2018","journal-title":"Int J Cardiol"},{"key":"2026021804084750700_ehf215324-bib-0041","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.biopha.2017.07.106","article-title":"Ellagic acid promotes ventricular remodeling after acute myocardial infarction by up-regulating miR-140-3p","volume":"95","author":"Wei","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"2026021804084750700_ehf215324-bib-0042","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1161\/01.RES.0000257913.42552.23","article-title":"MicroRNAs play an essential role in the development of cardiac hypertrophy","volume":"100","author":"Sayed","year":"2007","journal-title":"Circ Res"},{"key":"2026021804084750700_ehf215324-bib-0043","doi-asserted-by":"publisher","first-page":"23086","DOI":"10.3390\/ijms141123086","article-title":"Let-7 in cardiovascular diseases, heart development and cardiovascular differentiation from stem cells","volume":"14","author":"Bao","year":"2013","journal-title":"Int J Mol Sci"},{"key":"2026021804084750700_ehf215324-bib-0044","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.2119\/molmed.2010.00225","article-title":"Let-7 MicroRNAs induce tamoxifen sensitivity by downregulation of estrogen receptor \u03b1 signaling in breast cancer","volume":"17","author":"Zhao","year":"2011","journal-title":"Mol Med"},{"key":"2026021804084750700_ehf215324-bib-0045","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144890","article-title":"Approaching sex differences in cardiovascular non-coding RNA research","volume":"21","author":"Jusic","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026021804084750700_ehf215324-bib-0046","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/eurjhf\/hft018","article-title":"Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure","volume":"15","author":"Dickinson","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"2026021804084750700_ehf215324-bib-0047","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/10408363.2022.2128030","article-title":"Development of circulating microRNA-based biomarkers for medical decision-making: a friendly reminder of what should NOT be done","volume":"60","author":"Lakkisto","year":"2023","journal-title":"Crit Rev Clin Lab Sci"},{"key":"2026021804084750700_ehf215324-bib-0048","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s10741-023-10369-4","article-title":"Sex-specific differences in risk factors, comorbidities, diagnostic challenges, optimal management, and prognostic outcomes of heart failure with preserved ejection fraction: a comprehensive literature review","volume":"29","author":"Abubakar","year":"2023","journal-title":"Heart Fail Rev"},{"key":"2026021804084750700_ehf215324-bib-0049","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1186\/1471-2105-7-442","article-title":"A simple method to combine multiple molecular biomarkers for dichotomous diagnostic classification","volume":"7","author":"Mamtani","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"2026021804084750700_ehf215324-bib-0050","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2021.102813","article-title":"A review of machine learning in hypertension detection and blood pressure estimation based on clinical and physiological data","volume":"68","author":"Martinez-R\u00edos","year":"2021","journal-title":"Biomed Sig Process Control"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/4\/3028\/66954460\/eschf_12_4_3028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/4\/3028\/66954460\/eschf_12_4_3028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:08:54Z","timestamp":1771405734000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/12\/4\/3028\/8488053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,2]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,6,2]]},"published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.15324","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,6,2]]},"assertion":[{"value":"2024-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}