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For 1538 patients of the trial (median age 73\u2009years, interquartile range 64\u201378\u2009years, 30% female), baseline biomarkers were used to select subpopulations recommended for RPM with various safety endpoints (100%, 98%, 95% sensitivity), and efficacy of RPM was assessed. Both biomarkers were strongly associated with events. The primary endpoint of lost days increased from 1.0% (1.4%) in the lowest to 17.3% (17.6%) in the highest quintile of NT-proBNP (MR-proADM). After combining biomarkers to identify patients recommended for RPM with 95% sensitivity, in the most efficient scenario (excluding 27% of patients; NT-proBNP &amp;lt;\u2009413.7\u2009pg\/mL and MR-proADM &amp;lt;\u20090.75\u2009nmol\/L), the effect of RPM on patients was highly similar to the original trial (ratio of lost days: 0.78, hazard ratio for all-cause death: 0.68). Number needed to treat for all-cause death was lowered from 28 to 21. Rates of emergencies and telemedical efforts were significantly lower among patients not recommended for RPM. Biomarker guidance would have saved about 150\u2009h effort\/year per 100 patients of the eligible population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combined use of MR-proADM and NT-proBNP may allow safe, more precise, effective and cost-saving allocation of patients with heart failure to RPM and warrants further prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1530","type":"journal-article","created":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T00:31:52Z","timestamp":1558830712000},"page":"1445-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Biomarker Guidance Allows a More Personalized Allocation of Patients for Remote Patient Management in Heart Failure: Results from the TIM-HF2 Trial"],"prefix":"10.1093","volume":"21","author":[{"given":"Martin","family":"M\u00f6ckel","sequence":"first","affiliation":[{"name":"Division of Emergency and Acute Medicine, Cardiovascular Process Research, Campus Mitte and Virchow, Charit\u00e9 - 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