{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:55:12Z","timestamp":1788951312615,"version":"build-2803163510"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":2187,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/05\/087"],"award-info":[{"award-number":["PG\/05\/087"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/05\/087"],"award-info":[{"award-number":["PG\/05\/087"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Treatment options for patients with non-obstructive hypertrophic cardiomyopathy (HCM) are limited. We sought to determine whether biventricular (BiV) pacing improves exercise capacity in HCM patients, and whether this is via augmented diastolic filling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Thirty-one patients with symptomatic non-obstructive HCM were enrolled. Following device implantation, patients underwent detailed assessment of exercise diastolic filling using radionuclide ventriculography in BiV and sham pacing modes. Patients then entered an 8-month crossover study of BiV and sham pacing in random order, to assess the effect on exercise capacity [peak oxygen consumption (VO2)]. Patients were grouped on pre-specified analysis according to whether left ventricular end-diastolic volume increased (+LVEDV) or was unchanged\/decreased (\u2013LVEDV) with exercise at baseline. Twenty-nine patients (20 male, mean age 55\u2009years) completed the study. There were 14\u2009+LVEDV patients and 15 \u2013LVEDV patients. Baseline peak VO2 was lower in \u2013LVEDV patients vs. +LVEDV patients (16.2\u2009\u00b1\u20090.9 vs. 19.9\u2009\u00b1\u20091.1 mL\/kg\/min, P = 0.04). BiV pacing significantly increased exercise \u0394LVEDV (P = 0.004) and \u0394stroke volume (P = 0.008) in \u2013LVEDV patients, but not in +LVEDV patients. Left ventricular ejection fraction and end-systolic elastance did not increase with BiV pacing in either group. This translated into significantly greater improvements in exercise capacity (peak VO2\u2009+\u20091.4 mL\/kg\/min, P = 0.03) and quality of life scores (P = 0.02) in \u2013LVEDV patients during the crossover study. There was no effect on left ventricular mechanical dyssynchrony in either group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Symptomatic patients with non-obstructive HCM may benefit from BiV pacing via augmentation of diastolic filling on exercise rather than contractile improvement. This may be due to relief of diastolic ventricular interaction.<\/jats:p>\n                    <jats:p>Clinical Trial Registration: ClinicalTrials.gov \u00a0NCT00504647.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1722","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T20:59:37Z","timestamp":1579813177000},"page":"1263-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biventricular Pacemaker Therapy Improves Exercise Capacity in Patients with Non-Obstructive Hypertrophic Cardiomyopathy Via Augmented Diastolic Filling on Exercise"],"prefix":"10.1093","volume":"22","author":[{"given":"Ibrar","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Birmingham , Birmingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brodie L.","family":"Loudon","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Abozguia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Birmingham , Birmingham ,","place":["UK"]},{"name":"Lancashire Cardiac Centre, Blackpool Victoria Hospital , Blackpool ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donnie","family":"Cameron","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh N.","family":"Shivu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Birmingham , Birmingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh T.","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Birmingham , Birmingham ,","place":["UK"]},{"name":"Cardiology Department, Royal Stoke University Hospital UHNM NHS Trust , Newcastle ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Maher","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Birmingham , Birmingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Stegemann","sequence":"additional","affiliation":[{"name":"Bakken Research Centre, Medtronic Inc. , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Royal Berkshire NHS Foundation Trust , Reading ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Marshall","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Birmingham, Welcome Trust Clinical Research Facility , Birmingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nightingale","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Birmingham, Welcome Trust Clinical Research Facility , Birmingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Leyva","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Queen Elizabeth Hospital , Birmingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios S.","family":"Vassiliou","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"McKenna","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College of London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry","family":"Elliott","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College of London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Frenneaux","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"2026011721360694900_ejhf1722-bib-0001","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults. 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