{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:21:59Z","timestamp":1792027319836,"version":"4.4.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In Western countries with typically elderly ischaemic acute heart failure patients, predictors and clinical outcome of renal dysfunction and worsening renal function are well described. However, the prevalence, predictors and clinical outcome of renal dysfunction in younger, mainly hypertensive acute heart failure patients from Africa, have not been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>From 1006 patients enrolled in the sub-Saharan Africa Survey of Heart Failure (THESUS-HF), renal function was determined by the estimated glomerular filtration rate using the Modification of Diet in Renal Disease (MDRD) formula. Worsening renal function was defined as an increase in creatinine \u22640.3 mg\/dL (26.5 \u00b5mol\/L) from baseline to day 7\/discharge. The mean (SD) age of the patients was 52.4 (18.2) years, 481 (50.8%) were women and the predominant race was black African [932 of 946 (98.5%)]. Heart failure was most commonly a result of hypertension (n = 363, 39.5%) and only 7.8% had ischaemic heart failure. At hospital admission, 289 patients (30.6%) had an estimated glomerular filtration rate \u226460 ml\/min.1.73m2. Worsening renal function during hospitalization was detected in 53 (9.8 %) of 543 patients with a follow-up creatinine value, and was independently associated with the Western sub-Saharan region, body mass index, and the presence of rales. Worsening renal function was an independent predictor of death or readmission over 60 days [multivariable hazard ratio = 2.06 (1.10, 3.38); P = 0.023] and all-cause death over 180 days [multivariable hazard ratio =1.92 (1.08, 3.38); P = 0.025].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Renal dysfunction is also prevalent in younger non-ischaemic acute heart failure patients in Africa, but worsening renal function is less prevalent and has different predictors compared with Western cohorts. Nevertheless, worsening renal function is strongly and independently related with clinical outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.103","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T11:39:39Z","timestamp":1403609979000},"page":"718-728","source":"Crossref","is-referenced-by-count":12,"title":["Renal Dysfunction in African Patients With Acute Heart Failure"],"prefix":"10.1093","volume":"16","author":[{"given":"Mahmoud U.","family":"Sani","sequence":"first","affiliation":[{"name":"Department of Medicine, Bayero University Kano\/Aminu Kano Teaching Hospital , Kano ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A","family":"Davison","sequence":"additional","affiliation":[{"name":"Momentum Research, Inc. , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad","family":"Cotter","sequence":"additional","affiliation":[{"name":"Momentum Research, Inc. , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Sliwa","sequence":"additional","affiliation":[{"name":"Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town \u00a0","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Edwards","sequence":"additional","affiliation":[{"name":"Momentum Research, Inc. , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licette","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albertino","family":"Damasceno","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Eduardo Mondlane University , Maputo ,","place":["Mozambique"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongani M","family":"Mayosi","sequence":"additional","affiliation":[{"name":"Department of Medicine, GF Jooste and Groote Schuur Hospitals, Hospital, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okechukwu S.","family":"Ogah","sequence":"additional","affiliation":[{"name":"Department of Medicine, University College Hospital Ibadan and Ministry of Health , Abia State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Mondo","sequence":"additional","affiliation":[{"name":"Uganda Heart Institute , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastase","family":"Dzudie","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Douala General Hospital and Buea Faculty of Health Sciences , Douala ,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dike B.","family":"Ojji","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Abuja Teaching Hospital , Abuja ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian A.","family":"Voors","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"2026011921120949700_ejhf103-bib-0001","first-page":"118","article-title":"Pattern of cardiac failure in northern savanna Nigeria","volume":"32","author":"Antony","year":"1980","journal-title":"Trop Geogr Med"},{"key":"2026011921120949700_ejhf103-bib-0002","first-page":"23","article-title":"Clinical and socio demographic aspects of congestive heart failure patients at Kenyatta National Hospital, Nairobi","volume":"76","author":"Oyoo","year":"1999","journal-title":"East Afr Med J"},{"key":"2026011921120949700_ejhf103-bib-0003","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1001\/archinternmed.2012.3310","article-title":"The causes, treatment, and outcome of acute heart failure in 1006 Africans from 9 countries: results of the sub-Saharan Africa Survey of Heart Failure","volume":"172","author":"Damasceno","year":"2012","journal-title":"Arch Internal Med"},{"key":"2026011921120949700_ejhf103-bib-0004","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ahj.2004.08.005","article-title":"ADHERE Scientific Advisory Committee and Investigators. 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