{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:56:34Z","timestamp":1790650594269,"version":"4.1.0"},"reference-count":132,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Heart Failure Association of the European Society of Cardiology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heart failure (HF) is a complex clinical syndrome with multiple interactions between the failing myocardium and cerebral (dys-)functions. Bi-directional feedback interactions between the heart and the brain are inherent in the pathophysiology of HF: (i) the impaired cardiac function affects cerebral structure and functional capacity, and (ii) neuronal signals impact on the cardiovascular continuum. These interactions contribute to the symptomatic presentation of HF patients and affect many co-morbidities of HF. Moreover, neuro-cardiac feedback signals significantly promote aggravation and further progression of HF and are causal in the poor prognosis of HF. The diversity and complexity of heart and brain interactions make it difficult to develop a comprehensive overview. In this paper a systematic approach is proposed to develop a comprehensive atlas of related conditions, signals and disease mechanisms of the interactions between the heart and the brain in HF. The proposed taxonomy is based on pathophysiological principles. Impaired perfusion of the brain may represent one major category, with acute (cardio-embolic) or chronic (haemodynamic failure) low perfusion being sub-categories with mostly different consequences (i.e. ischaemic stroke or cognitive impairment, respectively). Further categories include impairment of higher cortical function (mood, cognition), of brain stem function (sympathetic over-activation, neuro-cardiac reflexes). Treatment-related interactions could be categorized as medical, interventional and device-related interactions. Also interactions due to specific diseases are categorized. A methodical approach to categorize the interdependency of heart and brain may help to integrate individual research areas into an overall picture.<\/jats:p>","DOI":"10.1002\/ejhf.1100","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T02:17:02Z","timestamp":1514341022000},"page":"199-215","source":"Crossref","is-referenced-by-count":182,"title":["Heart and Brain Interaction in Patients with Heart Failure: Overview and Proposal for a Taxonomy. 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Birhan","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Cumhuriyet University , Sivas ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Metabolism, Department of Cardiology (CVK), Deutsches Zentrum f\u00fcr Herz-Kreislauf-Forschung (DZHK), Charit\u00e9 - Universit\u00e4tsmedizin Berlin \u00a0","place":["Germany"]},{"name":"Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charit\u00e9 - Universit\u00e4tsmedizin Berlin \u00a0","place":["Germany"]},{"name":"Department of Cardiology and Pneumology, University of G\u00f6ttingen Medical Center , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Attikon University Hospital, National & Kapodistrian University of Athens , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Seferovic","sequence":"additional","affiliation":[{"name":"University of Belgrade, Faculty of Medicine, Clinical Center of Serbia , Belgrade ,","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.S.","family":"Coats","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, IRCCS San Raffaele Pisana , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[{"name":"University Heart Center, Department of Cardiology, University Hospital Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,27]]},"reference":[{"key":"2026080800364767000_ejhf1100-bib-0001","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5694\/j.1326-5377.2008.tb01919.x","article-title":"Prevalence and patterns of multimorbidity in Australia","volume":"189","author":"Britt","year":"2008","journal-title":"Med J Aust"},{"key":"2026080800364767000_ejhf1100-bib-0002","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.jacc.2017.01.022","article-title":"Heart failure-induced brain injury","volume":"69","author":"Havakuk","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2026080800364767000_ejhf1100-bib-0003","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1093\/eurheartj\/ehw334","article-title":"Cardiovascular disease in Europe: epidemiological update 2016","volume":"37","author":"Townsend","year":"2016","journal-title":"Eur Heart J"},{"key":"2026080800364767000_ejhf1100-bib-0004","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000441106","article-title":"Roth GA; GBD 2013 Stroke Panel Experts Group. 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