{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:00:17Z","timestamp":1768932017111,"version":"3.49.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Left ventricular assist devices (LVADs) are increasingly being used as life-saving therapy for end-stage advanced heart failure. Diabetes is prevalent in advanced heart failure patients. In this study, we sought to investigate the effects of mechanical circulatory support on diabetic parameters with LVAD implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this retrospective study, data on 244 LVAD recipients between 2006 and 2013 were reviewed. Patients without history of diabetes, death within the first 3 months after LVAD implantation, heart transplantation after LVAD, or LVAD explantation were excluded from the study. Baseline demographic, laboratory, and echocardiographic information prior to LVAD placement and 6-month follow-up were obtained. Laboratory values indicative of diabetic control were found to improve significantly at 6 months post-LVAD implantation (glycated haemoglobin, 7.2 vs. 6.1%, P\u2009&amp;lt;\u20090.0001; serum fasting glucose, 141 vs. 122\u2009mg\/dL, P\u2009=\u20090.003; mean daily insulin dose, 30 vs. 24 IU\/day, P\u2009=\u20090.02). Additionally, the use of oral hypoglycaemic medication was successfully discontinued in six patients at 6 months post-LVAD implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long-term LVAD therapy is associated with improvement in diabetic control which is probabvly due to improvements in cardiac output and normalization of biochemical derangements resulting from diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.166","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T02:55:10Z","timestamp":1412823310000},"page":"1120-1124","source":"Crossref","is-referenced-by-count":14,"title":["Mechanical Circulatory Support Improves Diabetic Control in Patients with Advanced Heart Failure"],"prefix":"10.1093","volume":"16","author":[{"given":"Burhan","family":"Mohamedali","sequence":"first","affiliation":[{"name":"Division of Cardiology and Cardiothoracic Surgery, University of Illinois Hospitals and Health Sciences System , Chicago, IL ,","place":["USA"]},{"name":"Advocate Christ Medical Center , Oak Lawn, IL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gardner","family":"Yost","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Cardiothoracic Surgery, University of Illinois Hospitals and Health Sciences System , Chicago, IL ,","place":["USA"]},{"name":"Advocate Christ Medical Center , Oak Lawn, IL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetha","family":"Bhat","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Cardiothoracic Surgery, University of Illinois Hospitals and Health Sciences System , Chicago, IL ,","place":["USA"]},{"name":"Advocate Christ Medical Center , Oak Lawn, IL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,10,9]]},"reference":[{"key":"2026011921125557700_ejhf166-bib-0001","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1172\/JCI10762","article-title":"Insulin resistance and cardiovascular disease","volume":"106","author":"Ginsberg","year":"2000","journal-title":"J Clin Invest"},{"key":"2026011921125557700_ejhf166-bib-0002","doi-asserted-by":"crossref","first-page":"13A","DOI":"10.1016\/j.amjcard.2003.11.003","article-title":"Diabetic cardiomyopathy: a metabolic perspective","volume":"93","author":"Avogaro","year":"2004","journal-title":"Am J Cardiol"},{"key":"2026011921125557700_ejhf166-bib-0003","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/cvr\/cvr052","article-title":"Metabolic remodelling in human heart failure","volume":"90","author":"Tuunanen","year":"2011","journal-title":"Cardiovasc Res"},{"key":"2026011921125557700_ejhf166-bib-0004","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s00125-014-3259-z","article-title":"Association of heart failure severity with risk of diabetes: a Danish nationwide cohort study","volume":"57","author":"Demant","year":"2014","journal-title":"Diabetologia"},{"key":"2026011921125557700_ejhf166-bib-0005","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.jtcvs.2003.07.035","article-title":"Bridging to transplant with the HeartMate left ventricular assist device: the Columbia Presbyterian 12-year experience","volume":"127","author":"Morgan","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026011921125557700_ejhf166-bib-0006","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1161\/01.CIR.97.20.2079","article-title":"Mechanical circulatory support and cardiac transplantation","volume":"97","author":"Hunt","year":"1998","journal-title":"Circulation"},{"key":"2026011921125557700_ejhf166-bib-0007","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/eurjhf\/hfr050","article-title":"The effect of ventricular assist devices on long-term post-transplant outcomes: a systematic review of observational studies","volume":"13","author":"Alba","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"2026011921125557700_ejhf166-bib-0008","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/MAT.0000000000000064","article-title":"Improvement in blood glucose control in patients with diabetes after implantation of left ventricular assist devices","volume":"60","author":"Guglin","year":"2014","journal-title":"ASAIO J"},{"key":"2026011921125557700_ejhf166-bib-0009","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/01.CIR.0000105701.98663.D4","article-title":"Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice","volume":"109","author":"Yang","year":"2004","journal-title":"Circulation"},{"key":"2026011921125557700_ejhf166-bib-0010","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1161\/01.CIR.97.14.1382","article-title":"Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats","volume":"97","author":"Bozkurt","year":"1998","journal-title":"Circulation"},{"key":"2026011921125557700_ejhf166-bib-0011","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1161\/01.CIR.0000096481.45105.13","article-title":"Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradation","volume":"108","author":"Razeghi","year":"2003","journal-title":"Circulation"},{"key":"2026011921125557700_ejhf166-bib-0012","first-page":"213","article-title":"Congestive heart failure predicts the development of non-insulin-dependent diabetes mellitus in the elderly. The Osservatorio Geriatrico Regione Campania Group","volume":"23","author":"Amato","year":"1997","journal-title":"Diabetes Metab"},{"key":"2026011921125557700_ejhf166-bib-0013","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1093\/eurjhf\/hfq160","article-title":"Heart failure severity, as determined by loop diuretic dosages, predicts the risk of developing diabetes after myocardial infarction: a nationwide cohort study","volume":"12","author":"Andersson","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2026011921125557700_ejhf166-bib-0014","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/eurjhf\/hfq204","article-title":"Improved diabetic control in advanced heart failure patients treated with left ventricular assist devices","volume":"13","author":"Uriel","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"2026011921125557700_ejhf166-bib-0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11897-009-0014-8","article-title":"Insulin resistance and heart failure","volume":"6","author":"Heck","year":"2009","journal-title":"Curr Heart Fail Rep"},{"key":"2026011921125557700_ejhf166-bib-0016","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jamda.2012.11.010","article-title":"Improving diabetes care and patient outcomes in skilled-care communities: successes and lessons from a quality improvement initiative","volume":"14","author":"Boyle","year":"2013","journal-title":"J Am Med Dir Assoc"},{"key":"2026011921125557700_ejhf166-bib-0017","doi-asserted-by":"crossref","first-page":"E98","DOI":"10.1532\/HSF98.2013323","article-title":"Neurohormonal regulation and improvement in blood glucose control: reduction of insulin requirement in patients with a nonpulsatile ventricular assist device","volume":"17","author":"Koerner","year":"2014","journal-title":"Heart Surg Forum"},{"issue":"9 Suppl","key":"2026011921125557700_ejhf166-bib-0018","doi-asserted-by":"crossref","first-page":"II191","DOI":"10.1161\/01.CIR.92.9.191","article-title":"Effect of the implantable left ventricular assist device on neuroendocrine activation in heart failure","volume":"92","author":"James","year":"1995","journal-title":"Circulation"},{"key":"2026011921125557700_ejhf166-bib-0019","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/01.CIR.100.11.1189","article-title":"Decreased expression of tumor necrosis factor-alpha in failing human myocardium after mechanical circulatory support: a potential mechanism for cardiac recovery","volume":"100","author":"Torre-Amione","year":"1999","journal-title":"Circulation"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejhf.166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/16\/10\/1120\/66433428\/eurjhf_16_10_1120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/16\/10\/1120\/66433428\/eurjhf_16_10_1120.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:14:58Z","timestamp":1768875298000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/16\/10\/1120\/8427633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,1]]},"references-count":19,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,9]]},"published-print":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ejhf.166","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,10]]},"published":{"date-parts":[[2014,10,1]]}}}