{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:45:52Z","timestamp":1790790352298,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000860","name":"European Society of Cardiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008868","name":"International Society for Heart and Lung Transplantation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008868","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Belgian Fund for Cardiac Surgery"},{"name":"Jacqueline Bernheim prize"},{"name":"Coll\u00e8ge de M\u00e9decine des H\u00f4pitaux de Paris"},{"name":"Ligue Fran\u00e7aise contre la Cardiomyopathie"},{"DOI":"10.13039\/501100013642","name":"Japan Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["FP7-HEALTH-2010-MEDIA"],"award-info":[{"award-number":["FP7-HEALTH-2010-MEDIA"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Congestion is a central feature of acute heart failure (HF) and its assessment is important for clinical decisions (e.g. tailoring decongestive treatments). It remains uncertain whether patients with acute HF with preserved ejection fraction (HFpEF) are comparably congested as in acute HF with reduced EF (HFrEF). This study assessed congestion, right ventricular (RV) and renal dysfunction in acute HFpEF, HFrEF and non-cardiac dyspnoea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We compared echocardiographic and circulating biomarkers of congestion in 146 patients from the MEDIA-DHF study: 101 with acute HF (38 HFpEF, 41 HFrEF, 22 HF with mid-range ejection fraction) and 45 with non-cardiac dyspnoea. Compared with non-cardiac dyspnoea, patients with acute HF had larger left and right atria, higher E\/e', pulmonary artery systolic pressure and inferior vena cava (IVC) diameter at rest, and lower IVC variability (all P\u2009&amp;lt;\u20090.05). Mid-regional pro-atrial natriuretic peptide (MR-proANP) and soluble CD146 (sCD146), but not B-type natriuretic peptide (BNP), correlated with echocardiographic markers of venous congestion. Despite a lower BNP level, patients with HFpEF had similar evidence of venous congestion (enlarged IVC, left and right atria), RV dysfunction (tricuspid annular plane systolic excursion), elevated MR-proANP and sCD146, and renal impairment (estimated glomerular filtration rate; all P\u2009&amp;gt;\u20090.05) compared with HFrEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In acute conditions, HFpEF and HFrEF presented in a comparable state of venous congestion, with similarly altered RV and kidney function, despite higher BNP in HFrEF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1050","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T08:31:15Z","timestamp":1513585875000},"page":"738-747","source":"Crossref","is-referenced-by-count":151,"title":["Acutely Decompensated Heart Failure with Preserved and Reduced Ejection Fraction Present with Comparable Haemodynamic Congestion"],"prefix":"10.1093","volume":"20","author":[{"given":"Lucas N.L.","family":"Van Aelst","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences KU Leuven, Campus Gasthuisberg O&N1 , Leuven ,","place":["Belgium"]},{"name":"Department of Cardiology, H\u00f4pital Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"U942 INSERM, Assistance Publique \u2013 H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Arrigo","sequence":"additional","affiliation":[{"name":"U942 INSERM, Assistance Publique \u2013 H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Division of Cardiology, University Heart Center, University Hospital Zurich , Zurich ,","place":["Switzerland"]},{"name":"Department of Anesthesia and Critical Care, H\u00f4pitaux Universitaires Saint Louis-Lariboisi\u00e8re , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Placido","sequence":"additional","affiliation":[{"name":"U942 INSERM, Assistance Publique \u2013 H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Hospital Santa Maria, Serv Cardiologia I, Lisbon Academic Medical Centre, CCUL , Lisbon ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"U942 INSERM, Assistance Publique \u2013 H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Division of Cardiology, Yokohama City University Medical Center , Minamiku, Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Girerd","sequence":"additional","affiliation":[{"name":"INSERM, Centre d'Investigations Cliniques Plurith\u00e9matique, CHRU de Nancy, Universit\u00e9 de Lorraine, CHRU de Nancy, and F-CRIN INI-CRCT , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[{"name":"INSERM, Centre d'Investigations Cliniques Plurith\u00e9matique, CHRU de Nancy, Universit\u00e9 de Lorraine, CHRU de Nancy, and F-CRIN INI-CRCT , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Manivet","sequence":"additional","affiliation":[{"name":"U942 INSERM, Assistance Publique \u2013 H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Department of Medical Biochemistry and Molecular Biology, H\u00f4pital Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"Biossip Analytical Platform, Center for Biological Resources, Lariboisi\u00e8re Hospital , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[{"name":"INSERM, Centre d'Investigations Cliniques Plurith\u00e9matique, CHRU de Nancy, Universit\u00e9 de Lorraine, CHRU de Nancy, and F-CRIN INI-CRCT , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Badoz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Jean Minjoz , Besan\u00e7on ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malha","family":"Sadoune","sequence":"additional","affiliation":[{"name":"U942 INSERM, Assistance Publique \u2013 H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Launay","sequence":"additional","affiliation":[{"name":"U942 INSERM, Assistance Publique \u2013 H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Department of Medical Biochemistry and Molecular Biology, H\u00f4pital Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"Biossip Analytical Platform, Center for Biological Resources, Lariboisi\u00e8re Hospital , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Gayat","sequence":"additional","affiliation":[{"name":"U942 INSERM, Assistance Publique \u2013 H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Department of Anesthesia and Critical Care, H\u00f4pitaux Universitaires Saint Louis-Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"University Paris Diderot, Sorbonne Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn S.P.","family":"Lam","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore and Duke-National University of Singapore 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