{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:51:06Z","timestamp":1792461066249,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T00:00:00Z","timestamp":1386288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Renal dysfunction is associated with poor cardiovascular outcome. We investigated the relationship of kidney function and long-term cardiovascular outcomes in patients with high risk myocardial infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We studied 27\u2009610 patients from four randomized trials of acute myocardial infarction complicated by heart failure and\/or LV dysfunction (LVEF \u226440%). Two trials excluded patients with serum creatinine \u22652.5\u2009mg\/dL. Patients were grouped by estimated glomerular filtration rate (eGFR) using the four-component Modification of Diet in Renal Disease equation. We used adjusted Cox proportional hazard models to compare mortality and composite cardiovascular events among eGFR groups. Median follow-up was 23\u2009months. The eGFR was approximately normally distributed, with a mean\u2009\u00b1\u2009SD of 69.1\u2009\u00b1\u200920.2\u2009mL\/min\/1.73\u2009m2. Co-morbidities were more prevalent with lower eGFR. The risk of death or composite outcome of cardiovascular death, myocardial infarction, stroke, or heart failure hospitalization increased with declining eGFR. Below 75\u2009mL\/min\/1.73\u2009m2, each 10 unit reduction of eGFR was associated with an adjusted hazard ratio for death of 1.13 (95% confidence interval, 1.11\u20131.15) and composite cardiovascular outcome of 1.09 (95% confidence interval, 1.08\u20131.10). Older patients (\u226575\u2009years) with low LVEF (&amp;lt;30%) had a higher incidence of mortality and adverse cardiovascular events across eGFR categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reduced eGFR is strongly and independently associated with poor cardiovascular outcome following high risk myocardial infarction. In these patients, the combination of older age and poor LV systolic function is associated with increased risk of adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.11","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T06:56:28Z","timestamp":1393829788000},"page":"289-299","source":"Crossref","is-referenced-by-count":19,"title":["The Impact of Kidney Function on Outcomes Following High Risk Myocardial Infarction: Findings from 27\u2009610 Patients"],"prefix":"10.1093","volume":"16","author":[{"given":"George V.","family":"Moukarbel","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Toledo Medical Center , 3000 Arlington Avenue, Toledo, OH 43614 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Fan","family":"Yu","sequence":"additional","affiliation":[{"name":"Statistics Collaborative, Inc. , Washington, DC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Dickstein","sequence":"additional","affiliation":[{"name":"Stavanger University Hospital , Stavanger ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxin (Rachel)","family":"Hou","sequence":"additional","affiliation":[{"name":"Statistics Collaborative, Inc. , Washington, DC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet T.","family":"Wittes","sequence":"additional","affiliation":[{"name":"Statistics Collaborative, Inc. , Washington, DC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J. V.","family":"McMurray","sequence":"additional","affiliation":[{"name":"University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"Pitt","sequence":"additional","affiliation":[{"name":"University of Michigan School of Medicine , Ann Arbor, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[{"name":"Centre d'Investigation Clinique Pierre Drouin, INSERM , CHU de Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,12,6]]},"reference":[{"key":"2026011921112379900_ejhf11-bib-0001","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","article-title":"Prevalence of chronic kidney disease in the United States","volume":"298","author":"Coresh","year":"2007","journal-title":"JAMA"},{"key":"2026011921112379900_ejhf11-bib-0002","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1053\/j.ajkd.2008.07.034","article-title":"Prevalence of CKD in the United States: a sensitivity analysis using the National Health and Nutrition Examination Survey (NHANES) 1999\u20132004","volume":"53","author":"Snyder","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"2026011921112379900_ejhf11-bib-0003","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1471-2458-8-117","article-title":"Prevalence of chronic kidney disease in population-based studies: systematic review","volume":"8","author":"Zhang","year":"2008","journal-title":"BMC Public Health"},{"key":"2026011921112379900_ejhf11-bib-0004","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1161\/01.HYP.0000102971.85504.7c","article-title":"Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention","volume":"42","author":"Sarnak","year":"2003","journal-title":"Hypertension"},{"key":"2026011921112379900_ejhf11-bib-0005","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/aje\/kwn033","article-title":"Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US population","volume":"167","author":"Astor","year":"2008","journal-title":"Am J Epidemiol"},{"key":"2026011921112379900_ejhf11-bib-0006","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0735-1097(02)02663-3","article-title":"Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community","volume":"41","author":"Manjunath","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2026011921112379900_ejhf11-bib-0007","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/eurheartj\/ehi880","article-title":"Chronic kidney disease and risk of incident myocardial infarction and all-cause and cardiovascular disease mortality in middle-aged men and women from the general population","volume":"27","author":"Meisinger","year":"2006","journal-title":"Eur Heart J"},{"issue":"Suppl 1","key":"2026011921112379900_ejhf11-bib-0008","first-page":"S1","article-title":"National Kidney Foundation. 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