{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:18:29Z","timestamp":1776298709395,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008246","name":"School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008993","name":"University of Zagreb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008993","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008246","name":"Tufts University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008993","name":"Sveu\u010dili\u0161te u Zagrebu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare characteristics of left ventricular assist device (LVAD) recipients receiving a cardiac implantable electronic device (CIED) with a defibrillator component (implantable cardioverter-defibrillator and cardiac resynchronization therapy with defibrillation, CIED-D) vs. those without one, and to assess whether carrying such a device contiguously with an LVAD is associated with outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Overall, 448 patients were analysed (mean age 52\u2009\u00b1\u200913\u2009years, 82% male) in the multicentre European PCHF-VAD registry. To account for all active CIED-Ds during ongoing LVAD treatment, outcome analyses were performed by a time-varying analysis with active CIED-D status post-LVAD as the time-varying covariate. At the time of LVAD implantation, 235 patients (52%) had an active CIED-D. Median time on LVAD support was 1.1\u2009years (interquartile range 0.5\u20132.0 years). A reduction of 36% in the risk of all-cause mortality was observed in patients with an active CIED-D [hazard ratio (HR) 0.64, 95% confidence interval (CI) 0.46\u20130.91; P = 0.012), increasing to 41% after<\/jats:p>\n                    <jats:p>adjustment for baseline covariates (HR 0.59, 95% CI 0.40\u20130.87; P = 0.008) and 39% after propensity score adjustment (HR 0.61, 95% CI 0.39\u20130.94; P = 0.027). Other than CIED-D, age, LVAD implant as redo surgery, number of ventricular arrhythmia episodes and use of vasopressors pre-LVAD were remaining significant risk factors of all-cause mortality. Incident ventricular arrhythmias post-LVAD portended a 2.4-fold and 2.6-fold increased risk of all-cause and cardiovascular death, respectively; carrying an active CIED-D remained associated with a 47% and 43% reduction in these events, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In an analysis accounting for all active CIED-Ds, including those implanted during LVAD support, carrying such a device was associated with significantly better survival during LVAD support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1568","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T23:54:30Z","timestamp":1565740470000},"page":"1129-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Cardiac Implantable Electronic Devices with a Defibrillator Component and All-Cause Mortality in Left Ventricular Assist Device Carriers: Results from the PCHF-VAD Registry"],"prefix":"10.1093","volume":"21","author":[{"given":"Maja","family":"Cikes","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, University of Zagreb School of Medicine and University Hospital Centre Zagreb , Zagreb ,","place":["Croatia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Jakus","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University of Zagreb School of Medicine and University Hospital Centre Zagreb , Zagreb ,","place":["Croatia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Claggett","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasper J.","family":"Brugts","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus MC, University Medical Center Rotterdam , Rotterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Timmermans","sequence":"additional","affiliation":[{"name":"University Hospital Leuven , Leuven ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Catherine","family":"Pouleur","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc , Brussels ,","place":["Belgium"]},{"name":"P\u00f4le de Recherche Cardiovasculaire (CARD) Institut de Recherche Exp\u00e9rimentale et Clinique (IREC) Universit\u00e9 Catholique de Louvain , Louvain ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Rubis","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Diseases Krakow, Jagiellonian University Medical College, John Paul II Hospital , Krakow ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeline M.","family":"Van Craenenbroeck","sequence":"additional","affiliation":[{"name":"Antwerp University Hospital , Antwerp ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edvinas","family":"Gaizauskas","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University , Vilnius ,","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Grundmann","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Heart Center Freiburg University, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Paolillo","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Federico II University of Naples , Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Barge-Caballero","sequence":"additional","affiliation":[{"name":"INIBIC, CIBERCV, Complejo Hospitalario Universitario de A Coru\u00f1a , A Coru\u00f1a ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"D'Amario","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. 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Cliniques Universitaires St. Luc , Brussels ,","place":["Belgium"]},{"name":"P\u00f4le de Recherche Cardiovasculaire (CARD) Institut de Recherche Exp\u00e9rimentale et Clinique (IREC) Universit\u00e9 Catholique de Louvain , Louvain ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Houard","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc , Brussels ,","place":["Belgium"]},{"name":"P\u00f4le de Recherche Cardiovasculaire (CARD) Institut de Recherche Exp\u00e9rimentale et Clinique (IREC) Universit\u00e9 Catholique de Louvain , Louvain ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Holcman","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Diseases Krakow, Jagiellonian University Medical College, John Paul II Hospital , Krakow 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