{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:13:48Z","timestamp":1791810828679,"version":"4.3.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Ministry of Health and Research National Program"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The MITRA-FR trial showed that among symptomatic patients with severe secondary mitral regurgitation, percutaneous repair did not reduce the risk of death or hospitalization for heart failure at 12\u2009months compared with guideline-directed medical treatment alone. We report the 24-month outcome from this trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>At 37 centres, we randomly assigned 304 symptomatic heart failure patients with severe secondary mitral regurgitation (effective regurgitant orifice area &amp;gt;20\u2009mm2 or regurgitant volume &amp;gt;30\u2009mL), and left ventricular ejection fraction between 15% and 40% to undergo percutaneous valve repair plus medical treatment (intervention group, n = 152) or medical treatment alone (control group, n = 152). The primary efficacy outcome was the composite of all-cause death and unplanned hospitalization for heart failure at 12\u2009months. At 24\u2009months, all-cause death and unplanned hospitalization for heart failure occurred in 63.8% of patients (97\/152) in the intervention group and 67.1% (102\/152) in the control group [hazard ratio (HR) 1.01, 95% confidence interval (CI) 0.77\u20131.34]. All-cause mortality occurred in 34.9% of patients (53\/152) in the intervention group and 34.2% (52\/152) in the control group (HR 1.02, 95% CI 0.70\u20131.50). Unplanned hospitalization for heart failure occurred in 55.9% of patients (85\/152) in the intervention group and 61.8% (94\/152) in the control group (HR 0.97, 95% CI 0.72\u20131.30).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with severe secondary mitral regurgitation, percutaneous repair added to medical treatment did not significantly reduce the risk of death or hospitalization for heart failure at 2\u2009years compared with medical treatment alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1616","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T12:10:20Z","timestamp":1567426220000},"page":"1619-1627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":196,"title":["Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation: Outcomes at 2\u2009Years"],"prefix":"10.1093","volume":"21","author":[{"given":"Bernard","family":"Iung","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris and INSERM 1148 , Paris ,","place":["France"]},{"name":"APHP, H\u00f4pital Bichat, DHU FIRE , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Armoiry","sequence":"additional","affiliation":[{"name":"Pharmacy Department and Laboratoire MATEIS, Hospices Civils de Lyon and Claude Bernard University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Vahanian","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Bichat, DHU FIRE , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Boutitie","sequence":"additional","affiliation":[{"name":"Lyon, France; Universit\u00e9 Lyon 1, Villeurbanne, France; CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, \u00c9quipe Biostatistique-Sant\u00e9, Service de Biostatistique - Bioinformatique, P\u00f4le Sant\u00e9 Publique, Hospices Civils de Lyon , Villeurbanne ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Mewton","sequence":"additional","affiliation":[{"name":"Hopital Cardiovasculaire Louis Pradel, Clinical Investigation Center & Heart Failure Department, INSERM 1407, Hospices Civils de Lyon and Claude Bernard University , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-No\u00ebl","family":"Trochu","sequence":"additional","affiliation":[{"name":"CHU Nantes, INSERM, Nantes Universit\u00e9, Clinique Cardiologique et des Maladies Vasculaires, CIC 1413, Institut du Thorax , Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lef\u00e8vre","sequence":"additional","affiliation":[{"name":"Institut Jacques Cartier , Massy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Messika-Zeitoun","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris and INSERM 1148 , Paris ,","place":["France"]},{"name":"Division of Cardiology, University of Ottawa Heart Institute , Ottawa ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Guerin","sequence":"additional","affiliation":[{"name":"CHU Nantes, INSERM, Nantes Universit\u00e9, Clinique Cardiologique et des Maladies Vasculaires, CIC 1413, Institut du Thorax , Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Cormier","sequence":"additional","affiliation":[{"name":"Institut Jacques 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