{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:37:27Z","timestamp":1784205447685,"version":"3.55.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":167,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005970","name":"Deutsche Stiftung f\u00fcr Herzforschung","doi-asserted-by":"publisher","award":["F\/31\/21"],"award-info":[{"award-number":["F\/31\/21"]}],"id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["440662661"],"award-info":[{"award-number":["440662661"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The diagnosis of peripartum cardiomyopathy (PPCM) is often delayed due to the absence of disease-specific biomarkers. Recently, serum proteins\u2014QSOX1, adiponectin (ADIPOQ) and ITIH3\u2014have shown potential for improving diagnostic accuracy, especially when used with NT-proBNP. However, the influence of ethnicity on their expression remains unclear. We aimed to assess whether serum biomarker profiles differ among ethnic groups in a multinational PPCM cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Eighty-two PPCM patients from seven countries in the EURObservational Research Programme (EORP) provided demographic data and serum samples. Ethnicity was self-reported. Proteomic profiling at diagnosis was performed using DIA-based label-free LC\u2013MS, and data were analysed with Spectronaut v15. Ethnic variation was evaluated through principal component analysis (PCA). Participants had a mean age of 30.5 \u00b1 6.7 years; 75% had no hypertension during pregnancy. Median LVEF was 35% (IQR 27.0\u201341.1), with no ethnic differences. Middle Eastern women showed more severe LV dilatation. PCA revealed no significant clustering by ethnicity; PC1 and PC2 explained 15.2% and 12.0% of variance, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>QSOX1, ADIPOQ and ITIH3 exhibited consistent expressions across ethnic groups, supporting their use as universal PPCM biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.15419","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T03:23:53Z","timestamp":1757042633000},"page":"4521-4526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ethnic Differences in Protein Biomarkers of Peripartum Cardiomyopathy: A Proteomic Study on the EORP Cohort"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-9925","authenticated-orcid":false,"given":"Vitaris","family":"Kodogo","sequence":"first","affiliation":[{"name":"Cape Heart Institute, Faculty of Health Sciences, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Internal Medicine, University of Zimbabwe , Harare ,","place":["Zimbabwe"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-0911","authenticated-orcid":false,"given":"Karen","family":"Sliwa","sequence":"additional","affiliation":[{"name":"Cape Heart Institute, Faculty of Health Sciences, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Medicine, Division of Cardiology, Faculty of Health Sciences, Groote Schuur Hospital, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice M.","family":"Jackson","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Al-Farhan","sequence":"additional","affiliation":[{"name":"University of Baghdad College of Medicine, Iraqi Board for Medical Specializations, Baghdad Heart Centre , Baghdad ,","place":["Iraq"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorel","family":"Goland","sequence":"additional","affiliation":[{"name":"Heart Institute, Kaplan Medical Center, Rehovot, affiliated to the Hebrew University , Jerusalem ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Tromp","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health & the National University Health System , Singapore ,","place":["Singapore"]},{"name":"Duke-NUS Medical School , Singapore ,","place":["Singapore"]},{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilu","family":"Karaye","sequence":"additional","affiliation":[{"name":"Department of Medicine, Bayero University , Kano ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[{"name":"APHP, Department of Anesthesiology and Critical Care, Saint Louis Lariboisi\u00e8re Hospitals , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Bauersachs","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Bell","sequence":"additional","affiliation":[{"name":"Centre for Proteomic and Genomic Research , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2023-3026","authenticated-orcid":false,"given":"Julian","family":"Hoevelmann","sequence":"additional","affiliation":[{"name":"Cape Heart Institute, Faculty of Health Sciences, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Internal Medicine III - Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Saarland University , Homburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-4136","authenticated-orcid":false,"given":"Charle","family":"Viljoen","sequence":"additional","affiliation":[{"name":"Cape Heart Institute, Faculty of Health Sciences, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Medicine, Division of Cardiology, Faculty of Health Sciences, Groote Schuur Hospital, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the EurObservational Research Programme in conjunction with the Heart Failure Association of the European Society of Cardiology Study Group on Peripartum 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