{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:11:14Z","timestamp":1782141074133,"version":"3.54.5"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Health Services Executive"},{"name":"Heartbeat Trust Registered Charity No. CHY 15398"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Heart failure (HF) patients may be at risk of prescription of potentially inappropriate medicines (PIMs) yet no disease-specific list is available to assess PIM use in this population. A Consensus Potentially Inappropriate Medicines in Heart Failure (PIMHF) list was developed, assessed, and compared with an established, general tool in an ambulatory HF population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The Consensus PIMHF list was compiled using modified Delphi methodology with a multidisciplinary team. The list consisted of 11 items. The medication profile of 350 patients was assessed. The association of a Consensus PIMHF item use over a median follow-up period of 1.8 (interquartile range 1.3\u20132.1) years with the primary endpoint of death, acute hospitalization, or unscheduled outpatient visit was examined. Fifty-one patients (14.6%) were prescribed \u22651 Consensus PIMHF item. In univariable analysis, patients prescribed \u22651 Consensus PIMHF item were 58% more likely to experience the primary endpoint than those with none [95% confidence interval (CI) 1.02\u20132.45]. When adjusted for age, sex, and HF severity, this difference remained [hazard ratio (HR) 1.88, 95% CI 1.16\u20133.06] and these associations were in contrast to the use of a more general tool (HR 1.24, 95% CI 0.83\u20131.84). However, when further adjusted to include co-morbidity score and polypharmacy, there was no association with outcome using either tool (HR 1.40, 95% CI 0.83\u20132.38; HR 1.05, 95% CI 0.69\u20131.60, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Consensus PIMHF list provides the first HF-specific medicines review tool. These results provide some support for more disease-specific tools with limited lists of PIMs to rationalize medicines management in HF. However, more prospective work on the application of these tools in practice is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.132","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T08:06:35Z","timestamp":1407398795000},"page":"915-922","source":"Crossref","is-referenced-by-count":18,"title":["The St Vincent's Potentially Inappropriate Medicines Study: Development of a Disease-Specific Consensus List and its Evaluation in Ambulatory Heart Failure Care"],"prefix":"10.1093","volume":"16","author":[{"given":"Margaret","family":"Bermingham","sequence":"first","affiliation":[{"name":"Heart Failure Unit, St Vincent's University Hospital , Dublin ,","place":["Ireland"]},{"name":"School of Medicine and Medical Science, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ryder","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, St Vincent's University Hospital , Dublin ,","place":["Ireland"]},{"name":"School of Medicine and Medical Science, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronagh","family":"Travers","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, St Vincent's University Hospital , Dublin ,","place":["Ireland"]},{"name":"School of Medicine and Medical Science, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuala","family":"Edwards","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, St Vincent's University Hospital , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Lalor","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, St Vincent's University Hospital , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"Kelly","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, St Vincent's University Hospital , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, St Vincent's University Hospital , Dublin ,","place":["Ireland"]},{"name":"School of Medicine and Medical Science, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"O'Hanlon","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, St Vincent's University Hospital , Dublin ,","place":["Ireland"]},{"name":"Centre for Cardiovascular Magnetic Resonance, Blackrock Clinic, Co. , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"McDonald","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, St Vincent's University Hospital , Dublin ,","place":["Ireland"]},{"name":"School of Medicine and Medical Science, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ledwidge","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, St Vincent's University Hospital , Dublin ,","place":["Ireland"]},{"name":"School of Medicine and Medical Science, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"2026011921122993200_ejhf132-bib-0001","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejheart.2003.08.003","article-title":"Specialist care of heart failure improves appropriate pharmacotherapy at the expense of greater polypharmacy and drug-interactions","volume":"6","author":"Ledwidge","year":"2004","journal-title":"Eur J Heart Fail"},{"key":"2026011921122993200_ejhf132-bib-0002","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/eurjhf\/hfs105","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. 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