{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:05:44Z","timestamp":1791943544033,"version":"4.3.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"UK National Institute for Health Research","doi-asserted-by":"crossref","award":["HTA 15\/80\/30"],"award-info":[{"award-number":["HTA 15\/80\/30"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000272","name":"UK National Institute for Health Research","doi-asserted-by":"crossref","award":["HTA 15\/80\/30"],"award-info":[{"award-number":["HTA 15\/80\/30"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To undertake an individual patient data (IPD) meta-analysis to assess the impact of exercise-based cardiac rehabilitation (ExCR) in patients with heart failure (HF) on mortality and hospitalisation, and differential effects of ExCR according to patient characteristics: age, sex, ethnicity, New York Heart Association functional class, ischaemic aetiology, ejection fraction, and exercise capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Randomised trials of exercise training for at least 3 weeks compared with no exercise control with 6-month follow-up or longer, providing IPD time to event on mortality or hospitalisation (all-cause or HF-specific). IPD were combined into a single dataset. We used Cox proportional hazards models to investigate the effect of ExCR and the interactions between ExCR and participant characteristics. We used both two-stage random effects and one-stage fixed effect models. IPD were obtained from 18 trials including 3912 patients with HF with reduced ejection fraction. Compared to control, there was no statistically significant difference in pooled time to event estimates in favour of ExCR although confidence intervals (CIs) were wide [all-cause mortality: hazard ratio (HR) 0.83, 95% CI 0.67\u20131.04; HF-specific mortality: HR 0.84, 95% CI 0.49\u20131.46; all-cause hospitalisation: HR 0.90, 95% CI 0.76\u20131.06; and HF-specific hospitalisation: HR 0.98, 95% CI 0.72\u20131.35]. No strong evidence was found of differential intervention effects across patient characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exercise-based cardiac rehabilitation did not have a significant effect on the risk of mortality and hospitalisation in HF with reduced ejection fraction. However, uncertainty around effect estimates precludes drawing definitive conclusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1311","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T08:20:04Z","timestamp":1537950004000},"page":"1735-1743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Impact of Exercise-Based Cardiac Rehabilitation in Patients with Heart Failure (ExTraMATCH II) on Mortality and Hospitalisation: An Individual Patient Data Meta-Analysis of Randomised Trials"],"prefix":"10.1093","volume":"20","author":[{"given":"Rod S.","family":"Taylor","sequence":"first","affiliation":[{"name":"Institute of Health Research, University of Exeter Medical School , Exeter ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Walker","sequence":"additional","affiliation":[{"name":"Institute of Health Research, University of Exeter Medical School , Exeter ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Smart","sequence":"additional","affiliation":[{"name":"University of New England , Armidale ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo F.","family":"Piepoli","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Guglielmo da Saliceto Hospital , Piacenza ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona C.","family":"Warren","sequence":"additional","affiliation":[{"name":"Institute of Health Research, University of Exeter Medical School , Exeter ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Ciani","sequence":"additional","affiliation":[{"name":"Institute of Health Research, University of Exeter Medical School , Exeter ,","place":["UK"]},{"name":"Centre for Research on Health and Social Care Management, Bocconi University , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute , North Carolina, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Whellan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sidney Kimmel Medical College , Philadelphia, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Keteyian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Henry Ford Hospital , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Coats","sequence":"additional","affiliation":[{"name":"IRCCS, San Raffaele Pisana , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos H.","family":"Davos","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasnain M.","family":"Dalal","sequence":"additional","affiliation":[{"name":"Institute of Health Research, University of Exeter Medical School , Exeter ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Dracup","sequence":"additional","affiliation":[{"name":"School of Nursing, University of California San Francisco , CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Evangelista","sequence":"additional","affiliation":[{"name":"University of California , Irvine, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Jolly","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Research, University of Birmingham \u00a0","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Myers","sequence":"additional","affiliation":[{"name":"Palo Alto Health Care System\/Stanford University , Palo Alto, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"McKelvie","sequence":"additional","affiliation":[{"name":"St. Joseph's Health Care Centre , London ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta B.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Division of Medicine, Oslo University Hospital and Faculty of Health Sciences, Oslo Metropolitan University \u00a0","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Passino","sequence":"additional","affiliation":[{"name":"Fondazione G. Monasterio and Scuola Superiore Sant'Anna , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles D.","family":"Witham","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Dundee , Dundee ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Y.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Dorthe O.","family":"Zwisler","sequence":"additional","affiliation":[{"name":"National Knowledge Centre for Rehabilitation and Palliative Care, University Hospital Odense and University of Southern Denmark , Nyborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"2026011721261649200_ejhf1311-bib-0001","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/HJR.0b013e328334f42d","article-title":"Cardiac rehabilitation in Europe: results from the European Cardiac Rehabilitation Inventory Survey","volume":"17","author":"Bjarnason-Wehrens","year":"2010","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"2026011721261649200_ejhf1311-bib-0002","volume-title":"The BACPR standards and core components for cardiovascular disease prevention and rehabilitation 2017","author":"British Association for Cardiovascular Prevention and Rehabilitation (BACPR)","year":"2018","edition":"3rd edition"},{"key":"2026011721261649200_ejhf1311-bib-0003","article-title":"Cardiac rehabilitation","volume":"351","author":"Dalal","year":"2015","journal-title":"BMJ"},{"key":"2026011721261649200_ejhf1311-bib-0004","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1177\/2047487314559853","article-title":"Exercise-based cardiac rehabilitation in patients with heart failure: a meta-analysis of randomised controlled trials between 1999 and 2013","volume":"22","author":"Lewinter","year":"2015","journal-title":"Eur J Prev Cardiol"},{"key":"2026011721261649200_ejhf1311-bib-0005","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.amjcard.2013.01.303","article-title":"Meta-analysis of aerobic interval training on exercise capacity and systolic function in patients with heart failure and reduced ejection fractions","volume":"111","author":"Haykowsky","year":"2013","journal-title":"Am J Cardiol"},{"key":"2026011721261649200_ejhf1311-bib-0006","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.amjmed.2003.11.033","article-title":"Exercise training for patients with heart failure: a systematic review of factors that improve mortality and morbidity","volume":"116","author":"Smart","year":"2004","journal-title":"Am J Med"},{"key":"2026011721261649200_ejhf1311-bib-0007","article-title":"Exercise-based rehabilitation for heart failure","volume":"4","author":"Taylor","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"2026011721261649200_ejhf1311-bib-0008","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/bmj.328.7441.711-b","article-title":"Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH)","volume":"328","author":"Piepoli","year":"2004","journal-title":"BMJ"},{"key":"2026011721261649200_ejhf1311-bib-0009","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/jama.2009.454","article-title":"Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial","volume":"301","author":"O'Connor","year":"2009","journal-title":"JAMA"},{"key":"2026011721261649200_ejhf1311-bib-0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001855","article-title":"Individual participant data (IPD) meta-analyses of randomised controlled trials: guidance on their use","volume":"12","author":"Tierney","year":"2015","journal-title":"PLoS Med"},{"key":"2026011721261649200_ejhf1311-bib-0011","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1001\/jama.2015.3656","article-title":"Preferred Reporting Items for Systematic Review and Meta-Analyses of Individual Participant Data: the PRISMA-IPD statement","volume":"313","author":"Stewart","year":"2015","journal-title":"JAMA"},{"key":"2026011721261649200_ejhf1311-bib-0012","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ijcard.2014.04.203","article-title":"Exercise training for chronic heart failure (ExTraMATCH II): protocol for an individual participant data meta-analysis","volume":"174","author":"Taylor","year":"2014","journal-title":"Int J Cardiol"},{"key":"2026011721261649200_ejhf1311-bib-0013","article-title":"Exercise training for chronic heart failure (ExTraMATCH II): protocol for an individual participant data meta-analysis","author":"Taylor","journal-title":"PROSPERO international prospective register of systematic reviews 2014"},{"key":"2026011721261649200_ejhf1311-bib-0014","doi-asserted-by":"crossref","first-page":"c221","DOI":"10.1136\/bmj.c221","article-title":"Meta-analysis of individual participant data: rationale, conduct, and reporting","volume":"340","author":"Riley","year":"2010","journal-title":"BMJ"},{"key":"2026011721261649200_ejhf1311-bib-0015","doi-asserted-by":"crossref","first-page":"d7762","DOI":"10.1136\/bmj.d7762","article-title":"Assessment of publication bias, selection bias, and unavailable data in meta-analyses using individual participant data: a database survey","volume":"344","author":"Ahmed","year":"2012","journal-title":"BMJ"},{"key":"2026011721261649200_ejhf1311-bib-0016","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/XEB.0000000000000020","article-title":"Validation of a new tool for the assessment of study quality and reporting in exercise training trials: TESTEX","volume":"13","author":"Smart","year":"2015","journal-title":"Int J Evid Based Healthc"},{"key":"2026011721261649200_ejhf1311-bib-0017","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"2026011721261649200_ejhf1311-bib-0018","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"2026011721261649200_ejhf1311-bib-0019","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"2026011721261649200_ejhf1311-bib-0020","volume-title":"An Introduction to Survival Analysis Using Stata","author":"Cleves","year":"2016","edition":"3rd edition"},{"key":"2026011721261649200_ejhf1311-bib-0021","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1002\/sim.3165","article-title":"Meta-analysis of continuous outcomes combining individual patient data and aggregate data","volume":"27","author":"Riley","year":"2008","journal-title":"Stat Med"},{"key":"2026011721261649200_ejhf1311-bib-0022","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/01.CIR.99.9.1173","article-title":"Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome","volume":"99","author":"Belardinelli","year":"1999","journal-title":"Circulation"},{"key":"2026011721261649200_ejhf1311-bib-0023","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.283.23.3095","article-title":"Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: a randomized trial","volume":"283","author":"Hambrecht","year":"2000","journal-title":"JAMA"},{"key":"2026011721261649200_ejhf1311-bib-0024","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1067\/mhj.2002.123310","article-title":"Effects of exercise training in patients with heart failure: the Exercise Rehabilitation Trial (EXERT)","volume":"144","author":"McKelvie","year":"2002","journal-title":"Am Heart J"},{"key":"2026011721261649200_ejhf1311-bib-0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0167-5273(00)00383-1","article-title":"Effects on quality of life, symptoms and daily activity 6 months after termination of an exercise training programme in heart failure patients","volume":"77","author":"Willenheimer","year":"2001","journal-title":"Int J Cardiol"},{"issue":"Suppl","key":"2026011721261649200_ejhf1311-bib-0026","first-page":"647","article-title":"Multidisciplinary non-pharmacological intervention prevents hospitalization, improves morbidity rates and functional status in patients with congestive heart failure [abstract]","volume":"18","author":"Zanelli","year":"1997","journal-title":"Eur Heart J"},{"key":"2026011721261649200_ejhf1311-bib-0027","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1053\/euhj.1999.1485","article-title":"Safety and effects of physical training in chronic heart failure. Results of the Chronic Heart Failure and Graded Exercise study (CHANGE)","volume":"20","author":"Wielenga","year":"1999","journal-title":"Eur Heart J"},{"key":"2026011721261649200_ejhf1311-bib-0028","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/HJR.0b013e328334ea56","article-title":"Can a heart failure-specific cardiac rehabilitation program decrease hospitalizations and improve outcomes in high-risk patients?","volume":"17","author":"Davidson","year":"2010","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"2026011721261649200_ejhf1311-bib-0029","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejheart.2004.10.004","article-title":"Randomised controlled trial of cardiac rehabilitation in elderly patients with heart failure","volume":"7","author":"Austin","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"2026011721261649200_ejhf1311-bib-0030","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/HJR.0b013e3280114f12","article-title":"Physical training in patients with chronic heart failure of ischemic origin: effect on exercise capacity and left ventricular remodeling","volume":"14","author":"Klecha","year":"2007","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"2026011721261649200_ejhf1311-bib-0031","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0735-1097(97)82540-5","article-title":"Effect of high intensity exercise training on central hemodynamic responses to exercise in men with reduced left ventricular function","volume":"29","author":"Dubach","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"2026011721261649200_ejhf1311-bib-0032","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/0269215507079097","article-title":"Exercise capacity, physical activity patterns and outcomes six years after cardiac rehabilitation in patients with heart failure","volume":"21","author":"Mueller","year":"2007","journal-title":"Clin Rehabil"},{"key":"2026011721261649200_ejhf1311-bib-0033","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jpsychores.2010.01.013","article-title":"Combined exercise and cognitive behavioral therapy improves outcomes in patients with heart failure","volume":"69","author":"Gary","year":"2010","journal-title":"J Psychosom Res"},{"key":"2026011721261649200_ejhf1311-bib-0034","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2014-000163","article-title":"Exercise-based rehabilitation for heart failure: systematic review and meta-analysis","volume":"2","author":"Sagar","year":"2015","journal-title":"Open Heart"},{"key":"2026011721261649200_ejhf1311-bib-0035","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/sim.1187","article-title":"How should meta-regression analyses be undertaken and interpreted?","volume":"21","author":"Thompson","year":"2002","journal-title":"Stat Med"},{"key":"2026011721261649200_ejhf1311-bib-0036","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ahj.2013.06.002","article-title":"Race, exercise training, and outcomes in chronic heart failure: findings from Heart Failure-a Controlled Trial Investigating Outcomes in Exercise TraiNing (HF-ACTION)","volume":"166","author":"Mentz","year":"2013","journal-title":"Am Heart J"},{"key":"2026011721261649200_ejhf1311-bib-0037","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1749-6632.1993.tb26345.x","article-title":"The Cochrane Collaboration: preparing, maintaining, and disseminating systematic reviews of the effects of health care","volume":"703","author":"Chalmers","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"2026011721261649200_ejhf1311-bib-0038","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/eurjhf\/hft095","article-title":"Clinical outcome endpoints in heart failure trials: a European Society of Cardiology Heart Failure Association consensus document","volume":"15","author":"Zannad","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"2026011721261649200_ejhf1311-bib-0039","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/j.jacc.2012.08.958","article-title":"Relation between volume of exercise and clinical outcomes in patients with heart failure","volume":"60","author":"Keteyian","year":"2012","journal-title":"J Am Coll Cardiol"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejhf.1311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.1311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.1311","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/20\/12\/1735\/66267864\/eurjhf_20_12_1735.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/20\/12\/1735\/66267864\/eurjhf_20_12_1735.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:28:30Z","timestamp":1768703310000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/20\/12\/1735\/8414507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,26]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,9,26]]},"published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ejhf.1311","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,12]]},"published":{"date-parts":[[2018,9,26]]},"assertion":[{"value":"2018-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}