{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:42:20Z","timestamp":1790264540318,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to assess safety and outcomes of patients, 2\u2009years after implantation with the HeartMate 3 Left Ventricular Assist System.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This study included 50 adults with New York Heart Association (NYHA) class IIIB or IV symptoms or American College of Cardiology\/American Heart Association stage D heart failure with an ejection fraction \u226425% and a cardiac index \u22642.2\u2009L\/min\/m2 without inotropes, or inotrope-dependent with optimal medical management, or listed for heart transplant. The median duration of left ventricular assist device support was 694\u2009days (range: 19\u2013833\u2009days). At baseline, cardiac index was 1.8\u2009\u00b10.5\u2009L\/min\/m2, 58% of patients were receiving inotropes, and 92% were INTERMACS profiles 2\u20134. At 2\u2009years, Kaplan\u2013Meier survival was 74\u2009\u00b16%, 5 (10%) patients were transplanted, and 32 patients (64%) remain with support. Adverse event rates include bleeding requiring surgery (16%), gastrointestinal bleeding (20%), driveline infection (24%), ischaemic stroke (16%), haemorrhagic stroke (8%), right heart failure (14%), and outflow graft thrombosis (2%). Notably, no haemolysis, pump thrombosis, or pump malfunction events occurred. At 2\u2009years, 47% of patients remained in NYHA class I and 41% in NYHA class II (P\u2009&amp;lt;0.0001). From baseline to 2\u2009years, the mean six-minute walk distance increased from 239\u2009m to 347\u2009m (P\u2009&amp;lt;0.0001), and the mean EQ-5D quality of life score improved from 48.2 to 70.6 (P\u2009&amp;lt;\u20090.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Two years post-HeartMate 3 implantation, results show expected and acceptable survival, enhanced haemocompatibility, improved patient functional status and quality of life. This corroborates the success of HeartMate 3 since its first-in-man implantation case in Germany.<\/jats:p>\n                    <jats:p>ClinicalTrials.gov: NCT02170363.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1284","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T10:11:17Z","timestamp":1532686277000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Long-Term Evaluation of a Fully Magnetically Levitated Circulatory Support Device for Advanced Heart Failure\u2014Two-Year Results from The Heartmate 3\u2009CE Mark Study"],"prefix":"10.1093","volume":"21","author":[{"given":"Jan D.","family":"Schmitto","sequence":"first","affiliation":[{"name":"Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriy","family":"Pya","sequence":"additional","affiliation":[{"name":"National 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