{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:32:14Z","timestamp":1775277134447,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Exercise oscillatory ventilation (EOV) is a pivotal cardiopulmonary exercise test parameter for the prognostic evaluation of patients with chronic heart failure (HF). It has been described in patients with HF with reduced ejection fraction (&amp;lt;40%, HFrEF) and with HF with preserved ejection fraction (&amp;gt;50%, HFpEF), but no data are available for patients with HF with mid-range ejection fraction (40\u201349%, HFmrEF). The aim of the study was to evaluate the prognostic role of EOV in HFmrEF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed 1239 patients with HFmrEF and 4482 patients with HFrEF, enrolled in the MECKI score database, with a 2-year follow-up. The study endpoint was the composite of cardiovascular death, urgent heart transplant, and ventricular assist device implantation. We identified EOV in 968 cases (16% and 17% of cases in HFmrEF and HFrEF, respectively). HFrEF EOV+ patients were significantly older, and their parameters suggested a more severe HF than HFrEF EOV\u2212 patients. A similar behaviour was found in HFmrEF EOV+ vs. EOV\u2212 patients. Kaplan\u2013Meier analysis, irrespective of ejection fraction, showed that EOV is associated with a worse survival, and that patients with HFrEF and HFmrEF EOV+ had a significantly worse outcome than the EOV\u2212 of the same ejection fraction groups. EOV-associated survival differences in HFmrEF patients started after 18\u2009months of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exercise oscillatory ventilation has a similar prevalence and ominous prognostic value in both HFmrEF and HFrEF patients, indicating a group of patients in need of a more intensive follow-up and a more aggressive therapy. In HFmrEF, the survival curves between EOV+ and EOV\u2212 patients diverged only after 18\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1595","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T21:24:27Z","timestamp":1574976267000},"page":"1586-1595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Exercise Oscillatory Ventilation and Prognosis in Heart Failure Patients with Reduced and Mid-Range Ejection Fraction"],"prefix":"10.1093","volume":"21","author":[{"given":"Sara","family":"Rovai","sequence":"first","affiliation":[{"name":"U.O Scompenso, Centro Cardiologico Monzino, IRCCS , Milan ,","place":["Italy"]},{"name":"Sport and Exercise Medicine Division, Department of Medicine, Universit\u00e0 degli Studi di Padova , Padova ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugo","family":"Corr\u00e0","sequence":"additional","affiliation":[{"name":"Cardiology Department, Istituti Clinici Scientifici Maugeri, IRCCS, Veruno Institute , Veruno ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Piepoli","sequence":"additional","affiliation":[{"name":"UOC Cardiologia, G da Saliceto Hospital , Piacenza ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Vignati","sequence":"additional","affiliation":[{"name":"U.O Scompenso, Centro Cardiologico Monzino, IRCCS , Milan ,","place":["Italy"]},{"name":"Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milano , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Salvioni","sequence":"additional","affiliation":[{"name":"U.O Scompenso, Centro Cardiologico Monzino, IRCCS , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Bonomi","sequence":"additional","affiliation":[{"name":"U.O Scompenso, Centro Cardiologico Monzino, IRCCS , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Mattavelli","sequence":"additional","affiliation":[{"name":"U.O Scompenso, Centro Cardiologico Monzino, IRCCS , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Arcari","sequence":"additional","affiliation":[{"name":"Cardiology Division, Santo Spirito Hospital , Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela B.","family":"Scardovi","sequence":"additional","affiliation":[{"name":"Cardiology Division, Santo Spirito Hospital , Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Perrone Filardi","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Federico II University of Naples , Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Lagioia","sequence":"additional","affiliation":[{"name":"Division of Cardiology, \"S. Maugeri\" Foundation, IRCCS, Institute of Cassano Murge , Bari ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Paolillo","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Federico II University of Naples , Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiano","family":"Magr\u00ec","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Azienda Ospedaliera Sant'Andrea, \u201cSapienza\u201d Universit\u00e0 degli Studi di Roma , Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Limongelli","sequence":"additional","affiliation":[{"name":"Cardiologia SUN, Ospedale Monaldi (Azienda dei Colli), Seconda Universit\u00e0 di Napoli , Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Metra","sequence":"additional","affiliation":[{"name":"Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia , Brescia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Senni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Failure and Heart Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII , Bergamo ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Scrutinio","sequence":"additional","affiliation":[{"name":"UOC Cardiologia, G da Saliceto Hospital , Piacenza ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Divisione di Cardiologia Riabilitativa, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Tradate ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[{"name":"UOC Cardiologia e Medicina cardiovascolare, Fondazione Gabriele Monasterio, CNR-Regione Toscana , Pisa ,","place":["Italy"]},{"name":"Life Science Institute, Life Science Institute, Scuola Superiore Sant'Anna , Pisa ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia , Brescia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaia","family":"Cattadori","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Cardiologia Riabilitativa, Multimedica IRCCS , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Parati","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca , Milan ,","place":["Italy"]},{"name":"Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Istituto Auxologico Italiano , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Re","sequence":"additional","affiliation":[{"name":"Cardiology Division, Cardiac Arrhythmia Center and Cardiomyopathies Unit, San Camillo-Forlanini Hospital , Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariantonietta","family":"Cicoira","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine, University of Verona , Verona ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Q.","family":"Villani","sequence":"additional","affiliation":[{"name":"UOC Cardiologia, G da Saliceto Hospital , Piacenza ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Min\u00e0","sequence":"additional","affiliation":[{"name":"Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS \u2013 ISMETT , Palermo ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Correale","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Foggia , Foggia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Frigerio","sequence":"additional","affiliation":[{"name":"Dipartimento Cardiologico \u2018A. 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