{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:24:04Z","timestamp":1794349444111,"version":"4.9.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Abbott Vascular International"},{"name":"Amgen Cardiovascular"},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bristol-Myers Squibb and Pfizer Alliance"},{"DOI":"10.13039\/501100022274","name":"Daiichi Sankyo Europe GmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Daiichi Sankyo Europe GmbH and Eli Lilly & Company Alliance"},{"DOI":"10.13039\/100006520","name":"Edwards","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003358","name":"Gedeon Richter","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003358","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Menarini International Operations"},{"name":"MSD-Merck & Co"},{"name":"Novartis Pharma AG"},{"DOI":"10.13039\/100017647","name":"ResMed","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Vifor"},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003358","name":"Gedeon Richter","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003358","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to assess age- and sex-related differences in management and 1-year risk for all-cause mortality and hospitalization in chronic heart failure (HF) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Of 16\u2009354 patients included in the European Society of Cardiology Heart Failure Long-Term Registry, 9428 chronic HF patients were analysed [median age: 66\u2009years; 28.5% women; mean left ventricular ejection fraction (LVEF) 37%]. Rates of use of guideline-directed medical therapy (GDMT) were high (angiotensin-converting enzyme inhibitors\/angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists: 85.7%, 88.7% and 58.8%, respectively). Crude GDMT utilization rates were lower in women than in men (all differences: P \u2264\u20090.001), and GDMT use became lower with ageing in both sexes, at baseline and at 1-year follow-up. Sex was not an independent predictor of GDMT prescription; however, age &amp;gt;75\u2009years was a significant predictor of GDMT underutilization. Rates of all-cause mortality were lower in women than in men (7.1% vs. 8.7%; P = 0.015), as were rates of all-cause hospitalization (21.9% vs. 27.3%; P &amp;lt; 0.001) and there were no differences in causes of death. All-cause mortality and all-cause hospitalization increased with greater age in both sexes. Sex was not an independent predictor of 1-year all-cause mortality (restricted to patients with LVEF \u226445%). Mortality risk was significantly lower in patients of younger age, compared to patients aged &amp;gt;75\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was a decline in GDMT use with advanced age in both sexes. Sex was not an independent predictor of GDMT or adverse outcomes. However, age &amp;gt;75\u2009years independently predicted lower GDMT use and higher all-cause mortality in patients with LVEF \u226445%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1645","type":"journal-article","created":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T02:01:05Z","timestamp":1576893665000},"page":"92-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":120,"title":["Sex- and Age-Related Differences in the Management and Outcomes of Chronic Heart Failure: An Analysis of Patients from the ESC HFA EORP Heart Failure Long-Term Registry"],"prefix":"10.1093","volume":"22","author":[{"given":"Mitja","family":"Lain\u0161\u010dak","sequence":"first","affiliation":[{"name":"Division of Cardiology, General Hospital Murska Sobota , Murska Sobota ,","place":["Slovenia"]},{"name":"Faculty of Medicine, University of Ljubljana , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Milinkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Centre of Serbia , Belgrade ,","place":["Serbia"]},{"name":"Faculty of Medicine, Belgrade University , Belgrade ,","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Polovina","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Centre of Serbia , Belgrade ,","place":["Serbia"]},{"name":"Faculty of Medicine, Belgrade University , Belgrade ,","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa G.","family":"Crespo-Leiro","sequence":"additional","affiliation":[{"name":"Unidad de Insuficiencia Cardiaca y Trasplante Cardiaco, Complexo Hospitalario Universitario A Coruna (CHUAC), INIBIC, UDC, CIBERCV , La Coruna ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars H.","family":"Lund","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division, Department of Medicine, Karolinska Institute, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Metabolism, Department of Cardiology, Berlin-Brandenburg Centre for Regenerative Therapies , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (Berlin partner site), Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology and Pneumology, University of Medicine G\u00f6ttingen , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Laroche","sequence":"additional","affiliation":[{"name":"EURObservational Research Programme, European Society of Cardiology , Sophia-Antipolis ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Universitario di Ferrara, University of Ferrara , Ferrara ,","place":["Italy"]},{"name":"GVM Care and Research, Maria Cecilia Hospital , Cotignola, RA ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.S.","family":"Coats","sequence":"additional","affiliation":[{"name":"Pharmacology Division, Centre of Clinical and Experimental Medicine, IRCCS San Raffaele Pisana , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"McDonagh","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine, King\u2019s College Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Failure Unit, Athens University Hospital Attikon , Athens ,","place":["Greece"]},{"name":"School of Medicine, National and Kapodistrian University of Athens , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo P.","family":"Maggioni","sequence":"additional","affiliation":[{"name":"EURObservational Research Programme, European Society of Cardiology , Sophia-Antipolis ,","place":["France"]},{"name":"ANMCO Research Centre , Florence ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo F.","family":"Piepoli","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Guglielmo da Saliceto Hospital , Piacenza ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe M.C.","family":"Rosano","sequence":"additional","affiliation":[{"name":"Cardiovascular and Cell Sciences Institute, King\u2019s College Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, University Hospital , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Simi\u0107","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Centre of Serbia , Belgrade ,","place":["Serbia"]},{"name":"Faculty of Medicine, Belgrade University , Belgrade ,","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milika","family":"A\u0161anin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Centre of Serbia , Belgrade ,","place":["Serbia"]},{"name":"Faculty of Medicine, Belgrade University , Belgrade ,","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Eicher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rhythmology and Heart Failure Unit, University Hospital Fran\u00e7ois Mitterrand , Dijon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet B.","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Cumhuriyet University , Sivas ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar M.","family":"Seferovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade University , Belgrade ,","place":["Serbia"]},{"name":"Serbian Academy of Sciences and Arts , Belgrade ,","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"2026011721331551100_ejhf1645-bib-0001","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"386","author":"Global Burden of Disease Study 2013 Collaborators","year":"2015","journal-title":"Lancet"},{"key":"2026011721331551100_ejhf1645-bib-0002","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart Disease and Stroke Statistics 2017 Update: a report from the American Heart Association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"2026011721331551100_ejhf1645-bib-0003","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/ejhf.890","article-title":"Clinical phenotypes and outcome of patients hospitalized for acute heart failure: the ESC Heart Failure Long-Term Registry","volume":"19","author":"Chioncel","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0004","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ehf2.12005","article-title":"Heart failure: preventing disease and death worldwide","volume":"1","author":"Ponikowski","year":"2014","journal-title":"ESC Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0005","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/ejhf.566","article-title":"European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions","volume":"18","author":"Crespo-Leiro","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0006","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/ejhf.813","article-title":"Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry","volume":"19","author":"Chioncel","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0007","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.amjcard.2008.04.009","article-title":"Gender differences in patients admitted with advanced decompensated heart failure","volume":"102","author":"Mullens","year":"2008","journal-title":"Am J Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0008","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.jacc.2003.05.012","article-title":"Gender differences in advanced heart failure: insights from the BEST study","volume":"42","author":"Ghali","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0009","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1253\/circj.CJ-13-1009","article-title":"Gender differences in clinical characteristics, treatment and long-term outcome in patients with stage C\/D heart failure in Japan. Report from the CHART-2 study","volume":"78","author":"Sakata","year":"2014","journal-title":"Circ J"},{"key":"2026011721331551100_ejhf1645-bib-0010","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ahj.2011.12.013","article-title":"Sex differences in in-hospital mortality in acute decompensated heart failure with reduced and preserved ejection fraction","volume":"163","author":"Hsich","year":"2012","journal-title":"Am Heart J"},{"key":"2026011721331551100_ejhf1645-bib-0011","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cardfail.2005.09.005","article-title":"Gender differences in in-hospital management and outcomes in patients with decompensated heart failure: analysis from the Acute Decompensated Heart Failure National Registry (ADHERE)","volume":"12","author":"Galvao","year":"2006","journal-title":"J Card Fail"},{"key":"2026011721331551100_ejhf1645-bib-0012","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00392-015-0810-y","article-title":"Gender differences in clinical characteristics and outcome of acute heart failure in sub-Saharan Africa: results of the THESUS-HF study","volume":"104","author":"Ogah","year":"2015","journal-title":"Clin Res Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0013","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijcard.2017.10.068","article-title":"Sex-related differences in chronic heart failure","volume":"255","author":"Aimo","year":"2018","journal-title":"Int J Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0014","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejim.2018.01.011","article-title":"Female gender and mortality risk in decompensated heart failure","volume":"51","author":"Scrutinio","year":"2018","journal-title":"Eur J Intern Med"},{"key":"2026011721331551100_ejhf1645-bib-0015","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejheart.2007.12.012","article-title":"Gender related differences in patients presenting with acute heart failure. Results from EuroHeart Failure Survey II","volume":"10","author":"Nieminen","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0016","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0167-5273(00)00298-9","article-title":"Does gender bias exist in the medical management of heart failure?","volume":"75","author":"Harjai","year":"2000","journal-title":"Int J Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0017","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1013706023974","article-title":"Management of heart failure in the elderly","volume":"7","author":"Rich","year":"2002","journal-title":"Heart Fail Rev"},{"key":"2026011721331551100_ejhf1645-bib-0018","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.amjcard.2009.02.057","article-title":"Age- and gender-related differences in quality of care and outcomes of patients hospitalized with heart failure (from OPTIMIZE-HF)","volume":"104","author":"Fonarow","year":"2009","journal-title":"Am J Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0019","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ejhf.510","article-title":"Physicians\u2019 adherence to guideline-recommended medications in heart failure with reduced ejection fraction: data from the QUALIFY global survey","volume":"18","author":"Komajda","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0020","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1097\/00005650-199807000-00010","article-title":"Gender differences in 1-year survival and quality of life among patients admitted with congestive heart failure","volume":"36","author":"Chin","year":"1998","journal-title":"Med Care"},{"key":"2026011721331551100_ejhf1645-bib-0021","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/eurheartj\/ehi251","article-title":"Adherence to guidelines is a predictor of outcome in chronic heart failure: the MAHLER survey","volume":"26","author":"Komajda","year":"2005","journal-title":"Eur Heart J"},{"key":"2026011721331551100_ejhf1645-bib-0022","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/eurjhf\/hft050","article-title":"EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot)","volume":"15","author":"Maggioni","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0023","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijcard.2009.07.014","article-title":"Gender differences among Norwegian patients with heart failure","volume":"146","author":"Brandsaeter","year":"2011","journal-title":"Int J Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002540","article-title":"Comorbidity health pathways in heart failure patients: a sequences-of-regressions analysis using cross-sectional data from 10\u2009575 patients in the Swedish Heart Failure Registry","volume":"15","author":"Lawson","year":"2018","journal-title":"PLoS Med"},{"key":"2026011721331551100_ejhf1645-bib-0025","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10557-015-6599-0","article-title":"Heart failure in women. Insights from the Framingham Heart Study","volume":"29","author":"Kenchaiah","year":"2015","journal-title":"Cardiovasc Drugs Ther"},{"key":"2026011721331551100_ejhf1645-bib-0026","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.rce.2015.02.010","article-title":"Gender related differences in clinical profile and outcome of patients with heart failure. Results of the RICA Registry","volume":"215","author":"Conde-Martel","year":"2015","journal-title":"Rev Clin Esp"},{"key":"2026011721331551100_ejhf1645-bib-0027","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1161\/CIRCULATIONAHA.106.673442","article-title":"Sex differences in clinical characteristics and prognosis in a broad spectrum of patients with heart failure: results of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program","volume":"115","author":"O\u2019Meara","year":"2007","journal-title":"Circulation"},{"key":"2026011721331551100_ejhf1645-bib-0028","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/eurjhf\/hfs026","article-title":"Gender and survival in patients with heart failure: interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis","volume":"14","author":"Martinez-Selles","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0029","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/clc.22917","article-title":"Sex differences in heart failure","volume":"41","author":"Eisenberg","year":"2018","journal-title":"Clin Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0030","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ahj.2014.12.004","article-title":"Female sex is associated with a lower risk of stroke in patients with heart failure","volume":"169","author":"Melgaard","year":"2015","journal-title":"Am Heart J"},{"key":"2026011721331551100_ejhf1645-bib-0031","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jacc.2005.01.072","article-title":"Insights from the NHLBI-Sponsored Women\u2019s Ischemia Syndrome Evaluation (WISE) Study: Part I: gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies","volume":"47","author":"Shaw","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0032","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.amjmed.2014.08.024","article-title":"Multimorbidity in heart failure: a community perspective","volume":"128","author":"Chamberlain","year":"2015","journal-title":"Am J Med"},{"key":"2026011721331551100_ejhf1645-bib-0033","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40248-015-0023-2","article-title":"Prevalence of different comorbidities in COPD patients by gender and GOLD stage","volume":"10","author":"Dal Negro","year":"2015","journal-title":"Multidiscip Respir Med"},{"key":"2026011721331551100_ejhf1645-bib-0034","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.trsl.2013.04.003","article-title":"COPD and gender differences: an update","volume":"162","author":"Aryal","year":"2013","journal-title":"Transl Res"},{"key":"2026011721331551100_ejhf1645-bib-0035","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.trsl.2013.05.001","article-title":"Chronic obstructive pulmonary disease and cardiovascular disease","volume":"162","author":"Bhatt","year":"2013","journal-title":"Transl Res"},{"key":"2026011721331551100_ejhf1645-bib-0036","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jchf.2015.09.014","article-title":"Prevalence and predictors of sleep-disordered breathing in patients with stable chronic heart failure: the SchlaHF Registry","volume":"4","author":"Arzt","year":"2016","journal-title":"JACC Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0037","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1164\/ajrccm.160.4.9903020","article-title":"Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure","volume":"160","author":"Sin","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026011721331551100_ejhf1645-bib-0038","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2006.06.055","article-title":"Depression in heart failure: a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes","volume":"48","author":"Rutledge","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0039","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/eurjhf\/hft115","article-title":"Sex-specific acute heart failure phenotypes and outcomes from PROTECT","volume":"15","author":"Meyer","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10880-010-9217-0","article-title":"Utility of the Millon Behavioral Medicine Diagnostic to predict medication adherence in patients diagnosed with heart failure","volume":"18","author":"Farrell","year":"2011","journal-title":"J Clin Psychol Med Settings"},{"key":"2026011721331551100_ejhf1645-bib-0041","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.ejheart.2007.06.011","article-title":"Depression and survival in chronic heart failure: does gender play a role?","volume":"9","author":"Faller","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0042","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCHEARTFAILURE.112.972828","article-title":"Predictors of new-onset heart failure: differences in preserved versus reduced ejection fraction","volume":"6","author":"Ho","year":"2013","journal-title":"Circ Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0043","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/eurheartj\/ehs070","article-title":"Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community","volume":"33","author":"Ho","year":"2012","journal-title":"Eur Heart J"},{"key":"2026011721331551100_ejhf1645-bib-0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.ahj.2008.12.016","article-title":"Influence of patient age and sex on delivery of guideline-recommended heart failure care in the outpatient cardiology practice setting: findings from IMPROVE HF","volume":"157","author":"Yancy","year":"2009","journal-title":"Am Heart J"},{"key":"2026011721331551100_ejhf1645-bib-0045","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/ejhf.1182","article-title":"Factors associated with underuse of mineralocorticoid receptor antagonists in heart failure with reduced ejection fraction: an analysis of 11 215 patients from the Swedish Heart Failure Registry","volume":"20","author":"Savarese","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0046","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/ejhf.1199","article-title":"Incidence, predictors and clinical management of hyperkalaemia in new users of mineralocorticoid receptor antagonists","volume":"20","author":"Trevisan","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0047","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/ejhf.1079","article-title":"Potassium and the use of renin\u2013angiotensin\u2013aldosterone system inhibitors in heart failure with reduced ejection fraction: data from BIOSTAT-CHF","volume":"20","author":"Beusekamp","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0048","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1016\/j.jacc.2019.03.467","article-title":"Deprescribing in older adults with cardiovascular disease","volume":"73","author":"Krishnaswami","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0049","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1002\/ejhf.1308","article-title":"The frailty syndrome and outcomes in the TOPCAT trial","volume":"20","author":"Sanders","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0050","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/ejhf.1216","article-title":"Sex- and age-based differences in the natural history and outcome of dilated cardiomyopathy","volume":"20","author":"Halliday","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0051","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/ejhf.600","article-title":"Reframing the association and significance of co-morbidities in heart failure","volume":"18","author":"Triposkiadis","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2026011721331551100_ejhf1645-bib-0052","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.amjcard.2009.12.016","article-title":"Influence of renal function on the use of guideline-recommended therapies for patients with heart failure","volume":"105","author":"Heywood","year":"2010","journal-title":"Am J Cardiol"},{"key":"2026011721331551100_ejhf1645-bib-0053","doi-asserted-by":"crossref","DOI":"10.1002\/ejhf.1459","article-title":"Physicians\u2019 guideline adherence is associated with long-term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry","author":"Komajda","year":"2019","journal-title":"Eur J Heart Fail"}],"updated-by":[{"DOI":"10.1002\/ejhf.1947","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000}}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejhf.1645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.1645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.1645","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/22\/1\/92\/66112934\/eurjhf_22_1_92.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/22\/1\/92\/66112934\/eurjhf_22_1_92.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:34:00Z","timestamp":1768703640000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/22\/1\/92\/8385129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12,20]]},"published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ejhf.1645","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2019,12,20]]},"assertion":[{"value":"2019-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}