{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:41:25Z","timestamp":1785213685727,"version":"3.55.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":212,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Deutsche Herzstiftung e.V"},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Myocardial inflammation is increasingly recognized for its association with impaired clinical outcomes in cardiac amyloidosis but a trend towards less invasive diagnosis impedes its detection. The aim of this study was to assess magnetocardiography (MCG) as a potential non-invasive method to diagnose myocardial inflammation in patients with cardiac amyloidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This retrospective proof-of-concept study included 27 patients with cardiac amyloidosis who had undergone MCG and endomyocardial biopsy as part of their diagnostic workup. Immunohistopathological evaluation identified myocardial inflammation in 10 patients (37.0%). Patients with myocardial inflammation had significantly higher magnetocardiography vector (VMCG) values than those without (0.093 [IQR 0.058\u20130.183] vs. 0.052 [IQR 0.039\u20130.073]; P = 0.01). With an area under the curve of 0.785 (95% CI 0.600\u20130.970; P &amp;lt; 0.01), VMCG had significant diagnostic value for myocardial inflammation in cardiac amyloidosis when tested against a non-informative random classifier in receiver operating characteristic analysis. Youden's index identified VMCG \u22650.078 as the optimal cut-off to discriminate between patients with and without myocardial inflammation, yielding a sensitivity of 60.0%, a specificity of 88.2%, a positive predictive value of 75.0% and a negative predictive value of 78.9%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This proof-of-concept study provides initial evidence for the potential of MCG as a non-invasive method to identify myocardial inflammation in patients with cardiac amyloidosis. These findings require validation in larger prospective studies but could substantially contribute to the optimization of personalized management in patients diagnosed with cardiac amyloidosis via non-invasive pathways in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15377","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T06:33:27Z","timestamp":1753166007000},"page":"3755-3760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Magnetocardiography for the Non-Invasive Diagnosis of Myocardial Inflammation in Cardiac Amyloidosis: A Proof-of-Concept Study"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-9754","authenticated-orcid":false,"given":"Maximilian Leo","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9 - Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Suwalski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Wilke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Latinova","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Satilmis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Musigk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9 - Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Mattig","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9 - Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Knebel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9 - Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Messroghli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9 - Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hahn","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9 - Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Vivantes Humboldt-Klinikum, Klinik f\u00fcr Innere Medizin - Kardiologie und konservative Intensivmedizin , Berlin ,","place":["Germany"]},{"name":"Department of Neurology and Experimental Neurology, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Spethmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9 - Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Heidecker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t Zu Berlin , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9 - Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"2026021804183387200_ehf215377-bib-0001","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/ejhf.1695","article-title":"Emerging therapies in transthyretin amyloidosis - a new wave of hope after years of stagnancy?","volume":"22","author":"Muller","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"2026021804183387200_ehf215377-bib-0002","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.124.012146","article-title":"Myocardial inflammation in cardiac transthyretin amyloidosis: prevalence and potential prognostic implications","volume":"18","author":"Muller","year":"2025","journal-title":"Circ Heart Fail"},{"key":"2026021804183387200_ehf215377-bib-0003","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1002\/ejhf.1039","article-title":"Intramyocardial inflammation predicts adverse outcome in patients with cardiac AL amyloidosis","volume":"20","author":"Siegismund","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026021804183387200_ehf215377-bib-0004","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-74289-5","article-title":"Myocardial inflammatory cells in cardiac amyloidosis","volume":"14","author":"Simon","year":"2024","journal-title":"Sci Rep"},{"key":"2026021804183387200_ehf215377-bib-0005","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-024-02522-2","article-title":"Mechanisms of damage and therapies for cardiac amyloidosis: a role for inflammation?","author":"Bellofatto","year":"2024","journal-title":"Clin Res Cardiol"},{"key":"2026021804183387200_ehf215377-bib-0006","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.jaccao.2021.08.009","article-title":"Temporal trends of wild-type transthyretin amyloid cardiomyopathy in the transthyretin amyloidosis outcomes survey","volume":"3","author":"Nativi-Nicolau","year":"2021","journal-title":"JACC CardioOncol"},{"key":"2026021804183387200_ehf215377-bib-0007","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1161\/CIRCULATIONAHA.116.021612","article-title":"Nonbiopsy diagnosis of cardiac transthyretin amyloidosis","volume":"133","author":"Gillmore","year":"2016","journal-title":"Circulation"},{"key":"2026021804183387200_ehf215377-bib-0008","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1093\/eurheartj\/ehab072","article-title":"Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC working group on myocardial and pericardial diseases","volume":"42","author":"Garcia-Pavia","year":"2021","journal-title":"Eur Heart J"},{"key":"2026021804183387200_ehf215377-bib-0009","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1093\/eurheartj\/ehad213","article-title":"Rediscovery of magnetocardiography for diagnostic screening and monitoring of treatment response in cardiology","volume":"44","author":"Heidecker","year":"2023","journal-title":"Eur Heart J"},{"key":"2026021804183387200_ehf215377-bib-0010","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027619","article-title":"Application of magnetocardiography to screen for inflammatory cardiomyopathy and monitor treatment response","volume":"12","author":"Brala","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"2026021804183387200_ehf215377-bib-0011","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1093\/eurheartj\/eht210","article-title":"Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on myocardial and pericardial diseases","volume":"34","author":"Caforio","year":"2013","journal-title":"Eur Heart J"},{"key":"2026021804183387200_ehf215377-bib-0012","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0002-8703(63)90075-9","article-title":"Detection of the magnetic field of the heart","volume":"66","author":"Baule","year":"1963","journal-title":"Am Heart J"},{"key":"2026021804183387200_ehf215377-bib-0013","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/eurheartj\/14.suppl_e.46","article-title":"Magnetocardiography: supraventricular arrhythmias and preexcitation syndromes","volume":"14","author":"Makijarvi","year":"1993","journal-title":"Eur Heart J"},{"key":"2026021804183387200_ehf215377-bib-0014","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1542-474X.2000.tb00380.x","article-title":"Detection of exercise-induced myocardial ischemia by multichannel magnetocardiography in single vessel coronary artery disease","volume":"5","author":"H\u00e4nninen","year":"2000","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2026021804183387200_ehf215377-bib-0015","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1097\/00004872-200211000-00029","article-title":"Magnetocardiographic indices of left ventricular hypertrophy","volume":"20","author":"Karvonen","year":"2002","journal-title":"J Hypertens"},{"key":"2026021804183387200_ehf215377-bib-0016","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/ejhf.3137","article-title":"Myocardial perfusion in cardiac amyloidosis","volume":"26","author":"Chacko","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"2026021804183387200_ehf215377-bib-0017","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.amjcard.2020.12.024","article-title":"Impact of arrhythmias on hospitalizations in patients with cardiac amyloidosis","volume":"143","author":"Thakkar","year":"2021","journal-title":"Am J Cardiol"},{"key":"2026021804183387200_ehf215377-bib-0018","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1148\/radiol.2015141744","article-title":"Differential myocyte responses in patients with cardiac transthyretin amyloidosis and light-chain amyloidosis: a cardiac MR imaging study","volume":"277","author":"Fontana","year":"2015","journal-title":"Radiology"},{"key":"2026021804183387200_ehf215377-bib-0019","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/j.1542-474x.2005.00634.x","article-title":"Magnetocardiography predicts coronary artery disease in patients with acute chest pain","volume":"10","author":"Park","year":"2005","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2026021804183387200_ehf215377-bib-0020","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00330-010-1985-2","article-title":"Cardiac magnetic resonance imaging in dilated cardiomyopathy in adults--towards identification of myocardial inflammation","volume":"21","author":"Voigt","year":"2011","journal-title":"Eur Radiol"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/5\/3755\/66969752\/eschf_12_5_3755.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/12\/5\/3755\/66969752\/eschf_12_5_3755.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:18:36Z","timestamp":1771406316000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/12\/5\/3755\/8488226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,7,21]]},"published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.15377","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"2025-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}