{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:08:45Z","timestamp":1791446925303,"version":"4.3.3"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":2657,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019040","name":"Respicardia, Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019040","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Respicardia, Inc"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The presence of central sleep apnoea (CSA) is associated with poor prognosis in patients with heart failure (HF). The aim of this analysis was to evaluate if using phrenic nerve stimulation to treat CSA in patients with CSA and HF was associated with changes in HF-specific metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>All patients randomized in the remed\u0113 System Pivotal Trial and identified at baseline with HF were included (n = 96). Effectiveness data from treatment and former control groups were pooled based on months since therapy activation. Changes from baseline to 6 and 12 months in sleep metrics, Epworth Sleepiness Scale, patient global assessment health-related quality of life, Minnesota Living with Heart Failure Questionnaire (MLHFQ), and echocardiographic parameters are reported. HF hospitalization, cardiovascular death, and the composite of HF hospitalization or cardiovascular death within 6 months are reported by the original randomized group assignment for safety assessment. Sleep metrics and quality of life improved from baseline to 6 and 12 months. At 12 months, MLHFQ scores changed by \u20136.8 \u00b1 20.0 (P = 0.005). The 6-month rate of HF hospitalization was 4.7% in treatment patients (standard error = 3.3) and 17.0% in control patients (standard error = 5.5) (P = 0.065). Reported adverse events were as expected for a transvenous implantable system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Phrenic nerve stimulation reduces CSA severity in patients with HF. In parallel, this CSA treatment was associated with benefits on HF quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1312","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T10:33:15Z","timestamp":1539167595000},"page":"1746-1754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Phrenic Nerve Stimulation to Treat Patients with Central Sleep Apnoea and Heart Failure"],"prefix":"10.1093","volume":"20","author":[{"given":"Maria Rosa","family":"Costanzo","sequence":"first","affiliation":[{"name":"Advocate Heart Institute , Naperville, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Medical University, Military Hospital , Wroclaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Coats","sequence":"additional","affiliation":[{"name":"University of Warwick , Coventry ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh","family":"Javaheri","sequence":"additional","affiliation":[{"name":"Bethesda North Hospital , Cincinnati, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Augostini","sequence":"additional","affiliation":[{"name":"The Ohio State University , Columbus, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee R.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Holcomb","sequence":"additional","affiliation":[{"name":"Independent Biostatistician , Minneapolis, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kao","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute , Kansas City, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami N.","family":"Khayat","sequence":"additional","affiliation":[{"name":"The Ohio State University , Columbus, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Bad Oeynhausen Heart and Diabetes Center , Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Stellbrink","sequence":"additional","affiliation":[{"name":"Bielefeld Medical Center , Bielefeld ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McKane","sequence":"additional","affiliation":[{"name":"Respicardia, Inc. , Minnetonka, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Abraham","sequence":"additional","affiliation":[{"name":"The Ohio State University , Columbus, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the remed\u0113\u00ae System Pivotal Trial Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"2026011721255862900_ejhf1312-bib-0001","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jacc.2014.10.025","article-title":"Mechanisms and clinical consequences of untreated central sleep apnea in heart failure","volume":"65","author":"Costanzo","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2026011721255862900_ejhf1312-bib-0002","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1161\/01.CIR.97.21.2154","article-title":"Sleep apnea in 81 ambulatory male patients with stable heart failure. 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